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Found 21 with Last Name = 'lyko' and Initial = 'f'
TargetDNA (cytosine-5)-methyltransferase 3B(Homo sapiens (Human))
Deutsches Krebsforschungszentrum

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human recombinant DNMT3B expressed in baculovirus-insect cell system by scintillation countingMore data for this Ligand-Target Pair
TargetOrphan methyltransferase M.SssI(Spiroplasma monobiae strain MQ-1)
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50180789(1,2-bis(7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-y...)
Affinity DataIC50:  400nMAssay Description:Inhibition of recombinant CpG methylase M.SssIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrphan methyltransferase M.SssI(Spiroplasma monobiae strain MQ-1)
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50180790(2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)prop...)
Affinity DataIC50:  600nMAssay Description:Inhibition of recombinant CpG methylase M.SssIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Deutsches Krebsforschungszentrum

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation countingMore data for this Ligand-Target Pair
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50597526(CHEMBL5187166)
Affinity DataIC50:  1.29E+4nMAssay Description:Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS by isothermal titration calorimetry ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50378739(SINEFUNGIN | jm2c00120, Sinefungin)
Affinity DataIC50:  1.32E+4nMAssay Description:Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS by isothermal titration calorimetry ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  1.58E+4nMAssay Description:Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS by isothermal titration calorimetry ass...More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 3B(Homo sapiens (Human))
Deutsches Krebsforschungszentrum

Curated by ChEMBL
LigandPNGBDBM11979(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human recombinant DNMT3B expressed in baculovirus-insect cell system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50597525(CHEMBL5202371)
Affinity DataIC50:  3.22E+4nMAssay Description:Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS by isothermal titration calorimetry ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50597524(CHEMBL5173553)
Affinity DataIC50:  3.97E+4nMAssay Description:Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS by isothermal titration calorimetry ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Deutsches Krebsforschungszentrum

Curated by ChEMBL
LigandPNGBDBM50180790(2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)prop...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibitory activity against DNA methyl transferase in leukemic NALM6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50597523(CHEMBL1091913)
Affinity DataIC50:  7.71E+4nMAssay Description:Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS by isothermal titration calorimetry ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Deutsches Krebsforschungszentrum

Curated by ChEMBL
LigandPNGBDBM11979(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Affinity DataIC50:  9.20E+4nMAssay Description:Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Deutsches Krebsforschungszentrum

Curated by ChEMBL
LigandPNGBDBM50180789(1,2-bis(7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-y...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory activity against DNA methyl transferase in leukemic NALM6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Deutsches Krebsforschungszentrum

Curated by ChEMBL
LigandPNGBDBM50308983(2-(4-bromo-2-(4-(carboxymethoxy)benzoyl)phenoxy)ac...)
Affinity DataIC50:  2.12E+5nMAssay Description:Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50597525(CHEMBL5202371)
Affinity DataKd:  1.05E+4nMAssay Description:Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as dissociation constant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50597524(CHEMBL5173553)
Affinity DataKd:  1.04E+4nMAssay Description:Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as dissociation constant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50597523(CHEMBL1091913)
Affinity DataKd:  1.14E+4nMAssay Description:Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as dissociation constant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50378739(SINEFUNGIN | jm2c00120, Sinefungin)
Affinity DataKd:  7.50E+3nMAssay Description:Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as dissociation constant...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataKd:  1.36E+4nMAssay Description:Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as dissociation constant...More data for this Ligand-Target Pair
TargettRNA (cytosine(38)-C(5))-methyltransferase(Homo sapiens)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50597526(CHEMBL5187166)
Affinity DataKd:  8.10E+3nMAssay Description:Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as dissociation constant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed