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Target
tRNA (cytosine(38)-C(5))-methyltransferase
Ligand
BDBM50597525
Substrate
n/a
Meas. Tech.
ChEMBL_2223596 (CHEMBL5136930)
IC50
32200±n/a nM
Citation
 Schwickert, M; Fischer, TR; Zimmermann, RA; Hoba, SN; Meidner, JL; Weber, M; Weber, M; Stark, MM; Koch, J; Jung, N; Kersten, C; Windbergs, M; Lyko, F; Helm, M; Schirmeister, T Discovery of Inhibitors of DNA Methyltransferase 2, an Epitranscriptomic Modulator and Potential Target for Cancer Treatment. J Med Chem 65:9750-9788 (2022) [PubMed] 
Target
Name:
tRNA (cytosine(38)-C(5))-methyltransferase
Synonyms:
2.1.1.204 | DNA (cytosine-5)-methyltransferase-like protein 2 | DNA MTase homolog HsaIIP | DNA methyltransferase homolog HsaIIP | DNMT2 | M.HsaIIP | PuMet | TRDMT1 | TRDMT_HUMAN
Type:
PROTEIN
Mol. Mass.:
44593.53
Organism:
Homo sapiens
Description:
ChEMBL_118874
Residue:
391
Sequence:
MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE
  
Inhibitor
Name:
BDBM50597525
Synonyms:
CHEMBL5202371
Type:
Small organic molecule
Emp. Form.:
C19H27N7O5
Mol. Mass.:
433.4616
SMILES:
CCC#CCN(CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|
Structure:
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