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Found 490 with Last Name = 'mackerell' and Initial = 'a'
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50000787((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydr...)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50000787((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydr...)
Affinity DataKi:  1.07nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in rat brain homogenate after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50000787((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydr...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in rat brain homogenate after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158355(CHEMBL3781822 | US10858316, Compound 3bl)
Affinity DataKi:  31nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158354(CHEMBL3780397)
Affinity DataKi:  33nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589742(CHEMBL5173872)
Affinity DataKi:  39nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: <40nMAssay Description:Inhibition of BCL-xL (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: <40nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158326(CHEMBL3781669 | US10858316, Compound 3bg)
Affinity DataKi:  79nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158353(CHEMBL3780803 | US10858316, Compound 3bj)
Affinity DataKi:  80nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158322(CHEMBL3780225 | US10858316, Compound 3bd)
Affinity DataKi:  82nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158324(CHEMBL3780311 | US10858316, Compound 3be)
Affinity DataKi:  114nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158333(CHEMBL3780473 | US10858316, Compound 3bi)
Affinity DataKi:  117nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158332(CHEMBL3780719 | US10858316, Compound 3bh)
Affinity DataKi:  173nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50424732(CHEMBL2314209)
Affinity DataKi:  247nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetIleal sodium/bile acid cotransporter(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50322476((2S)-5-(4-tert-butylphenylamino)-2-((4R)-4-((3R,7R...)
Affinity DataKi:  275nMAssay Description:Inhibition of human ASBT expressed in MDCK cells assessed as inhibition of [3H]taurocholic acid uptake after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158325(CHEMBL3781894 | US10858316, Compound 3bf)
Affinity DataKi:  284nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158186(CHEMBL3781396 | US10858316, Compound 3bc)
Affinity DataKi:  335nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589726(CHEMBL5206019)
Affinity DataKi:  420nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158168(CHEMBL3780113 | US10858316, Compound 3o)
Affinity DataKi:  420nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589731(CHEMBL5182327 | US11760752, Compound 38)
Affinity DataKi:  460nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589739(CHEMBL5197460)
Affinity DataKi:  460nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158184(CHEMBL3780576 | US10858316, Compound 3ba)
Affinity DataKi:  487nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589724(CHEMBL5188517 | US11760752, Compound 31)
Affinity DataKi:  510nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589725(CHEMBL5209122)
Affinity DataKi:  530nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158356(CHEMBL3781019 | US10858316, Compound 3ca)
Affinity DataKi:  566nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589727(CHEMBL5172723)
Affinity DataKi:  570nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIleal sodium/bile acid cotransporter(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50322507((2S)-5-(3-tert-butylphenylamino)-2-((4R)-4-((3R,7R...)
Affinity DataKi:  587nMAssay Description:Inhibition of human ASBT expressed in MDCK cells assessed as inhibition of [3H]taurocholic acid uptake after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589729(CHEMBL5176177)
Affinity DataKi:  600nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589728(CHEMBL5181405)
Affinity DataKi:  620nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589733(CHEMBL5183183 | US11760752, Compound 40)
Affinity DataKi:  660nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589740(CHEMBL5192657)
Affinity DataKi:  710nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589737(CHEMBL5192774)
Affinity DataKi:  710nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589741(CHEMBL5182219)
Affinity DataKi:  770nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589736(CHEMBL5209295)
Affinity DataKi:  840nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIleal sodium/bile acid cotransporter(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50322501((2S)-2-((4R)-4-((3R,7R,8R,9S,10S,13R,14S,17R)-3,7-...)
Affinity DataKi:  889nMAssay Description:Inhibition of human ASBT expressed in MDCK cells assessed as inhibition of [3H]taurocholic acid uptake after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589734(CHEMBL5203579)
Affinity DataKi:  900nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589735(CHEMBL5191785)
Affinity DataKi:  960nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589738(CHEMBL5180236)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589730(CHEMBL5178609)
Affinity DataKi:  1.12E+3nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIleal sodium/bile acid cotransporter(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50322480((2S)-2-((4R)-4-((3R,7R,8R,9S,10S,13R,14S,17R)-3,7-...)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of human ASBT expressed in MDCK cells assessed as inhibition of [3H]taurocholic acid uptake after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158185(CHEMBL3781946 | US10858316, Compound 3bb)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589730(CHEMBL5178609)
Affinity DataKi:  1.18E+3nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589724(CHEMBL5188517 | US11760752, Compound 31)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50424732(CHEMBL2314209)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589738(CHEMBL5180236)
Affinity DataKi:  1.22E+3nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIleal sodium/bile acid cotransporter(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50322498((2S)-2-((4R)-4-((3R,7R,8R,9S,10S,13R,14S,17R)-3,7-...)
Affinity DataKi:  1.25E+3nMAssay Description:Inhibition of human ASBT expressed in MDCK cells assessed as inhibition of [3H]taurocholic acid uptake after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589728(CHEMBL5181405)
Affinity DataKi:  1.28E+3nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589727(CHEMBL5172723)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589725(CHEMBL5209122)
Affinity DataKi:  1.32E+3nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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