Affinity DataKi: 9.00E+3nMAssay Description:Inhibition of N-terminal His-tagged Zika virus NS2B (46 to 99 residues) - NS3 (1 to 187 residues) protease domain expressed in Rosetta2-(DE3) assesse...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
National Hellenic Research Foundation
Curated by ChEMBL
National Hellenic Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal His6-tagged Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
National Hellenic Research Foundation
Curated by ChEMBL
National Hellenic Research Foundation
Curated by ChEMBL
Affinity DataIC50: 199nMAssay Description:Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
National Hellenic Research Foundation
Curated by ChEMBL
National Hellenic Research Foundation
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of N-terminal His-tagged Zika virus NS2B (49 to 95 residues) - NS3 (1 to 185 residues) protease domain expressed in Escherichia coli Bl21(...More data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 820nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 990nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of DENV2 NS2B-NS3 protease expressed in Escherichia coli Rosetta2(DE3) using Abz-RRRRSAG-nTyr as substrate preincubated with enzyme for 30...More data for this Ligand-Target Pair
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
National Hellenic Research Foundation
Curated by ChEMBL
National Hellenic Research Foundation
Curated by ChEMBL
Affinity DataIC50: 2.09E+3nMAssay Description:Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
National Hellenic Research Foundation
Curated by ChEMBL
National Hellenic Research Foundation
Curated by ChEMBL
Affinity DataIC50: 2.19E+3nMAssay Description:Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
National Hellenic Research Foundation
Curated by ChEMBL
National Hellenic Research Foundation
Curated by ChEMBL
Affinity DataIC50: 2.57E+3nMAssay Description:Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.71E+3nMAssay Description:Inhibition of DENV2 NS2B-NS3 proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of DENV2 NS2B-NS3 proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of DENV2 NS2B-NS3 proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 3.65E+3nMAssay Description:Inhibition of N-terminal linked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE3)...More data for this Ligand-Target Pair
Affinity DataIC50: 4.04E+3nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of N-terminal His6-tagged Zika virus NS2B (46 to 99 residues) - NS3 (1 to 187 residues) protease domain expressed in Rosetta2-(DE3) using ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of DENV2 NS2B-NS3 proteaseMore data for this Ligand-Target Pair
TargetNuclear factor of activated T-cells, cytoplasmic 1(Homo sapiens)
Universitat Aut£Noma De Barcelona
Curated by ChEMBL
Universitat Aut£Noma De Barcelona
Curated by ChEMBL
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of NFATC activity in HEK293T cells preincubated for 2 hrs followed by ionomycin/phorbol 12-myristate 13-acetate stimulation and measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of DENV2 NS2B-NS3 proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of DENV2 NS2B-NS3 proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 9.19E+3nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of DENV2 NS2B-NS3 proteaseMore data for this Ligand-Target Pair
TargetNuclear factor of activated T-cells, cytoplasmic 1(Homo sapiens)
Universitat Aut£Noma De Barcelona
Curated by ChEMBL
Universitat Aut£Noma De Barcelona
Curated by ChEMBL
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of NFATC activity in HEK293T cells preincubated for 2 hrs followed by ionomycin/phorbol 12-myristate 13-acetate stimulation and measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of N-terminal His6-tagged Zika virus NS2B (49 to 95 residues) - NS3 (1 to 170 residues) protease domain expressed in Escherichia coli Bl21...More data for this Ligand-Target Pair
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 1.49E+4nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2 EDEN2 infected in human Huh-7 cellsMore data for this Ligand-Target Pair
TargetNuclear factor of activated T-cells, cytoplasmic 1(Homo sapiens)
Universitat Aut£Noma De Barcelona
Curated by ChEMBL
Universitat Aut£Noma De Barcelona
Curated by ChEMBL
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of NFATC activity in HEK293T cells preincubated for 2 hrs followed by ionomycin/phorbol 12-myristate 13-acetate stimulation and measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 2.56E+4nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 3.25E+4nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 3.83E+4nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
Affinity DataIC50: 4.76E+4nMAssay Description:Inhibition of N-terminal linked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE3)...More data for this Ligand-Target Pair
Affinity DataIC50: 4.95E+4nMAssay Description:Inhibition of N-terminal linked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE3)...More data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+5nMAssay Description:Inhibition of N-terminal linked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE3)...More data for this Ligand-Target Pair
Affinity DataIC50: 1.21E+5nMAssay Description:Inhibition of DENV2 NS2B-NS3 proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4.32E+5nMAssay Description:Inhibition of DENV2 NS2B-NS3 protease assessed as inhibition of protease intermolecular processingMore data for this Ligand-Target Pair
Affinity DataEC50: 4.20E+3nMAssay Description:Inhibition of NS2B-NS3 intramolecular cleavage in Dengue virus 2 infected in LLC-MK2 cells assessed as inhibition of viral replication measured afer ...More data for this Ligand-Target Pair