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Found 353 with Last Name = 'mccowan' and Initial = 'jr'
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075926(3-(3-Methoxy-4-pyrrolidin-1-ylmethyl-benzyl)-2-[4-...)
Affinity DataKi:  0.300nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075934(2-[4-(2-Amino-3-hydroxy-propoxy)-phenyl]-3-(3-meth...)
Affinity DataKi:  0.400nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075928(3-(3-Methoxy-4-pyrrolidin-1-ylmethyl-benzyl)-2-[6-...)
Affinity DataKi:  0.5nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075937(2-{4-[2-(2-Hydroxymethyl-pyrrolidin-1-yl)-ethoxy]-...)
Affinity DataKi:  0.5nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075938(3-(3-Methoxy-4-pyrrolidin-1-ylmethyl-benzyl)-2-[4-...)
Affinity DataKi:  0.900nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075932(2-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-N-{4-[...)
Affinity DataKi:  0.900nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075935(3-(3-Methyl-4-pyrrolidin-1-ylmethyl-benzyl)-2-[4-(...)
Affinity DataKi:  1.90nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075931(3-(3-BROMO-4-PYRROLIDIN-1-YLMETHYL-BENZYL)-2-[4-PY...)
Affinity DataKi:  2.10nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075939(2-Dimethylamino-N-{4-[6-hydroxy-3-(3-methoxy-4-pyr...)
Affinity DataKi:  2.30nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075927(2-[4-(2-Amino-ethoxy)-phenyl]-3-(3-methoxy-4-pyrro...)
Affinity DataKi:  3.80nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075930(2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-3-(4-pyrro...)
Affinity DataKi:  4.10nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075933(2-[4-(2-Amino-ethyl)-phenyl]-3-(3-methoxy-4-pyrrol...)
Affinity DataKi:  5.10nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075941(3-(3-Hydroxy-4-pyrrolidin-1-ylmethyl-benzyl)-2-[4-...)
Affinity DataKi:  5.10nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228863((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataKi:  5.5nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075929(2-Amino-N-{4-[6-hydroxy-3-(3-methoxy-4-pyrrolidin-...)
Affinity DataKi:  7nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075940(5-{6-Hydroxy-2-[4-(2-pyrrolidin-1-yl-ethoxy)-pheny...)
Affinity DataKi:  7.20nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075936(3-(3-Aminomethyl-4-pyrrolidin-1-ylmethyl-benzyl)-2...)
Affinity DataKi:  11nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132988(4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061849((S)-2-Benzenesulfonylamino-3-{3-[(5-carbamimidoyl-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061840((S)-3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50082933(CHEMBL323720 | [6-(4-Carbamimidoyl-benzoylamino)-c...)
Affinity DataIC50:  2nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061862((S)-3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061859(2-(Butane-1-sulfonylamino)-3-{3-[(6-carbamimidoyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061847((S)-2-(Butane-1-sulfonylamino)-3-{3-[(5-carbamimid...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50082930(CHEMBL117662 | [6-(4-Carbamimidoyl-benzoylamino)-1...)
Affinity DataIC50:  2nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061839(2-(Butane-1-sulfonylamino)-3-{3-[(6-carbamimidoyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50006878((R)-1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of [125I]-labeled gastrin binding to gastrin receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)
Affinity DataIC50:  2.90nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132988(4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...)
Affinity DataIC50:  2.90nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50085605(CHEMBL126411 | [6-(4-Carbamimidoyl-2-fluoro-benzoy...)
Affinity DataIC50:  3nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50085612(CHEMBL126485 | [6-(4-Carbamimidoyl-2,6-difluoro-be...)
Affinity DataIC50:  5nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50006878((R)-1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132986(4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...)
Affinity DataIC50:  6.80nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)
Affinity DataIC50:  7.10nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50006878((R)-1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in mouse brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50085611(CHEMBL127680 | {6-[(6-Carbamimidoyl-pyridine-3-car...)
Affinity DataIC50:  9nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50006842(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-isopropox...)
Affinity DataIC50:  9.30nMAssay Description:Evaluated for inhibition of [125I]-CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 microM (in vi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50006842(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-isopropox...)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50085614(CHEMBL338485 | [6-(4-Carbamimidoyl-2-chloro-benzoy...)
Affinity DataIC50:  11nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50011943(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-dimethyla...)
Affinity DataIC50:  16nMAssay Description:Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061841(3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amin...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061848(3-{3-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-methy...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061864(3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amin...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50059694(7-[(6-Carbamimidoyl-1H-indazole-3-carbonyl)-amino]...)
Affinity DataIC50:  20nMAssay Description:Antagonism of fibrinogen binding to a purified human fibrinogen receptor preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50012827(10H-Phenoxazine | CHEMBL276850 | PHENOXAZINE)
Affinity DataIC50:  20nMAssay Description:Inhibition of [14C]-arachidonic acid conversion to 5-HETE by broken cell 5-lipoxygenase in vitro (guinea pig PMN)More data for this Ligand-Target Pair
In DepthDetails Article
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132981(4-[5-Methyl-3-(6-methyl-pyridin-2-yl)-1H-pyrazol-4...)
Affinity DataIC50:  24nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132993(4-(3-Phenyl-1H-pyrazol-4-yl)-quinoline | 4-(3-phen...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061862((S)-3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-...)
Affinity DataIC50:  25nMAssay Description:Inhibition of 20 uM ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50006838(2-[2-(1H-Indol-3-yl)-ethyl]-3-(3-isopropoxy-phenyl...)
Affinity DataIC50:  26nMAssay Description:Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50085607(CHEMBL126365 | [1-Oxo-6-((E)-3-piperidin-4-yl-acry...)
Affinity DataIC50:  26nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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