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Found 213 with Last Name = 'mckenzie' and Initial = 'a'
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401333(CHEMBL1230584)
Affinity DataKi:  0.200nMAssay Description:Binding affinity at recombinant Hsp90alpha incubated for 16 hrs by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM20800(2-amino-6-halopurine analogue, 20 | 6-chloro-9-[(4...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity at recombinant Hsp90alpha incubated for 16 hrs by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetEndoplasmin(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401333(CHEMBL1230584)
Affinity DataKi:  61nMAssay Description:Binding affinity at Grp94 incubated for 16 hrs by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein 75 kDa, mitochondrial(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401333(CHEMBL1230584)
Affinity DataKi:  255nMAssay Description:Binding affinity at TRAP1 incubated for 16 hrs by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401335(CHEMBL2205798)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401336(CHEMBL2205245)
Affinity DataIC50:  1nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401333(CHEMBL1230584)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401334(CHEMBL2205799)
Affinity DataIC50:  2nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50378702(CHEMBL560895 | SNX-2112)
Affinity DataIC50:  3nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401332(CHEMBL2205800)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM20800(2-amino-6-halopurine analogue, 20 | 6-chloro-9-[(4...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401337(CHEMBL2205244)
Affinity DataIC50:  6nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50161155(CHEMBL3793229)
Affinity DataIC50:  10nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50492323(CHEMBL2402205)
Affinity DataIC50:  33nMAssay Description:Displacement of MR121-Nrf2 from human N-terminal His-tagged Kelch-DC domain of Keap1 (321 to 609) expressed in Escherichia coli BL21 (DE3) after 40 m...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50161156(CHEMBL3793914)
Affinity DataIC50:  56nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50161154(CHEMBL3793036)
Affinity DataIC50:  72nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50161145(CHEMBL3793667)
Affinity DataIC50:  72nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165653((2-{4-[2-(3,4-Dichloro-phenylcarbamoyl)-vinyl]-2-f...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165660(2-(3-(5-(4-chlorophenyl)benzo[d]oxazol-2-yl)-4-(pr...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147546(2-(3-(5-(benzo[d][1,3]dioxol-5-yl)benzo[d]oxazol-2...)
Affinity DataIC50:  200nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165639((2-{4-[2-(2,4-Dichloro-phenylcarbamoyl)-vinyl]-2-f...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50161157(CHEMBL3792836)
Affinity DataIC50:  200nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147513(2-[3-[5-(4-Chloro-phenyl)-benzooxazol-2-yl]-4-(2-m...)
Affinity DataIC50:  200nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165669((2-{4-[2-(3-Bromo-phenylcarbamoyl)-vinyl]-2-fluoro...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...)
Affinity DataIC50:  204nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50161110(CHEMBL3792639)
Affinity DataIC50:  210nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50108881(CHEMBL3596591)
Affinity DataIC50:  220nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147534(1,3-Dioxo-2-[3-(5-phenyl-benzooxazol-2-yl)-4-propy...)
Affinity DataIC50:  250nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165640(2-(4-(5-(2-chloro-4-(3-(2,4-dichlorophenyl)acrylam...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165627((2-{4-[2-(3-Fluoro-4-methoxy-phenylcarbamoyl)-viny...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165638((2-{4-[2-(4-Cyano-phenylcarbamoyl)-vinyl]-2-fluoro...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165614((2-{4-[3-((E)-3-Chloro-2-fluoro-phenyl)-acryloylam...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165624((2-{4-[3-((E)-2,4-Dichloro-phenyl)-acryloylamino]-...)
Affinity DataIC50:  350nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165621((2-{2-Chloro-4-[3-((E)-2,4-dichloro-phenyl)-acrylo...)
Affinity DataIC50:  350nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165620(2-(4-(5-(2-chloro-4-(3-(4-methoxyphenyl)acrylamido...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165615((2-{4-[2-(2,4-Dichloro-phenylcarbamoyl)-vinyl]-phe...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165613((2-{4-[3-((E)-4-Bromo-phenyl)-acryloylamino]-2-chl...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165652((2-{4-[3-((E)-4-Bromo-phenyl)-acryloylamino]-3-flu...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165636(2-(4-(5-(4-(3-(4-bromophenyl)acrylamido)-2-chlorop...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165663((2-{4-[2-(4-Bromo-phenylcarbamoyl)-vinyl]-2-fluoro...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147537(2-(5-(5-(4-fluorophenyl)benzo[d]oxazol-2-yl)-2-met...)
Affinity DataIC50:  400nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147522(2-(4-(butylamino)-3-(5-phenylbenzo[d]oxazol-2-yl)p...)
Affinity DataIC50:  400nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147544(2-(2-methoxy-5-(5-(4-(trifluoromethoxy)phenyl)benz...)
Affinity DataIC50:  400nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147533(2-(5-(5-(3,5-difluorophenyl)benzo[d]oxazol-2-yl)-2...)
Affinity DataIC50:  400nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147539(2-(2-methoxy-5-(5-(4-methoxyphenyl)benzo[d]oxazol-...)
Affinity DataIC50:  450nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165642((4-{5-[2-Chloro-4-(3-phenyl-acryloylamino)-phenyl]...)
Affinity DataIC50:  450nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165643((2-{2-Fluoro-4-[2-(2-fluoro-4-methoxy-phenylcarbam...)
Affinity DataIC50:  450nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147517(2-[3-[5-(4-Fluoro-phenyl)-benzooxazol-2-yl]-4-(2-m...)
Affinity DataIC50:  500nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165659((2-{4-[2-(3-Bromo-phenylcarbamoyl)-vinyl]-phenyl}-...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional protein GlmU(Streptococcus pneumoniae)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50365095(CHEMBL1951184)
Affinity DataIC50:  500nMAssay Description:Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...More data for this Ligand-Target Pair
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