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Found 525 Enz. Inhib. hit(s) with Target = 'Heparanase'
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388329(CHEMBL2059500)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388343(CHEMBL2059243)
Affinity DataKi:  5.5nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388341(CHEMBL2059241)
Affinity DataKi:  5.80nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50614397(CHEMBL5279386)
Affinity DataKi:  6nMAssay Description:Binding affinity to heparanase (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388342(CHEMBL2059242)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388331(CHEMBL2059499)
Affinity DataKi:  6.10nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388345(CHEMBL2059245)
Affinity DataKi:  6.40nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378647(CHEMBL1627122 | PI-88)
Affinity DataKi:  7.90nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388332(CHEMBL2059498)
Affinity DataKi:  8.40nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388346(CHEMBL2059246)
Affinity DataKi:  8.5nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388335(CHEMBL2059503)
Affinity DataKi:  9.10nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388336(CHEMBL2059504)
Affinity DataKi:  9.10nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388330(CHEMBL2059247)
Affinity DataKi:  10.5nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388328(CHEMBL2059505)
Affinity DataKi:  11.3nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388334(CHEMBL2059501)
Affinity DataKi:  16nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388333(CHEMBL2059502)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388344(CHEMBL2059244)
Affinity DataKi:  22.3nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388340(CHEMBL2059510)
Affinity DataKi:  30nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388338(CHEMBL2059508)
Affinity DataKi:  111nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50375292(CHEMBL407200)
Affinity DataKi:  200nMAssay Description:Inhibition of human platelet heparanase by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50375290(CHEMBL279625)
Affinity DataKi:  240nMAssay Description:Inhibition of human platelet heparanase by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50375291(CHEMBL439118)
Affinity DataKi:  280nMAssay Description:Inhibition of human platelet heparanase by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50375287(CHEMBL260220)
Affinity DataKi:  2.23E+3nMAssay Description:Inhibition of human platelet heparanase by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Mus musculus)
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataKi:  4.80E+4nMAssay Description:Inhibition of mouse B16-BL6 cells derived heparanase using [3H]HS as substrate after 6 hrs by size exclusion chromatography based liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50375287(CHEMBL260220)
Affinity DataKi:  6.83E+4nMAssay Description:Inhibition of human platelet heparanase by uncompetitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50614394(CHEMBL5273238)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of human heparanase using fondaparinux as substrate incubated for 18 hrs by Polymer-H fluorescence assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50614394(CHEMBL5273238)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of heparanase (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50466629(CHEMBL4280766)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant HPSE (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50611959(CHEMBL5276024)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human heparanase incubated for 4 hrs by beta-scintillation counter analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50612819(CHEMBL5291042)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human HPSE expressed in insect cells by fondaparinux assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50611973(CHEMBL5282692)
Affinity DataIC50:  12nMAssay Description:Inhibition of HPSE (unknown origin) using fondaparinux as substrate incubated for 18 hrs by fluorescence plate reader analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50614397(CHEMBL5279386)
Affinity DataIC50:  12nMAssay Description:Inhibition of heparanase (unknown origin) incubated for 18 hrs by fondaparinux assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093526(CHEMBL426373 | RK-682)
Affinity DataIC50:  17nMAssay Description:Inhibition of HPSE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50431651(CHEMBL2349236)
Affinity DataIC50:  17nMAssay Description:Inhibition of HPSE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50612820(CHEMBL5267246)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human HPSE expressed in insect cells by fondaparinux assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50611974(CHEMBL5271999)
Affinity DataIC50:  20nMAssay Description:Inhibition of HPSE (unknown origin) using fondaparinux as substrate incubated for 18 hrs by fluorescence plate reader analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50614398(CHEMBL5268939)
Affinity DataIC50:  20nMAssay Description:Inhibition of heparanase (unknown origin) incubated for 18 hrs by fondaparinux assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175932(1,3-bis-[4-(5,6-dimethyl-1H-benzoimidazol-2-yl)phe...)
Affinity DataIC50:  75nMAssay Description:Inhibitory activity against heparanase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175932(1,3-bis-[4-(5,6-dimethyl-1H-benzoimidazol-2-yl)phe...)
Affinity DataIC50:  75nMAssay Description:Inhibition of recombinant heparanase catalytic stie (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50466636(CHEMBL4286441)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant HPSE (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104680(3-Hexadecanoyl-5-hydroxymethyl-4-methoxy-5H-furan-...)
Affinity DataIC50: >100nMAssay Description:Inhibition of HPSE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50611970(CHEMBL5286960)
Affinity DataIC50: >100nMAssay Description:Inhibition of HPSE (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50431662(CHEMBL2349246)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant heparanase catalytic stie (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175931(1-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-3-(4-(7-met...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against heparanase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175938(1,3-bis(4-(7-methyl-1H-benzo[d]imidazol-2-yl)pheny...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against heparanase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175936(1,3-bis(4-(6-methyl-1H-benzo[d]imidazol-2-yl)pheny...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against heparanase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50506597(CHEMBL4576477)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant HPSE GS3 (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 based colorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50466651(CHEMBL4283251)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant HPSE (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50412102(CHEMBL495255)
Affinity DataIC50:  200nMAssay Description:Inhibition of human heparanase assessed as reduction in basic fibroblast growth factor binding incubated for 2 hrs by microplate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147546(2-(3-(5-(benzo[d][1,3]dioxol-5-yl)benzo[d]oxazol-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human heparanase assessed as reduction in basic fibroblast growth factor binding incubated for 2 hrs by microplate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
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