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Found 117 with Last Name = 'mcmahon' and Initial = 'jb'
TargetProtein kinase C alpha/beta/gamma/delta/epsilon/eta/theta type/Serine/threonine-protein kinase D1/D3(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50368315(PROSTRATIN)
Affinity DataKi:  190nMAssay Description:Displacement of [3H]PDBu binding to Protein kinase C of CEM cells with 10% fetal calf serumMore data for this Ligand-Target Pair
TargetProtein kinase C zeta type(Rattus norvegicus)
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50478518(CHEMBL514017)
Affinity DataIC50:  17nMAssay Description:Displacement of [3H]PDBu from rat brain membrane PKCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50295171(AILANTHINONE | CHEMBL487194)
Affinity DataIC50:  32nMAssay Description:Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50349194(GLAUCARUBINONE | NSC-14975)
Affinity DataIC50:  40nMAssay Description:Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50295170(6R-senecionylchaparrin | CHEMBL564009)
Affinity DataIC50:  71nMAssay Description:Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50190657(CHEMBL1194747)
Affinity DataIC50:  730nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32628(FTC | Fumitremorgin C)
Affinity DataIC50:  790nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32628(FTC | Fumitremorgin C)
Affinity DataIC50:  800nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death protein 4(Homo sapiens (Human))
Yunnan University

Curated by ChEMBL
LigandPNGBDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)
Affinity DataIC50:  880nMAssay Description:Stabilization of Pdcd4 expressed in human HEK293 cells assessed as inhibition of TPA-induced degradation by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50341205(CHEMBL1765574 | nagilactone F)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of TPA-induced AP-1 activation in cells expressing beta-lactamase after 18 hrs using FRET substrate by cell-based high-throughput screenin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50190661(CHEMBL3901938)
Affinity DataIC50:  1.90E+3nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50190659(CHEMBL3912024)
Affinity DataIC50:  2.20E+3nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50190656(CHEMBL3910426)
Affinity DataIC50:  2.40E+3nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32630(NSC19139)
Affinity DataIC50:  2.60E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM19460((2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32637(NSC375985)
Affinity DataIC50:  3.70E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50269764((+)-Discorhabdin B | CHEMBL459120 | Discorhabdin A...)
Affinity DataIC50:  3.70E+3nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32633(NSC168201)
Affinity DataIC50:  3.90E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50341206(CHEMBL1765575 | inumakilactone)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of TPA-induced AP-1 activation in cells expressing beta-lactamase after 18 hrs using FRET substrate by cell-based high-throughput screenin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50339152((S)-2-(3,5-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32632(NSC120688)
Affinity DataIC50:  4.30E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32629(NSC11668 | cid_223753)
Affinity DataIC50:  4.50E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32636(NSC320852)
Affinity DataIC50:  4.60E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50352478(CHEMBL1823866)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of AP1 expressed in HEK293T cells coexpressing beta-lactamase pre-incubated 1 hr before TPA addition measured 18 hrs post TPA challenge by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32635(NSC306698)
Affinity DataIC50:  5.40E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064888(3',5-dihydroxy-3,4',7-trimethoxyflavone | 5-hydrox...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50339155(6-(3,7-dimethylocta-2,6-dienyl)-3,5,7-trihydroxy-2...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32634(NSC303769)
Affinity DataIC50:  5.80E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50321556(8-hydroxy-5,10-dimethoxy-2-propyl-4H-benzo[h]chrom...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50352479(CHEMBL1823867)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of AP1 expressed in HEK293T cells coexpressing beta-lactamase pre-incubated 1 hr before TPA addition measured 18 hrs post TPA challenge by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50339159(5-Hydroxy-3-(4-hydroxy-3-methyl-but-2-enyl)-8,8-di...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50339151((2S)-5,7,3'-trihydroxy-4'-methoxy-8-(3''-methylbut...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32624(Botryllamide G, 7 | US8470888, Botryllamide G)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32624(Botryllamide G, 7 | US8470888, Botryllamide G)
Affinity DataIC50:  6.90E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50312636((-)-Makaluvamine F | CHEMBL509890 | Makaluvamine F)
Affinity DataIC50:  8.30E+3nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50339158(5,7,3'-trihydroxy-3,5'-dimethoxy-2'-(3'-methylbut-...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50221718(CHEMBL400538 | comaparvin)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32631(Digitonin | NSC23471)
Affinity DataIC50:  9.70E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32619(Botryllamide B, 2)
Affinity DataIC50:  1.12E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32617(Botryllamide A, 1 | US8470888, Botryllamide A)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32638(Dihydroergocristine | NSC409663)
Affinity DataIC50:  1.18E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50321557(5,8-dihydroxy-6,10-dimethoxy-2-methyl-4H-benzo[h]c...)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50339156((S)-8-(3,7-dimethylocta-2,6-dienyl)-5,7-dihydroxy-...)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50242177(5,8-dihydroxy-10-methoxy-2-methyl-4H-benzo[h]chrom...)
Affinity DataIC50:  1.28E+4nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50339153((2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethyloct...)
Affinity DataIC50:  1.55E+4nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32620(Botryllamide C, 3 | US8470888, Botryllamide D)
Affinity DataIC50:  1.64E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32621(Botryllamide D, 4)
Affinity DataIC50:  1.64E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50321555(6-methoxycomaparvin 5-methyl ether | CHEMBL256967)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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