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Found 1159 with Last Name = 'mei' and Initial = 'h'
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bayer Healthcare

Curated by PDSP Ki Database
LigandPNGBDBM21244(2-[(1S,2S,5S)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Affinity DataKi:  0.510nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bayer Healthcare

Curated by PDSP Ki Database
LigandPNGBDBM21244(2-[(1S,2S,5S)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Affinity DataKi:  0.540nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Bayer Healthcare

Curated by PDSP Ki Database
LigandPNGBDBM21244(2-[(1S,2S,5S)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Affinity DataKi:  1.15nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bayer Healthcare

Curated by PDSP Ki Database
LigandPNGBDBM86515(CAS_1972-08-3 | NSC_16078 | THC, delta 9 | US94161...)
Affinity DataKi:  13.7nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bayer Healthcare

Curated by PDSP Ki Database
LigandPNGBDBM86515(CAS_1972-08-3 | NSC_16078 | THC, delta 9 | US94161...)
Affinity DataKi:  22.9nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bayer Healthcare

Curated by PDSP Ki Database
LigandPNGBDBM86514(BAY 59-3074 | CAS_406205-74-1 | CHEMBL1354658)
Affinity DataKi:  45.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Bayer Healthcare

Curated by PDSP Ki Database
LigandPNGBDBM86514(BAY 59-3074 | CAS_406205-74-1 | CHEMBL1354658)
Affinity DataKi:  55.4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Bayer Healthcare

Curated by PDSP Ki Database
LigandPNGBDBM86515(CAS_1972-08-3 | NSC_16078 | THC, delta 9 | US94161...)
Affinity DataKi:  69.7nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Academia Sinica

Curated by ChEMBL
LigandPNGBDBM50105934(2-(6-Amino-purin-7-ylmethoxy)-ethanol | CHEMBL1260...)
Affinity DataKi:  8.30E+3nMAssay Description:Inhibitory activity against adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Academia Sinica

Curated by ChEMBL
LigandPNGBDBM50369958(CHEMBL1790862)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibitory activity against adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Academia Sinica

Curated by ChEMBL
LigandPNGBDBM50029650(2-(6-Amino-purin-9-ylmethoxy)-ethanol | CHEMBL3775...)
Affinity DataKi:  1.40E+5nMAssay Description:Inhibitory activity against adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoribosyl pyrophosphate synthase-associated protein 2(Homo sapiens (Human))
Academia Sinica

Curated by ChEMBL
LigandPNGBDBM50369958(CHEMBL1790862)
Affinity DataKi:  7.90E+5nMAssay Description:Inhibitory activity against PRPP synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Academia Sinica

Curated by ChEMBL
LigandPNGBDBM50369957(CHEMBL1790864)
Affinity DataKi: >8.00E+5nMAssay Description:Inhibitory activity against adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Academia Sinica

Curated by ChEMBL
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataKi: >8.00E+5nMAssay Description:Inhibitory activity against adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Academia Sinica

Curated by ChEMBL
LigandPNGBDBM50105931(CHEMBL123655 | [2-(6-Amino-purin-7-yl)-ethoxymethy...)
Affinity DataKi: >8.00E+5nMAssay Description:Inhibitory activity against adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Academia Sinica

Curated by ChEMBL
LigandPNGBDBM50105935(CHEMBL121723 | [2-(6-Amino-purin-9-yl)-ethoxymethy...)
Affinity DataKi: >8.00E+5nMAssay Description:Inhibitory activity against adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoribosyl pyrophosphate synthase-associated protein 2(Homo sapiens (Human))
Academia Sinica

Curated by ChEMBL
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataKi:  3.00E+6nMAssay Description:Inhibitory activity against PRPP synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoribosyl pyrophosphate synthase-associated protein 2(Homo sapiens (Human))
Academia Sinica

Curated by ChEMBL
LigandPNGBDBM50105931(CHEMBL123655 | [2-(6-Amino-purin-7-yl)-ethoxymethy...)
Affinity DataKi:  1.70E+7nMAssay Description:Inhibitory activity against PRPP synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Schering

Curated by ChEMBL
LigandPNGBDBM50409115(LONAPRISAN)
Affinity DataIC50:  0.00250nMAssay Description:In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-B progesterone receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Schering

Curated by ChEMBL
LigandPNGBDBM50409115(LONAPRISAN)
Affinity DataIC50:  0.00360nMAssay Description:In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-A progesterone receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Schering

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  0.0250nMAssay Description:In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-B progesterone receptorMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Schering

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  0.0280nMAssay Description:In vitro antgonist potency in transactivation assay in neuroblastoma cells expressing human PR-A progesterone receptorMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50228403((R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-met...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human DPP4 preincubated for 30 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A1(Homo sapiens (Human))
Bayer Schering Pharma

Curated by ChEMBL
LigandPNGBDBM50327343(2-(4-(8-fluoroquinoxalin-6-yl)-3-methyl-1-o-tolyl-...)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at adenosine A1 receptor by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetchymase(Mesocricetus auratus (Golden hamster))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255962(US9481672, 140)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetchymase(Mesocricetus auratus (Golden hamster))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255964(US9481672, 142)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ERK2 (unknown origin) using peptide substrate measured after 45 mins by IMAP assayMore data for this Ligand-Target Pair
TargetAdenosine kinase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50143581(7-[4-(4-Fluoro-benzyl)-[1,4]diazepan-1-yl]-2-pheny...)
Affinity DataIC50: >1nMAssay Description:Inhibitory activity against human adenosine kinase expressed in E. coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50143575(7-(1-Benzyl-hexahydro-pyrrolo[3,4-b]pyrrol-5-yl)-2...)
Affinity DataIC50: >1nMAssay Description:Inhibitory activity against human adenosine kinase expressed in E. coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50143574(7-((4aS,7aS)-6-Benzyl-octahydro-pyrrolo[3,4-b]pyri...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against human adenosine kinase expressed in E. coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetchymase(Mesocricetus auratus (Golden hamster))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256099(US9481672, 281)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetchymase(Mesocricetus auratus (Golden hamster))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256065(US9481672, 247)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetchymase(Mesocricetus auratus (Golden hamster))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256064(US9481672, 246)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetchymase(Mesocricetus auratus (Golden hamster))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256036(US9481672, 217)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetchymase(Mesocricetus auratus (Golden hamster))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255968(US9481672, 146)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium channel subfamily K member 9(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM458963((4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]me...)
Affinity DataIC50:  1.04nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50464538(CHEMBL4289577)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Flt-3 (unknown origin) using poly(Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Bayer Schering Pharma

Curated by ChEMBL
LigandPNGBDBM50327327(2-(4-(4-fluorophenyl)-3-methyl-1-o-tolyl-1H-pyrazo...)
Affinity DataIC50:  1.39nMAssay Description:Antagonist activity at adenosine A1 receptor by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50143592(7-((3aS,6aS)-1-Benzyl-hexahydro-pyrrolo[3,4-b]pyrr...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against human adenosine kinase expressed in E. coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of cMET (unknown origin) using poly(Glu,Tyr) 4:1 substrate after 30 mins by HTFR analysisMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Bayer Yakuhin

Curated by ChEMBL
LigandPNGBDBM50344356(CHEMBL1779676 | ethyl 3-(3-(7-hydroxynaphthalen-1-...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM60417(US9051329, Example 1)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human DPP4 preincubated for 30 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50458811(CHEMBL4209570)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of ERK2 (unknown origin) using peptide substrate measured after 45 mins by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Bayer Yakuhin

Curated by ChEMBL
LigandPNGBDBM50344356(CHEMBL1779676 | ethyl 3-(3-(7-hydroxynaphthalen-1-...)
Affinity DataIC50:  1.70nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50464538(CHEMBL4289577)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PDGFRbeta (unknown origin) using poly(Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Targetchymase(Mesocricetus auratus (Golden hamster))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM88376(US9695131, 13)
Affinity DataIC50:  1.80nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Bayer Yakuhin

Curated by ChEMBL
LigandPNGBDBM50344367(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-hydrox...)
Affinity DataIC50:  1.90nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50464538(CHEMBL4289577)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of cMET (unknown origin) using poly(Glu,Tyr) 4:1 substrate after 30 mins by HTFR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Targetchymase(Mesocricetus auratus (Golden hamster))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256088(BDBM256092 | BDBM256093 | US9481672, 270)
Affinity DataIC50:  2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetchymase(Mesocricetus auratus (Golden hamster))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256083(US9481672, 265)
Affinity DataIC50:  2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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