BindingDB PrimarySearch_ki

Found 1287 with Last Name = 'migliore' and Initial = 'm'

Prostaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent

PNG

BDBM50153378(CHEMBL3775041 | US9630914, Compound 12)

IC50: 0.0100nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details US Patent

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612206(CHEMBL5277668)

IC50: <0.200nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612230(CHEMBL5270706)

IC50: <0.200nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612227(CHEMBL5289675)

IC50: <0.200nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612226(CHEMBL5281154)

IC50: <0.200nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612225(CHEMBL5286893)

IC50: <0.200nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612209(CHEMBL5288427)

IC50: <0.200nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612208(CHEMBL5284027)

IC50: <0.200nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612231(CHEMBL5280373)

IC50: <0.200nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612226(CHEMBL5281154)

IC50: <0.200nMAssay Description:Inhibition of N-terminal GST-fused human wild type LRRK2 using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612206(CHEMBL5277668)

IC50: <0.200nMAssay Description:Inhibition of N-terminal GST-fused human wild type LRRK2 using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612225(CHEMBL5286893)

IC50: <0.200nMAssay Description:Inhibition of N-terminal GST-fused human wild type LRRK2 using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Prostaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent

PNG

BDBM50153360(CHEMBL3774784)

IC50: 0.290nMAssay Description:Inhibition of ovine COX1 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substra...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612230(CHEMBL5270706)

IC50: 0.300nMAssay Description:Inhibition of N-terminal GST-fused human wild type LRRK2 using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612207(CHEMBL5274608)

IC50: 0.400nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612205(CHEMBL5279036)

IC50: 0.440nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612209(CHEMBL5288427)

IC50: 0.530nMAssay Description:Inhibition of N-terminal GST-fused human wild type LRRK2 using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612208(CHEMBL5284027)

IC50: 0.700nMAssay Description:Inhibition of N-terminal GST-fused human wild type LRRK2 using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612229(CHEMBL5280577)

IC50: 0.800nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612223(CHEMBL5279816)

IC50: 0.820nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612207(CHEMBL5274608)

IC50: 0.880nMAssay Description:Inhibition of N-terminal GST-fused human wild type LRRK2 using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612230(CHEMBL5270706)

IC50: 1nMAssay Description:Inhibition of human LRRK2 G2019S mutant expressed in HEK293 cells assessed as reduction in pS1292 phosphorylation incubated for 2 hrs by MSD analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612227(CHEMBL5289675)

IC50: 1nMAssay Description:Inhibition of N-terminal GST-fused human wild type LRRK2 using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612230(CHEMBL5270706)

IC50: 1.10nMAssay Description:Inhibition of human LRRK2 G2019S mutant expressed in HEK293 cells assessed as reduction in pSer935 phosphorylation incubated for 2 hrs by HTRF analys...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612226(CHEMBL5281154)

IC50: 1.20nMAssay Description:Inhibition of human LRRK2 G2019S mutant expressed in HEK293 cells assessed as reduction in pS1292 phosphorylation incubated for 2 hrs by MSD analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612230(CHEMBL5270706)

IC50: 1.5nMAssay Description:Inhibition of human LRRK2 G2019S mutant expressed in HEK293 cells assessed as reduction in pSer935 phosphorylation incubated for 2 hrs by immunoblott...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612221(CHEMBL5289513)

IC50: 1.60nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Fatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL

PNG

BDBM26739(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)

IC50: 1.70nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid Patents Similars

Details Article PubMed

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612231(CHEMBL5280373)

IC50: 1.70nMAssay Description:Inhibition of human LRRK2 G2019S mutant expressed in HEK293 cells assessed as reduction in pS1292 phosphorylation incubated for 2 hrs by MSD analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612226(CHEMBL5281154)

IC50: 2.40nMAssay Description:Inhibition of human LRRK2 G2019S mutant expressed in HEK293 cells assessed as reduction in pSer935 phosphorylation incubated for 2 hrs by HTRF analys...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612210(CHEMBL5271931)

IC50: 2.40nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612231(CHEMBL5280373)

IC50: 2.5nMAssay Description:Inhibition of human LRRK2 G2019S mutant expressed in HEK293 cells assessed as reduction in pSer935 phosphorylation incubated for 2 hrs by immunoblott...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Fatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL

PNG

BDBM50153438(CHEMBL3774873 | US9630914, Example 14)

IC50: 2.60nMAssay Description:Rat FAAH was prepared from male Sprague Dawley rat brains, homogenized in a potter in 20 mM of Tris HCl pH 7.4, 0.32 M sucrose.The radiometric assay ...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid

Details US Patent

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612219(CHEMBL5286615)

IC50: 2.60nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Fatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL

PNG

BDBM50153438(CHEMBL3774873 | US9630914, Example 14)

IC50: 3nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Fatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL

PNG

BDBM50153356(CHEMBL3774686)

IC50: 3nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Acid ceramidase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL

PNG

BDBM50511300(CHEMBL4580541)

IC50: 3nMAssay Description:Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612212(CHEMBL5288038)

IC50: 3nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Fatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL

PNG

BDBM50153445(CHEMBL3775280 | US9630914, Example 15)

IC50: 3nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612231(CHEMBL5280373)

IC50: 3.10nMAssay Description:Inhibition of human LRRK2 G2019S mutant expressed in HEK293 cells assessed as reduction in pSer935 phosphorylation incubated for 2 hrs by HTRF analys...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Fatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL

PNG

BDBM50153445(CHEMBL3775280 | US9630914, Example 15)

IC50: 3.30nMAssay Description:Rat FAAH was prepared from male Sprague Dawley rat brains, homogenized in a potter in 20 mM of Tris HCl pH 7.4, 0.32 M sucrose.The radiometric assay ...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details US Patent

Fatty-acid amide hydrolase 1(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

US Patent

PNG

BDBM50153438(CHEMBL3774873 | US9630914, Example 14)

IC50: 4nMAssay Description:Human recombinant FAAH was obtained from a HEK-293 FAAH-1 overexpressing stable cell line. Cells were grown in DMEM medium containing 10% FBS, 1% pen...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details US Patent

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612230(CHEMBL5270706)

IC50: 4.70nMAssay Description:Inhibition human LRRK2 G2019S mutant expressed in human HEK293 assessed as Rab10 substrate phosphorylation at Threonine 73 residue incubated for 2 hr...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Acid ceramidase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL

PNG

BDBM50556798(CHEMBL4742096)

IC50: 5nMAssay Description:Inhibition of human acid ceramidase using N-lauroyl ceramide incubated for 1 hr by LC/MS analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Fatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL

PNG

BDBM50153354(CHEMBL3775510)

IC50: 5nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612219(CHEMBL5286615)

IC50: 5.70nMAssay Description:Inhibition of N-terminal GST-fused human wild type LRRK2 using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Acid ceramidase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL

PNG

BDBM50511282(CHEMBL4592427)

IC50: 6nMAssay Description:Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Fatty-acid amide hydrolase 1(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

US Patent

PNG

BDBM50153379(CHEMBL3775979 | US9630914, Example 13)

IC50: 6nMAssay Description:Human recombinant FAAH was obtained from a HEK-293 FAAH-1 overexpressing stable cell line. Cells were grown in DMEM medium containing 10% FBS, 1% pen...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details US Patent

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612211(CHEMBL5266676)

IC50: 6nMAssay Description:Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))TBA

PNG

BDBM50612231(CHEMBL5280373)

IC50: 6.60nMAssay Description:Inhibition of N-terminal GST-fused human wild type LRRK2 using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Displayed 1 to 50 (of 1287 total ) | Next | Last >>

Filter my 1287 hits

Targets 8▿
- Leucine-rich repeat serine/threonine-protein kinase 2 461
- Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] 335
- Prostaglandin G/H synthase 1 105
- Prostaglandin G/H synthase 2 103
- Fatty-acid amide hydrolase 1 [30-579] 101
- Acid ceramidase 93
- N-acylethanolamine-hydrolyzing acid amidase 66
- Fatty-acid amide hydrolase 1 23
- ...
Publications 7▿
- US Patent US11427558 (2022) 670
- J Med Chem 55: 8807-26 (2012) 125
- Eur J Med Chem 109: 216-37 (2016) 120
- US Patent US9630914 (2017) 86
- US Patent US10556892 (2020) 65
- J Med Chem 63: 3634-3664 (2020) 48
- J Med Chem 63: 15821-15851 (2020) 47
Institutions 5▿
- Escape Bio 670
- Fondazione Istituto Italiano Di Tecnologia 253
- Istituto Italiano Di Tecnologia 125
- The Regents of The University of California 65
- University Of Illinois At Chicago 48
Affinity: 0.010 to 3.0E+7 nM▿
- IC50 1285
- EC50 1
- Affinity ≤ nM
Xtal structures: 8
Docked structures: 0
Catalog Cmpds: 21