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Found 717 with Last Name = 'miller' and Initial = 'ln'
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21301(7-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramet...)
Affinity DataKi:  0.120nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21291(6-methyl-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetrameth...)
Affinity DataKi:  0.150nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21284(1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopr...)
Affinity DataKi:  0.210nM EC50:  9.5nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM85093(CAS_3853 | CHEMBL267014 | CHEMBL555670 | L 745,870...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against human Dopamine receptor D4 by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21334(1-(oxan-4-ylmethyl)-6-phenyl-3-[(2,2,3,3-tetrameth...)
Affinity DataKi:  0.410nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21300(6-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramet...)
Affinity DataKi:  0.510nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21290(6-bromo-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethy...)
Affinity DataKi:  0.650nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153255(2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-N-m-tolyl-...)
Affinity DataKi:  0.700nMAssay Description:In vitro ability to inhibit [3H]-spiperone binding to human Dopamine receptor D4.4 alleleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21307(6-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramet...)
Affinity DataKi:  0.700nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21304(6-(benzyloxy)-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetr...)
Affinity DataKi:  0.880nM EC50:  167nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21309(5-(oxan-4-ylmethyl)-7-[(2,2,3,3-tetramethylcyclopr...)
Affinity DataKi:  1nM EC50:  29.5nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  1.30nM EC50:  125nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50200028(2-methoxy-N-(3',4',5',6'-tetrahydro-2'H-[2,4'-bipy...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]A369508 from human D4 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21303(5-(benzyloxy)-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetr...)
Affinity DataKi:  1.30nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.40nMAssay Description:In vitro ability to inhibit [3H]-spiperone binding to human Dopamine receptor D4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21333(Tetrahydropyranyl-methyl analogue, 54 | methyl 1-(...)
Affinity DataKi:  1.40nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi:  1.5nMAssay Description:In vitro binding affinity tested on HEK293 cells co-transfected with human D4.4 receptor using [3H]spiperone as a radioligand in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21286(5-fluoro-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetrameth...)
Affinity DataKi:  1.60nM EC50:  36.5nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153255(2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-N-m-tolyl-...)
Affinity DataKi:  1.80nMAssay Description:In vitro ability to inhibit [3H]-6b binding to human Dopamine receptor D4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21306(5-(benzyloxy)-6-methoxy-1-(oxan-4-ylmethyl)-3-[(2,...)
Affinity DataKi:  1.80nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.90nMAssay Description:In vitro ability to inhibit [3H]-6b binding to human Dopamine receptor D4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21295(1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopr...)
Affinity DataKi:  1.90nM EC50:  11nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21289(6-chloro-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetrameth...)
Affinity DataKi:  2.5nM EC50:  21nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153259(2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[...)
Affinity DataKi:  2.70nMAssay Description:In vitro ability to inhibit [3H]-spiperone binding to human Dopamine receptor D4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50102712(2-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-pyraz...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity against human Dopamine receptor D4 by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21317(4-{2-[6-(benzyloxy)-3-[(2,2,3,3-tetramethylcyclopr...)
Affinity DataKi:  2.90nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21287(5-chloro-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetrameth...)
Affinity DataKi:  3nM EC50:  132nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21293(6-methanesulfonyl-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-...)
Affinity DataKi:  3nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21305(7-(benzyloxy)-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetr...)
Affinity DataKi:  3.10nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21297(1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopr...)
Affinity DataKi:  3.20nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21298(4-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramet...)
Affinity DataKi:  3.30nM EC50:  91nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21292(1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopr...)
Affinity DataKi:  3.5nM EC50: >1.00E+4nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [125I]7-OH-PIPAT from human D2L receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50145073(5-Fluoro-2-(4-pyridin-2-yl-piperazin-1-ylmethyl)-1...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity towards human D4.4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150143(2-[4-(2,5-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi:  3.80nMAssay Description:In vitro binding affinity tested on HEK293 cells co-transfected with human D4.4 receptor using [3H]spiperone as a radioligand in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21294(1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopr...)
Affinity DataKi:  3.90nM EC50:  73nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50145078(2-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-1H-b...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity against human Dopamine receptor D4 by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21311(4-(2-{3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]...)
Affinity DataKi:  4.40nM EC50:  17.5nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21299(5-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramet...)
Affinity DataKi:  4.60nM EC50:  101nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21285(4,5,6,7-tetrafluoro-1-(oxan-4-ylmethyl)-3-[(2,2,3,...)
Affinity DataKi:  5nM EC50:  40nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21331(1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopr...)
Affinity DataKi:  5nM EC50:  53nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193321((Z)-1-(3,5-difluorophenyl)-3-(4-pyridin-2-ylpipera...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]A-369508 from human recombinant D4.4 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193331((E)-1-(3,4-dichlorophenyl)-3-(4-pyridin-2-ylpipera...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]A-369508 from human recombinant D4.4 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193296((Z)-1-(3-fluorophenyl)-3-(4-pyridin-2-ylpiperazin-...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]A-369508 from human recombinant D4.4 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21288(5-bromo-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethy...)
Affinity DataKi:  6.60nM EC50:  391nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193330((E)-3-(4-pyridin-2-ylpiperazin-1-yl)-1-(m-tolyl)pr...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]A-369508 from human recombinant D4.4 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50200037(2-(3',4',-5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]A369508 from human D4 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50145081(2-[4-(2-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-be...)
Affinity DataKi:  8.5nMAssay Description:Binding affinity against human Dopamine receptor D4 by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21296(1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopr...)
Affinity DataKi:  8.5nM EC50:  18.5nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50145081(2-[4-(2-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-be...)
Affinity DataKi:  8.5nMAssay Description:Binding affinity against human Dopamine receptor D4 by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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