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Found 277 with Last Name = 'mimura' and Initial = 't'
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008612(CHEMBL154588 | Sodium; 3-(2-mercaptomethyl-3-pheny...)
Affinity DataIC50:  0.270nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008616(CHEMBL157625 | Sodium; 2-(2-mercaptomethyl-3-pheny...)
Affinity DataIC50:  0.820nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008595(CHEMBL351330 | Sodium; 4-(2-mercaptomethyl-4-methy...)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167609((2R,5R)-1-[4-(2,4-Dichloro-benzyloxy)-benzenesulfo...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant aggrecanase 1 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008602(CHEMBL435444 | Sodium; 4-(2-mercaptomethyl-3-p-tol...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341824((1S,2R,3R)-2-Methyl-1-[5-(4-methylpyrazol-1-yl)thi...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341816((1S,2R,3R)-1-[5-(4-Methoxypyrazol-1-yl)thiophene-2...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167609((2R,5R)-1-[4-(2,4-Dichloro-benzyloxy)-benzenesulfo...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008605(CHEMBL157663 | Sodium; 2-(2-mercaptomethyl-3-pheny...)
Affinity DataIC50:  1.5nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008590(CHEMBL154774 | Sodium; 4-(2-mercaptomethyl-3-pheny...)
Affinity DataIC50:  1.70nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008603((2-Mercaptomethyl-3-phenyl-propionylamino)-methane...)
Affinity DataIC50:  2.20nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008591(CHEMBL346587 | Sodium; 3-(2-mercaptomethyl-4-methy...)
Affinity DataIC50:  2.40nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008599(CHEMBL155953 | Sodium; 3-(2-mercaptomethyl-3-p-tol...)
Affinity DataIC50:  2.5nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  2.60nMAssay Description:The compound was tested in vitro for its inhibitory activity against Enkephalinase enzymeMore data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341819((1S,2R,3R)-1-(6-Chloro-4H-thieno[3,2-b]indole-2-su...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963((2S,3R)-2-(cyclopropylmethylamino)-N1-hydroxy-N4-(...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant aggrecanase 1 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008618(CHEMBL155417 | Sodium; 2-(2-mercaptomethyl-3-p-tol...)
Affinity DataIC50:  3.10nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008589(CHEMBL155783 | Sodium; 4-[2-mercaptomethyl-3-(4-me...)
Affinity DataIC50:  3.20nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50311088(CHEMBL1078281 | cis-rac-1-(5-(4-chloro-1H-pyrazol-...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50311088(CHEMBL1078281 | cis-rac-1-(5-(4-chloro-1H-pyrazol-...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human recombinant MMP13 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008623(CHEMBL440183 | Sodium; 2-[3-(4-fluoro-phenyl)-2-me...)
Affinity DataIC50:  3.5nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50311088(CHEMBL1078281 | cis-rac-1-(5-(4-chloro-1H-pyrazol-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant aggrecanase 1 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008600(CHEMBL156374 | Sodium; 2-(2-mercaptomethyl-3-pheny...)
Affinity DataIC50:  4.40nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008609(CHEMBL347390 | Sodium; 2-[2-mercaptomethyl-3-(4-me...)
Affinity DataIC50:  4.40nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008622(CHEMBL158345 | Sodium; 4-[3-(4-fluoro-phenyl)-2-me...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008607(CHEMBL154766 | Sodium; 2-(2-mercaptomethyl-4-methy...)
Affinity DataIC50:  5.20nMAssay Description:The compound was tested in vitro for its inhibitory activity against Enkephalinase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008620(CHEMBL156012 | Sodium; 3-(2-mercaptomethyl-3-pheny...)
Affinity DataIC50:  5.40nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50311088(CHEMBL1078281 | cis-rac-1-(5-(4-chloro-1H-pyrazol-...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008610(CHEMBL156013 | Sodium; 4-(2-mercaptomethyl-3-pheny...)
Affinity DataIC50:  7.40nMAssay Description:The compound was tested in vitro for its inhibitory activity against Enkephalinase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50311088(CHEMBL1078281 | cis-rac-1-(5-(4-chloro-1H-pyrazol-...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of ADAMTS5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341820((1S,2R,3R)-1-(6-Fluoro-4H-thieno[3,2-b]indole-2-su...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341820((1S,2R,3R)-1-(6-Fluoro-4H-thieno[3,2-b]indole-2-su...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341812((1S,2R,3R)-2.3-Dimethyl-1-(8-fluoro-1,2,3,4-tetrah...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008597(CHEMBL156099 | Sodium; 2-(2-mercaptomethyl-3-napht...)
Affinity DataIC50:  8.40nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341809((1S,2R,3R)-1-(7-Fluoro-1,2,3,4-tetrahydropyrido[3'...)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341813((1S,2R,3R)-2,3-Dimethyl-1-(7-fluoro-1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50311084((1S,2R)-1-(5-(4-chlorophenyl)thiophene-2-sulfonami...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ADAMTS5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341821((1S,2R,3R)-1-(7-Fluoro-4H-thieno[3,2-b]indole-2-su...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008615(2-(2-Mercaptomethyl-5-phenyl-pentanoylamino)-ethan...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008613(CHEMBL157079 | Sodium; 4-[(2-mercaptomethyl-3-phen...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008617(CHEMBL156757 | Sodium; 4-(3-benzo[d]isoxazol-3-yl-...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104963((2S,3R)-2-(cyclopropylmethylamino)-N1-hydroxy-N4-(...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008606(CHEMBL155779 | Sodium; 4-[3-(4-dimethylamino-pheny...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341811((1S,2R,3R)-2,3-Dimethyl-1-(8-fluoro-1,2,3,4-tetrah...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008596(CHEMBL154368 | Sodium; 4-[2-mercaptomethyl-3-(4-ni...)
Affinity DataIC50:  14nMAssay Description:The compound was tested in vitro for its inhibitory activity against Enkephalinase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341819((1S,2R,3R)-1-(6-Chloro-4H-thieno[3,2-b]indole-2-su...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341815((1S,2R,3R)-1-[(R)-4-(5-Difluoromethylisoxazol-3-yl...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008621(CHEMBL422339 | Sodium; 2-[2-mercaptomethyl-3-(4-ni...)
Affinity DataIC50:  17nMAssay Description:The compound was tested in vitro for its inhibitory activity against Enkephalinase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341808((1S,2R,3R)-1-(8-Fluoro-1,2,3,4-tetrahydropyrido[3'...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341816((1S,2R,3R)-1-[5-(4-Methoxypyrazol-1-yl)thiophene-2...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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