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Found 166 with Last Name = 'miyake' and Initial = 'y'
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513317(CHEMBL4465620)
Affinity DataKi:  68nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513318(CHEMBL4516553)
Affinity DataKi:  470nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272062((2S,5S)-1-((S)-3-mercapto-2-methylpropanoyl)-5-(3-...)
Affinity DataIC50:  0.0290nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272061((2S,5S)-1-((S)-3-mercapto-2-methylpropanoyl)-5-(ph...)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272145((2S,5S)-1-((S)-3-Mercapto-2-methyl-propionyl)-5-(3...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50532176(CHEMBL4542928)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human N-terminal FLAG/His-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-21)K4(Me3)-GGK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272199((2S,5S)-1-((S)-3-Mercapto-2-methyl-propionyl)-5-(2...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272060((2S,5S)-5-(benzylthio)-1-((S)-3-mercapto-2-methylp...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272099((2S,5S)-1-((S)-3-mercapto-2-methylpropanoyl)-5-(na...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272203((2S,5R)-5-(4-isopropylbenzylthio)-1-((S)-3-mercapt...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272200((2S,5S)-5-(4-(methylthio)benzylthio)-1-((S)-3-merc...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272141((2S,5S)-1-((S)-3-mercapto-2-methylpropanoyl)-5-(na...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50532176(CHEMBL4542928)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of human C-terminal FLAG-tagged KDM5A (1 to 1090 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-21)K4(Me3)-GGK(Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Friedrich Miescher Institute For Biomedical Research

LigandPNGBDBM197336(R-TSA)
Affinity DataIC50:  4.67nMAssay Description:. Enzymatic characterization (Km determinations, Supplementary Fig. 3C) of zebrafish HDAC6 proteins (CD1-CD2; CD1H193A-CD2; CD1CD2H574A; CD1H193A- CD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6 [25-831](Danio rerio (Zebrafish))
Friedrich Miescher Institute For Biomedical Research

LigandPNGBDBM197336(R-TSA)
Affinity DataIC50:  5.45nMAssay Description:. Enzymatic characterization (Km determinations, Supplementary Fig. 3C) of zebrafish HDAC6 proteins (CD1-CD2; CD1H193A-CD2; CD1CD2H574A; CD1H193A- CD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Friedrich Miescher Institute For Biomedical Research

LigandPNGBDBM197336(R-TSA)
Affinity DataIC50:  5.76nMAssay Description:. Enzymatic characterization (Km determinations, Supplementary Fig. 3C) of zebrafish HDAC6 proteins (CD1-CD2; CD1H193A-CD2; CD1CD2H574A; CD1H193A- CD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50532173(CHEMBL4536443)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of full-length human N-terminal FLAG/His-tagged KDM5C (2 to 1560 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50532176(CHEMBL4542928)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of full-length human N-terminal FLAG/His-tagged KDM5C (2 to 1560 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Friedrich Miescher Institute For Biomedical Research

LigandPNGBDBM197336(R-TSA)
Affinity DataIC50:  8.09nMAssay Description:. Enzymatic characterization (Km determinations, Supplementary Fig. 3C) of zebrafish HDAC6 proteins (CD1-CD2; CD1H193A-CD2; CD1CD2H574A; CD1H193A- CD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272142((2S,5S)-5-(4-isopropylbenzylthio)-1-((S)-3-mercapt...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6 [25-831](Danio rerio (Zebrafish))
Friedrich Miescher Institute For Biomedical Research

LigandPNGBDBM197337(S-TSA)
Affinity DataIC50:  9.88nMAssay Description:. Enzymatic characterization (Km determinations, Supplementary Fig. 3C) of zebrafish HDAC6 proteins (CD1-CD2; CD1H193A-CD2; CD1CD2H574A; CD1H193A- CD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Friedrich Miescher Institute For Biomedical Research

LigandPNGBDBM197337(S-TSA)
Affinity DataIC50:  11.1nMAssay Description:. Enzymatic characterization (Km determinations, Supplementary Fig. 3C) of zebrafish HDAC6 proteins (CD1-CD2; CD1H193A-CD2; CD1CD2H574A; CD1H193A- CD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266136((R)-3-(4-iodobenzylthio)-2-((S)-3-mercapto-2-methy...)
Affinity DataIC50:  15nMAssay Description:Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272144((2S,5S)-5-(3-(4-isopropylphenyl)propylthio)-1-((S)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Friedrich Miescher Institute For Biomedical Research

LigandPNGBDBM197336(R-TSA)
Affinity DataIC50:  17.8nMAssay Description:. Enzymatic characterization (Km determinations, Supplementary Fig. 3C) of zebrafish HDAC6 proteins (CD1-CD2; CD1H193A-CD2; CD1CD2H574A; CD1H193A- CD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272143((2S,5S)-5-(4-isopropylphenethylthio)-1-((S)-3-merc...)
Affinity DataIC50:  19nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266170((R)-3-(4-ethylbenzylthio)-2-((S)-3-mercapto-2-meth...)
Affinity DataIC50:  21nMAssay Description:Inhibition of angiotensin-converting enzyme (unknown origin) in whole blood by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50532173(CHEMBL4536443)
Affinity DataIC50:  23nMAssay Description:Inhibition of human C-terminal FLAG-tagged KDM5A (1 to 1090 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-21)K4(Me3)-GGK(Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50:  23nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266173((R)-3-(4-tert-butylbenzylthio)-2-((S)-3-mercapto-2...)
Affinity DataIC50:  24nMAssay Description:Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Friedrich Miescher Institute For Biomedical Research

LigandPNGBDBM197336(R-TSA)
Affinity DataIC50:  29.2nMAssay Description:. Enzymatic characterization (Km determinations, Supplementary Fig. 3C) of zebrafish HDAC6 proteins (CD1-CD2; CD1H193A-CD2; CD1CD2H574A; CD1H193A- CD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272201((2S,5S)-5-(4-tert-butylbenzylthio)-1-((S)-3-mercap...)
Affinity DataIC50:  31nMAssay Description:Inhibition of guinea pig lung leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272202((2S,5S)-5-(4-cyclohexylbenzylthio)-1-((S)-3-mercap...)
Affinity DataIC50:  34nMAssay Description:Inhibition of guinea pig lung leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266075((R)-3-(benzylthio)-2-((S)-3-mercapto-2-methylpropa...)
Affinity DataIC50:  34nMAssay Description:Inhibition of angiotensin-converting enzyme (unknown origin) in whole blood by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266244((R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-(m...)
Affinity DataIC50:  46nMAssay Description:Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50532173(CHEMBL4536443)
Affinity DataIC50:  51nMAssay Description:Inhibition of human N-terminal FLAG/His-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-21)K4(Me3)-GGK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272142((2S,5S)-5-(4-isopropylbenzylthio)-1-((S)-3-mercapt...)
Affinity DataIC50:  52nMAssay Description:Inhibition of guinea pig lung leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266247((2R)-3-(1-(4-isopropylphenyl)ethylthio)-2-((S)-3-m...)
Affinity DataIC50:  55nMAssay Description:Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266316((R)-3-(2-(4-cyclohexylphenyl)propan-2-ylthio)-2-((...)
Affinity DataIC50:  55nMAssay Description:Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50532175(CHEMBL4436444)
Affinity DataIC50:  65nMAssay Description:Inhibition of human C-terminal FLAG-tagged KDM5A (1 to 1090 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-21)K4(Me3)-GGK(Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266248((2R)-3-(1-(4-isopropylphenyl)propylthio)-2-((S)-3-...)
Affinity DataIC50:  67nMAssay Description:Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266171((R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-pr...)
Affinity DataIC50:  72nMAssay Description:Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266175((R)-3-(4-cyclohexylbenzylthio)-2-((S)-3-mercapto-2...)
Affinity DataIC50:  79nMAssay Description:Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266280((R)-3-(2-(4-isopropylphenyl)propan-2-ylthio)-2-((S...)
Affinity DataIC50:  79nMAssay Description:Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266279((2R)-3-((4-isopropylphenyl)(phenyl)methylthio)-2-(...)
Affinity DataIC50:  91nMAssay Description:Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266133((R)-3-(4-fluorobenzylthio)-2-((S)-3-mercapto-2-met...)
Affinity DataIC50:  100nMAssay Description:Inhibition of angiotensin-converting enzyme (unknown origin) in whole blood by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266208((R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-me...)
Affinity DataIC50:  100nMAssay Description:Inhibition of angiotensin-converting enzyme (unknown origin) in whole blood by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Cavia porcellus)
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50272200((2S,5S)-5-(4-(methylthio)benzylthio)-1-((S)-3-merc...)
Affinity DataIC50:  120nMAssay Description:Inhibition of guinea pig lung leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266173((R)-3-(4-tert-butylbenzylthio)-2-((S)-3-mercapto-2...)
Affinity DataIC50:  130nMAssay Description:Inhibition of angiotensin-converting enzyme (unknown origin) in whole blood by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Santen Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50266136((R)-3-(4-iodobenzylthio)-2-((S)-3-mercapto-2-methy...)
Affinity DataIC50:  140nMAssay Description:Inhibition of angiotensin-converting enzyme (unknown origin) in whole blood by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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