BindingDB PrimarySearch_ki

Found 218 with Last Name = 'mone' and Initial = 'm'

Peroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Istituto Tumori&Quot;Giovanni Paolo Ii&Quot

Curated by ChEMBL

PNG

BDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)

Ki: 74nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

ChEBI
CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Peroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Istituto Tumori&Quot;Giovanni Paolo Ii&Quot

Curated by ChEMBL

PNG

BDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)

Ki: 88nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

MMDB PC cid PC sid PDB Similars

Details Article PubMed MMDB
PDB

3D Structure (crystal)

Integrase(Human immunodeficiency virus 1)
University Of Newcastle

Curated by ChEMBL

PNG

BDBM50595032(CHEMBL5178418)

Ki: 130nMAssay Description:Binding affinity to influenza A/Beijing/262/95 H1N1 neuraminidase expressed in baculovirus expression system using sialyl-lactose as substrateMore data for this Ligand-Target Pair

PDB MMDB
UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar

Integrase(Human immunodeficiency virus 1)
University Of Newcastle

Curated by ChEMBL

PNG

BDBM50595031(CHEMBL5199902)

Ki: 280nMAssay Description:Binding affinity to influenza A/Beijing/262/95 H1N1 neuraminidase expressed in baculovirus expression system using sialyl-lactose as substrateMore data for this Ligand-Target Pair

PDB MMDB
UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar

M-phase inducer phosphatase 3(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504063(CHEMBL4570006)

Ki: 400nMAssay Description:Inhibition of N-terminal His6-tagged human CDC25C (280 to 454 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate by doub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 1(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504063(CHEMBL4570006)

Ki: 600nMAssay Description:Inhibition of N-terminal His6-tagged human CDC25A (336 to 508 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate by doub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 1(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504077(CHEMBL4442406)

Ki: 600nMAssay Description:Inhibition of N-terminal His6-tagged human CDC25A (336 to 508 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate by doub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504064(CHEMBL4438316)

Ki: 800nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Peroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Istituto Tumori&Quot;Giovanni Paolo Ii&Quot

Curated by ChEMBL

PNG

BDBM28763((2S)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)

Ki: 971nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase MMDB PC cid PC sid PDB Similars

Details Article PubMed MMDB
PDB

3D Structure (crystal)

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504065(CHEMBL4438470)

Ki: 1.40E+3nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 3(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504074(CHEMBL4447602)

Ki: 1.90E+3nMAssay Description:Inhibition of N-terminal His6-tagged human CDC25C (280 to 454 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate by doub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase PC cid PC sid

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M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504087(CHEMBL4587130)

Ki: 2.70E+3nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504063(CHEMBL4570006)

Ki: 2.80E+3nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Integrase(Human immunodeficiency virus 1)
University Of Newcastle

Curated by ChEMBL

PNG

BDBM50300129(CHEMBL572528 | CIBACRON BLUE | Cibacron Blue 3Ga)

Ki: 2.90E+3nMAssay Description:Binding affinity to influenza A/Beijing/262/95 H1N1 neuraminidase expressed in baculovirus expression system using sialyl-lactose as substrateMore data for this Ligand-Target Pair

PDB MMDB
UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar

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M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504067(CHEMBL4437577)

Ki: 2.90E+3nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 1(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504074(CHEMBL4447602)

Ki: 3.00E+3nMAssay Description:Inhibition of N-terminal His6-tagged human CDC25A (336 to 508 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate by doub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase PC cid PC sid

Details Article PubMed

M-phase inducer phosphatase 3(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504077(CHEMBL4442406)

Ki: 4.00E+3nMAssay Description:Inhibition of N-terminal His6-tagged human CDC25C (280 to 454 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate by doub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504080(CHEMBL4525255)

Ki: 4.90E+3nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504081(CHEMBL4442999)

Ki: 5.10E+3nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM26617(4-[(2-carboxyphenyl)carbonyl]benzene-1,2-dicarboxy...)

Ki: 5.30E+3nMAssay Description:Competitive reversible inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OM...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504068(CHEMBL4465468)

Ki: 5.80E+3nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504075(CHEMBL4521134)

Ki: 6.10E+3nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504085(CHEMBL4585545)

Ki: 6.40E+3nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504088(CHEMBL4434749)

Ki: 6.50E+3nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504070(CHEMBL4473428)

Ki: 6.90E+3nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504071(CHEMBL4470428)

Ki: 7.10E+3nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504086(CHEMBL4520431)

Ki: 7.30E+3nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504066(CHEMBL4566865)

Ki: 7.40E+3nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504074(CHEMBL4447602)

Ki: 8.50E+3nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504079(CHEMBL4464552)

Ki: 9.90E+3nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504089(CHEMBL4449432)

Ki: 1.19E+4nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504078(CHEMBL4551836)

Ki: 1.25E+4nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504060(CHEMBL4592345)

Ki: 1.34E+4nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504069(CHEMBL4552533)

Ki: 1.69E+4nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504084(CHEMBL4443206)

Ki: 2.20E+4nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504072(CHEMBL4561981)

Ki: 3.00E+4nMAssay Description:Mixed inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate b...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504083(CHEBI:34876 | CHEMBL170408)

Ki: 3.20E+4nMAssay Description:Mixed inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate b...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504082(CHEMBL4437090)

Ki: 3.40E+4nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504073(CHEMBL4472907)

Ki: 3.60E+4nMAssay Description:Mixed inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate b...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504059(CHEMBL4465589)

Ki: 3.60E+4nMAssay Description:Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504062(CHEMBL4439019)

Ki: 4.50E+4nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504061(CHEMBL4452849)

Ki: 5.40E+4nMAssay Description:Mixed inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate b...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM50504076(CHEMBL4543585)

Ki: 5.50E+4nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

M-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL

PNG

BDBM52026(2-(1-naphthoyl)benzoic acid | 2-(naphthalene-1-car...)

Ki: 6.90E+4nMAssay Description:Mixed inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate b...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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S-adenosylmethionine decarboxylase proenzyme(Rattus norvegicus)
TBA

Curated by ChEMBL

PNG

BDBM50366974(CHEMBL1204407 | CHEMBL3392141)

Ki: 1.10E+5nMAssay Description:Tested for inhibition against S-adenosyl-L-methionine decarboxylase from rat liverMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

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S-adenosylmethionine decarboxylase proenzyme(Rattus norvegicus)
TBA

Curated by ChEMBL

PNG

BDBM50366972(CHEMBL3392188 | CHEMBL541665)

Ki: 1.20E+5nMAssay Description:Tested for inhibition against S-adenosyl-L-methionine decarboxylase from rat liverMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

S-adenosylmethionine decarboxylase proenzyme(Rattus norvegicus)
TBA

Curated by ChEMBL

PNG

BDBM50366973(CHEMBL3392182 | CHEMBL539876)

Ki: 1.80E+5nMAssay Description:Tested for inhibition against S-adenosyl-L-methionine decarboxylase from rat liverMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM11694((2S)-1-[(2S)-2-amino-2-cyclohexylacetyl]pyrrolidin...)

IC50: 2nMAssay Description:In vitro inhibitory activity against Dipeptidyl peptidase IV (DPP-IV) extracted from Caco-2 cellsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dipeptidyl peptidase 4(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

PNG

BDBM11694((2S)-1-[(2S)-2-amino-2-cyclohexylacetyl]pyrrolidin...)

IC50: 2.80nMAssay Description:In vitro inhibitory activity against Dipeptidyl peptidase IV (DPP-IV) extracted from rat plasmaMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM11694((2S)-1-[(2S)-2-amino-2-cyclohexylacetyl]pyrrolidin...)

IC50: 3.20nMAssay Description:In vitro inhibitory activity against Dipeptidyl peptidase IV (DPP-IV) extracted from human plasmaMore data for this Ligand-Target Pair

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Targets 31▿
- 2-Hydroxyacid oxidase 2 41
- Angiopoietin-1 receptor 33
- M-phase inducer phosphatase 2 32
- Peroxisome proliferator-activated receptor gamma 19
- ATP-dependent translocase ABCB1 16
- Dipeptidyl peptidase 4 12
- Peroxisome proliferator-activated receptor alpha 8
- Integrin alpha-IIb/beta-3 7
- Integrase 6
- Peroxisome proliferator-activated receptor delta 5
- Integrin alpha-5/beta-1 5
- Integrin alpha-V/beta-3 5
- Integrin alpha-V/beta-5 5
- S-adenosylmethionine decarboxylase proenzyme 3
- M-phase inducer phosphatase 1 3
- M-phase inducer phosphatase 3 3
- Receptor-type tyrosine-protein kinase FLT3 1
- TGF-beta receptor type-1 1
- Tyrosine-protein kinase ABL1 1
- Protein kinase C beta type 1
- Insulin-like growth factor 1 receptor 1
- Macrophage colony-stimulating factor 1 receptor 1
- Platelet-derived growth factor receptor alpha 1
- RAC-alpha serine/threonine-protein kinase 1
- Cyclin-dependent kinase 2 1
- Mast/stem cell growth factor receptor Kit 1
- Hepatocyte growth factor receptor 1
- Platelet-derived growth factor receptor beta 1
- Vascular endothelial growth factor receptor 2 1
- Insulin receptor 1
- Fibroblast growth factor receptor 1 1
- ...
Publications 10▿
- Bioorg Med Chem Lett 22: 4341-7 (2012) 41
- J Med Chem 62: 7089-7110 (2019) 38
- Bioorg Med Chem Lett 17: 5514-7 (2007) 37
- J Med Chem 55: 37-54 (2012) 32
- J Med Chem 57: 5829-34 (2014) 22
- Bioorg Med Chem 16: 362-73 (2008) 16
- J Med Chem 45: 2362-5 (2002) 12
- Bioorg Med Chem Lett 17: 4756-60 (2007) 11
- Eur J Med Chem 235: (2022) 6
- J Med Chem 23: 121-7 (1980) 3
Institutions 8▿
- Glaxosmithkline 48
- Advinus Therapeutics 41
- University Of Naples Federico Ii 38
- Istituto Tumori&Quot;Giovanni Paolo Ii&Quot 32
- Philipps-Universit£T Marburg 22
- Universit£ 16
- TBA 15
- University Of Newcastle 6
Affinity: 2 to 1.5E+6 nM▿
- Ki 47
- IC50 126
- Kd 7
- EC50 38
- Affinity ≤ nM
Xtal structures: 8
Docked structures: 0
Catalog Cmpds: 23