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Found 164 with Last Name = 'muranaka' and Initial = 'h'
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50051232(8-(4-Fluoro-benzyl)-2-furan-2-yl-8H-pyrazolo[4,3-e...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to rat A2A adenosine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273137((3-{[(3-Carbamimidoyl-phenyl)-({4-[1-(1-imino-ethy...)
Affinity DataKi:  1.73nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273136(CHEMBL455932 | CHEMBL463179 | {4-[2-(5-Carbamimido...)
Affinity DataKi:  5nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM21190(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Affinity DataKi:  5.30nMAssay Description:Displacement of MRS5346 from C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pich...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273299(CHEMBL455933 | {4-[2-(5-Carbamimidoyl-2-hydroxy-be...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273297(CHEMBL459136 | N-{2-[2-(5-Carbamimidoyl-2-hydroxy-...)
Affinity DataKi:  9.70nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50051226(7-(4-Fluoro-benzyl)-2-furan-2-yl-7H-pyrazolo[4,3-e...)
Affinity DataKi:  12nMAssay Description:Binding affinity to rat A2A adenosine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273229(CHEMBL455916 | {(5-Carbamimidoyl-2-hydroxy-benzene...)
Affinity DataKi:  14nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273188(3-[2-(4-tert-Butyl-phenyl)-ethylsulfamoyl]-4-hydro...)
Affinity DataKi:  27nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273138(4-Hydroxy-3-[2-(4-isopropyl-phenyl)-ethylsulfamoyl...)
Affinity DataKi:  29nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254384(CHEMBL4079067)
Affinity DataKi:  40nMAssay Description:Displacement of MRS5346 from C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pich...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM17283((2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S...)
Affinity DataKi:  41nMAssay Description:Inhibition of factor 10a in human plasmaMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50207816(CHEMBL273094 | N-(2-Amino-ethyl)-2-[4-(2,6-dioxo-1...)
Affinity DataKi:  50nMAssay Description:Displacement of MRS5346 from C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pich...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273262(CHEMBL458067 | {2-[2-(5-Carbamimidoyl-2-hydroxy-be...)
Affinity DataKi:  51nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273227(4-Hydroxy-3-{[2-(4-isopropyl-phenyl)-ethyl]-methyl...)
Affinity DataKi:  59nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273265(CHEMBL457633 | {2-[2-(5-Carbamimidoyl-2-hydroxy-be...)
Affinity DataKi:  62nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273187(4-Hydroxy-3-[2-(4-isopropoxy-phenyl)-ethylsulfamoy...)
Affinity DataKi:  100nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  481nMAssay Description:Displacement of MRS5346 from C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pich...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273136(CHEMBL455932 | CHEMBL463179 | {4-[2-(5-Carbamimido...)
Affinity DataKi:  500nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254363(CHEMBL4103324)
Affinity DataKi:  1.52E+3nMAssay Description:Displacement of MRS5346 from C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pich...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273189(3-[2-(4-Isopropyl-phenyl)-ethylsulfamoyl]-benzamid...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273190(4-Chloro-3-[2-(4-isopropyl-phenyl)-ethylsulfamoyl]...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273264(CHEMBL457632 | ethyl 2-(2-(2-(2-hydroxy-5-(N'-hydr...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273231(CHEMBL455919 | ethyl 2-(N-(4-isopropylphenethyl)-2...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273230(CHEMBL509493 | {[2-Hydroxy-5-(N-hydroxycarbamimido...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273228(4,N-Dihydroxy-3-[2-(4-isopropyl-phenyl)-ethylsulfa...)
Affinity DataKi:  7.30E+3nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273187(4-Hydroxy-3-[2-(4-isopropoxy-phenyl)-ethylsulfamoy...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human thrombin by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273189(3-[2-(4-Isopropyl-phenyl)-ethylsulfamoyl]-benzamid...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human thrombin by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273138(4-Hydroxy-3-[2-(4-isopropyl-phenyl)-ethylsulfamoyl...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human thrombin by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273263(2-(2-(2-(2-hydroxy-5-(N'-hydroxycarbamimidoyl)phen...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273191(3-[2-(4-Isopropyl-phenyl)-ethylsulfamoyl]-4-methox...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273137((3-{[(3-Carbamimidoyl-phenyl)-({4-[1-(1-imino-ethy...)
Affinity DataKi:  2.60E+4nMAssay Description:Inhibition of human thrombin by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273136(CHEMBL455932 | CHEMBL463179 | {4-[2-(5-Carbamimido...)
Affinity DataKi:  5.78E+4nMAssay Description:Inhibition of human thrombin by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM17283((2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S...)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Canis familiaris)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  0.100nMAssay Description:Agonistic activity for Beta-2 adrenergic receptor was assessed by it's inhibitory effect on spontaneous contractions in isolated rat uterusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Rattus norvegicus)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of spontaneous contractions in isolated rat uterusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Canis familiaris)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  0.100nMAssay Description:Agonistic activity towards beta-2 adrenoceptor. IC50, the mean concentration required to produce 50% inhibition of uterine contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  0.930nMAssay Description:Inhibition of wild type human N-terminal GST-fusion tagged TRKB kinase domain (456 to 822 residues) expressed in baculovirus expression system by HTR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of wild type human His-tagged TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system by HTRF assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of juxtamembrane region deficient recombinant human N-terminal His6-tagged/GST-tagged TrkA (498 to 796 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of TRKA E735A mutant (unknown origin) expressed in baculovirus infected sf9 cells assessed as kinase domain dimerization by HTRF assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of juxtamembrane region containing recombinant human N-terminal His6-tagged/GST-tagged TrkA (473 to 796 residues) expressed in baculovirus...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50:  6nMAssay Description:Inhibition of juxtamembrane region containing recombinant human N-terminal His6-tagged/GST-tagged TrkA (473 to 796 residues) expressed in baculovirus...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of recombinant human TrkB expressed in DHFR deficient CHO cells assessed as inhibition of human brain-derived neurotrophic factor-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of recombinant human TrkC expressed in DHFR deficient CHO cells assessed as inhibition of human neurotrophin-3-induced calcium influx by F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of juxtamembrane region deficient recombinant human N-terminal His6-tagged/GST-tagged TrkA (498 to 796 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Canis familiaris)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50002133((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Affinity DataIC50:  9.10nMAssay Description:Agonistic activity for Beta-2 adrenergic receptor was assessed by it's inhibitory effect on spontaneous contractions in isolated rat uterusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Rattus norvegicus)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50002133((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of spontaneous contractions in isolated rat uterusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Rattus norvegicus)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50002133((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Affinity DataIC50:  9.12nMAssay Description:Agonistic activity towards beta-2 adrenoceptor. Mean concentration required to produce 50% inhibition of uterine contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of recombinant human TrkA expressed in DHFR deficient CHO cells assessed as inhibition of human beta-nerve growth factor-induced calcium i...More data for this Ligand-Target Pair
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