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Found 117 with Last Name = 'naito' and Initial = 'm'
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Novartis Takarazuka Research Institute

Curated by ChEMBL
LigandPNGBDBM50390978(VALSPODAR)
Affinity DataKi:  134nMAssay Description:TP_TRANSPORTER: inhibition of ATPase activity (Verapamil) in P-gp-MRP-16-Protein A complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50171495(CHEMBL3805318)
Affinity DataIC50:  0.0900nMAssay Description:Antagonist activity at ERalpha (unknown origin) transfected in 17beta-estradiol induced-HEK293 cells assessed as inhibition of estradiol-mediated pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.470nMAssay Description:Displacement of Fluormone ES2 from human recombinant full length untagged-ERalpha by fluorescence polarization competition binding assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50171494(CHEMBL3806167)
Affinity DataIC50:  0.680nMAssay Description:Antagonist activity at ERalpha (unknown origin) transfected in 17beta-estradiol induced-HEK293 cells assessed as inhibition of estradiol-mediated pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of estrogen receptor alpha (unknown origin)-SRC1 coactivator interaction incubated for 1 hr by receptor cofactor assay system based methodMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459869(CHEMBL4227715)
Affinity DataIC50:  1.40nMAssay Description:Binding affinity to androgen receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459874(CHEMBL4226259)
Affinity DataIC50:  1.40nMAssay Description:Binding affinity to androgen receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50171499(CHEMBL3805385)
Affinity DataIC50:  1.80nMAssay Description:Displacement of Fluormone ES2 from human recombinant full length untagged-ERalpha by fluorescence polarization competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50092526(CHEMBL3586195)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of ERalpha (unknown origin) by fluorescence polarization-based competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50092484(CHEMBL3586191)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of ERalpha (unknown origin) by fluorescence polarization-based competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50092523(CHEMBL3586193)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of ERalpha (unknown origin) by fluorescence polarization-based competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50279272(CHEMBL4164385)
Affinity DataIC50:  4.80nMAssay Description:Concentration required to protect the cell against HIV-1 strain IIIB viral cytopathogenicity by 50% in MT-4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50437046(CHEMBL2403356)
Affinity DataIC50:  4.90nMAssay Description:Antagonist activity at ERalpha (unknown origin) expressed in human MCF7 cells assessed as inhibition of E2-induced response by dual luciferase report...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of ERalpha (unknown origin) by fluorescence polarization-based competition binding assayMore data for this Ligand-Target Pair
TargetBaculoviral IAP repeat-containing protein 3(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50279272(CHEMBL4164385)
Affinity DataIC50:  5.70nMAssay Description:Inhibitory concentration against SO561945 (HIV 1 mutant RT) viral viral infection of MT-4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50171495(CHEMBL3805318)
Affinity DataIC50:  5.90nMAssay Description:Displacement of Fluormone ES2 from human recombinant full length untagged-ERalpha by fluorescence polarization competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50437046(CHEMBL2403356)
Affinity DataIC50:  7.30nMAssay Description:Displacement of Fluormone ES2 from full length recombinant human untagged ERalpha expressed in Sf insect cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50171498(CHEMBL3805025)
Affinity DataIC50:  11nMAssay Description:Displacement of Fluormone ES2 from human recombinant full length untagged-ERalpha by fluorescence polarization competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50092522(CHEMBL3586192)
Affinity DataIC50:  11nMAssay Description:Inhibition of ERalpha (unknown origin) by fluorescence polarization-based competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50104834(CHEMBL3597499)
Affinity DataIC50:  13nMAssay Description:Inhibition of estrogen receptor alpha (unknown origin)-SRC1 coactivator interaction incubated for 1 hr by receptor cofactor assay system based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50092501(CHEMBL3098274)
Affinity DataIC50:  14nMAssay Description:Inhibition of ERalpha (unknown origin) by fluorescence polarization-based competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50550011(CHEMBL4747168)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant human HPGDSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459873(CHEMBL4225186)
Affinity DataIC50:  27nMAssay Description:Displacement of [17-alpha-methyl-H-3] mibolerone from wild-type androgen receptor (unknown origin) expressed in human Freestyle293F cells measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50171497(CHEMBL3804907)
Affinity DataIC50:  28nMAssay Description:Displacement of Fluormone ES2 from human recombinant full length untagged-ERalpha by fluorescence polarization competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50279265(CHEMBL4162041)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant human His-tagged full length ABL1 allosteric site expressed in baculovirus expression system by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50104835(CHEMBL3597498)
Affinity DataIC50:  35nMAssay Description:Inhibition of estrogen receptor alpha (unknown origin)-SRC1 coactivator interaction incubated for 1 hr by receptor cofactor assay system based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50171494(CHEMBL3806167)
Affinity DataIC50:  40nMAssay Description:Displacement of Fluormone ES2 from human recombinant full length untagged-ERalpha by fluorescence polarization competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50171493(CHEMBL3805170)
Affinity DataIC50:  49nMAssay Description:Displacement of Fluormone ES2 from human recombinant full length untagged-ERalpha by fluorescence polarization competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50092483(CHEMBL3586190)
Affinity DataIC50:  53nMAssay Description:Inhibition of ERalpha (unknown origin) by fluorescence polarization-based competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459875(CHEMBL4226844)
Affinity DataIC50:  53nMAssay Description:Binding affinity to androgen receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459868(CHEMBL4225339)
Affinity DataIC50:  54nMAssay Description:Binding affinity to androgen receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50171492(CHEMBL3805921)
Affinity DataIC50:  61nMAssay Description:Displacement of Fluormone ES2 from human recombinant full length untagged-ERalpha by fluorescence polarization competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50279272(CHEMBL4164385)
Affinity DataIC50:  67nMAssay Description:Inhibition of recombinant human His-tagged XIAP (Asn252 to Thr356 residues) expressed in Escherichia coli by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50:  71nMAssay Description:Inhibition of recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 3 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50591607(CHEMBL5193611)
Affinity DataIC50:  78nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50:  83nMAssay Description:Inhibition of recombinant human HPGDS using [14C]-PGH2 as substrate preincubated for 1 min in presence of MgCl2 followed by substrate addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50279273(CHEMBL4160980)
Affinity DataIC50:  86nMAssay Description:Concentration required to protect the cell against HIV-1 strain IIIB viral cytopathogenicity by 50% in MT-4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50104800(CHEMBL3597509)
Affinity DataIC50:  94nMAssay Description:Inhibition of estrogen receptor alpha (unknown origin)-SRC1 coactivator interaction incubated for 1 hr by receptor cofactor assay system based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50279274(CHEMBL4172268)
Affinity DataIC50:  94nMAssay Description:Concentration required to protect the cell against HIV-1 strain IIIB viral cytopathogenicity by 50% in MT-4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50104804(CHEMBL3597505)
Affinity DataIC50:  110nMAssay Description:Inhibition of estrogen receptor alpha (unknown origin)-SRC1 coactivator interaction incubated for 1 hr by receptor cofactor assay system based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50587270(CHEMBL5076100)
Affinity DataIC50:  117nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50279273(CHEMBL4160980)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant human His-tagged XIAP (Asn252 to Thr356 residues) expressed in Escherichia coli by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50591608(CHEMBL5207946)
Affinity DataIC50:  124nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM136516(US8865714, 3)
Affinity DataIC50:  134nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50587271(CHEMBL5075403)
Affinity DataIC50:  140nMAssay Description:Inhibition of H-PGDS (unknown origin) using fluorescent probe by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 3(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50279273(CHEMBL4160980)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant human His-tagged cIAP2 (Gln238 to Ser349 residues) expressed in Escherichia coli by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50092482(CHEMBL3098273)
Affinity DataIC50:  151nMAssay Description:Inhibition of ERalpha (unknown origin) by fluorescence polarization-based competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50587270(CHEMBL5076100)
Affinity DataIC50:  170nMAssay Description:Inhibition of H-PGDS (unknown origin) using fluorescent probe by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50:  170nMAssay Description:Inhibition of H-PGDS (unknown origin) using fluorescent probe by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459866(CHEMBL4226899)
Affinity DataIC50:  190nMAssay Description:Displacement of [17-alpha-methyl-H-3] mibolerone from wild-type androgen receptor (unknown origin) expressed in human Freestyle293F cells measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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