Found 9 Enz. Inhib. hit(s) with Target = 'ATP-dependent translocase ABCB1' and Ligand = 'BDBM50390978' TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Novartis Takarazuka Research Institute
Curated by ChEMBL
Novartis Takarazuka Research Institute
Curated by ChEMBL
Affinity DataKi: 134nMAssay Description:TP_TRANSPORTER: inhibition of ATPase activity (Verapamil) in P-gp-MRP-16-Protein A complexMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Novartis Takarazuka Research Institute
Curated by ChEMBL
Novartis Takarazuka Research Institute
Curated by ChEMBL
Affinity DataKi: 1.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in CEM/VBL 100 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Novartis Takarazuka Research Institute
Curated by ChEMBL
Novartis Takarazuka Research Institute
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Novartis Takarazuka Research Institute
Curated by ChEMBL
Novartis Takarazuka Research Institute
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Novartis Takarazuka Research Institute
Curated by ChEMBL
Novartis Takarazuka Research Institute
Curated by ChEMBL
Affinity DataIC50: 291nMAssay Description:TP_TRANSPORTER: inhibition of Doxorubicin transepithelial transport (basal to apical) (Doxorubicin: 0.8 uM) in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Novartis Takarazuka Research Institute
Curated by ChEMBL
Novartis Takarazuka Research Institute
Curated by ChEMBL
Affinity DataIC50: 501nMAssay Description:Inhibition of P-glycoprotein-mediated daunorubicin efflux from human CCRF-CEM/VCR1000 cells after 240 secs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Novartis Takarazuka Research Institute
Curated by ChEMBL
Novartis Takarazuka Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.06E+3nMAssay Description:TP_TRANSPORTER: inhibition of Vinblastine transepithelial transport (basal to apical) (Vinblastine: 0.1 uM) in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Novartis Takarazuka Research Institute
Curated by ChEMBL
Novartis Takarazuka Research Institute
Curated by ChEMBL
Affinity DataEC50: 410nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.25 uM) in MDR-CEM cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Novartis Takarazuka Research Institute
Curated by ChEMBL
Novartis Takarazuka Research Institute
Curated by ChEMBL
Affinity DataEC50: 110nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.25 uM) in MDR-P388 cellsMore data for this Ligand-Target Pair
