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Found 78 with Last Name = 'napper' and Initial = 'ad'
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481568(CHEMBL592712)
Affinity DataKi:  62nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM51599(3-[3-[(5-ethyl-[1,2,4]triazin[5,6-b]indol-3-yl)thi...)
Affinity DataKi:  100nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM51395(CHEMBL263634 | N-[(2S)-1-[[[2-(3,4-dihydro-2H-quin...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50377081(CHEMBL258492)
Affinity DataIC50:  41nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50374666(CHEMBL259450)
Affinity DataIC50:  56nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178775((S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]in...)
Affinity DataIC50:  63nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  98nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  98nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50377080(CHEMBL259183)
Affinity DataIC50:  110nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50377083(CHEMBL259451)
Affinity DataIC50:  115nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481568(CHEMBL592712)
Affinity DataIC50:  120nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50:  124nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM51599(3-[3-[(5-ethyl-[1,2,4]triazin[5,6-b]indol-3-yl)thi...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50377079(CHEMBL406930)
Affinity DataIC50:  201nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178773(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50:  205nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM32784(2-thiophenecarboxylic acid [5-amino-1-(benzenesulf...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase/reductase(Mycobacterium tuberculosis)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM51599(3-[3-[(5-ethyl-[1,2,4]triazin[5,6-b]indol-3-yl)thi...)
Affinity DataIC50:  398nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC/RmlD expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481569(CHEMBL590576)
Affinity DataIC50:  400nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178787(7-chloro-1,2,3,4-tetrahydrocyclopenta[b]indole-3-c...)
Affinity DataIC50:  409nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM32783(2-thiophenecarboxylic acid [5-amino-1-(4-fluorophe...)
Affinity DataIC50:  440nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481561(CHEMBL592545)
Affinity DataIC50:  500nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50:  652nMAssay Description:Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM35509(2-thiophenecarboxylic acid [5-amino-1-(4-methoxyph...)
Affinity DataIC50:  690nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM32784(2-thiophenecarboxylic acid [5-amino-1-(benzenesulf...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human liver cathepsin B preincubated for 17 hrs in buffer without DTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481567(CHEMBL600648)
Affinity DataIC50:  800nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481565(CHEMBL592546)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM32756(2-furancarboxylic acid [5-amino-1-(4-fluorophenyl)...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM32784(2-thiophenecarboxylic acid [5-amino-1-(benzenesulf...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human liver cathepsin B preincubated for 2 hrs in buffer without DTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM32784(2-thiophenecarboxylic acid [5-amino-1-(benzenesulf...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human liver cathepsin B preincubated for 2 hrs in non-buffer solution without DTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM32665(2-furancarboxylic acid [5-amino-1-(4-methylphenyl)...)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM32784(2-thiophenecarboxylic acid [5-amino-1-(benzenesulf...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human liver cathepsin B preincubated for 17 hrs in non-buffer solution without DTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM32755(2-thiophenecarboxylic acid [5-amino-1-(4-methylphe...)
Affinity DataIC50:  1.99E+3nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178784(6-bromo-2,3,4,9-tetrahydro-1H-carbazole-2-carboxam...)
Affinity DataIC50:  2.44E+3nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178773(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178774(1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxamid...)
Affinity DataIC50:  2.67E+3nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50:  2.77E+3nMAssay Description:Inhibitory activity against recombinant human SIRT2 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481562(CHEMBL589357)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50377078(CHEMBL263661)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM32784(2-thiophenecarboxylic acid [5-amino-1-(benzenesulf...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human liver cathepsin B preincubated for 24 hrs in buffer without DTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481566(CHEMBL589358)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM32784(2-thiophenecarboxylic acid [5-amino-1-(benzenesulf...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human liver cathepsin B preincubated for 24 hrs in non-buffer solution without DTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM32784(2-thiophenecarboxylic acid [5-amino-1-(benzenesulf...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human liver cathepsin B preincubated for 2 hrs in assay buffer with DTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481563(CHEMBL600848)
Affinity DataIC50:  1.03E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178773(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibitory activity against recombinant human SIRT2 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178786(1,6-dimethyl-2,3,4,9-tetrahydro-1H-carbazole-1-car...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178772(6-hydroxy-2,3,4,9-tetrahydro-1H-carbazole-1-carbox...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178768(6-chloro-2,3,4,9-tetrahydro-1H-beta-carboline-1-ca...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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