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Found 134 with Last Name = 'novelli' and Initial = 'f'
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428369((+)-Anatoxin-A | CHEMBL2332144)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]nicotine from alpha4beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50219206(Anthracen-9-yl (10H-phenothiazine-10yl) methanone,...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human erythrocytes BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50219206(Anthracen-9-yl (10H-phenothiazine-10yl) methanone,...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human plasma BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428369((+)-Anatoxin-A | CHEMBL2332144)
Affinity DataKi:  91nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428368(CHEMBL2332145)
Affinity DataKi:  94nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  230nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR from rat hippocampusMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50143282((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)
Affinity DataKi:  230nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR from rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428372(CHEMBL2332152)
Affinity DataKi:  2.60E+4nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR from rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428371(CHEMBL2332153)
Affinity DataKi:  2.90E+4nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR from rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428370((+)-Laburnamine | CHEMBL2332146)
Affinity DataKi:  4.00E+4nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR from rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428368(CHEMBL2332145)
Affinity DataKi:  1.00E+5nMAssay Description:Displacement of [3H]methyllycaconitine from alpha7 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dipartimento Di Scienze Farmaceutiche - Università

Curated by ChEMBL
LigandPNGBDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Affinity DataIC50:  3.80nMAssay Description:Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human plasma BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human erythrocytes BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50312803((3aS,8aR)-3a,8-dimethyl-1-phenethyl-1,2,3,3a,8,8a-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human plasma BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50312803((3aS,8aR)-3a,8-dimethyl-1-phenethyl-1,2,3,3a,8,8a-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human erythrocytes BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dipartimento Di Scienze Farmaceutiche - Università

Curated by ChEMBL
LigandPNGBDBM50082336(CHEMBL322378 | N-(4-Benzoyl-2-methyl-phenyl)-2-(R)...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346444(CHEMBL1782707 | [4-(4-morpholinyl)butyl]carbamic a...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human plasma BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346444(CHEMBL1782707 | [4-(4-morpholinyl)butyl]carbamic a...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human erythrocytes BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dipartimento Di Scienze Farmaceutiche - Università

Curated by ChEMBL
LigandPNGBDBM50082333(11-[2-(Octahydro-quinolizin-1-ylmethylsulfanyl)-ac...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dipartimento Di Scienze Farmaceutiche - Università

Curated by ChEMBL
LigandPNGBDBM50082335(11-((S)-2-Octahydro-quinolizin-1-yl-thioacetyl)-5,...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human plasma AChEMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human erythrocytes AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human erythrocytes AChEMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(RAT)
Dipartimento Di Scienze Farmaceutiche - Università

Curated by ChEMBL
LigandPNGBDBM50082334(11-{2-[(Octahydro-quinolizin-1-ylmethyl)-amino]-ac...)
Affinity DataIC50:  28nMAssay Description:Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human erythrocytes BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human plasma BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMuscarinic acetylcholine receptor M1(RAT)
Dipartimento Di Scienze Farmaceutiche - Università

Curated by ChEMBL
LigandPNGBDBM50450970(CHEMBL2111621)
Affinity DataIC50:  40nMAssay Description:Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human erythrocytes BChEMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human plasma BChEMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(RAT)
Dipartimento Di Scienze Farmaceutiche - Università

Curated by ChEMBL
LigandPNGBDBM50450971(CHEMBL2112418)
Affinity DataIC50:  110nMAssay Description:Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346435((1S,9aR)-1-((9H-thioxanthen-9-yl)methyl)octahydro-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocoline iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human plasma AChEMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human erythrocytes AChEMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346417(6-chloro-2-methoxy-N-(3-(((1R,9aR)-octahydro-1H-qu...)
Affinity DataIC50:  220nMAssay Description:Inhibition of bovine erythrocyte AChE using acetylthiocholine iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346422(10-(3-(4-hydroxypiperidin-1-yl)propyl)-10H-phenoth...)
Affinity DataIC50:  230nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocoline iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8958(10-(2-diethylaminopropyl)phenothiazine | CHEMBL120...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human erythrocytes AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
Dipartimento Di Scienze Farmaceutiche - Università

Curated by ChEMBL
LigandPNGBDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Affinity DataIC50:  300nMAssay Description:Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8958(10-(2-diethylaminopropyl)phenothiazine | CHEMBL120...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human plasma BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8958(10-(2-diethylaminopropyl)phenothiazine | CHEMBL120...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human erythrocytes BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346416(6-chloro-2-methoxy-N-(2-(((1R,9aR)-octahydro-1H-qu...)
Affinity DataIC50:  340nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocoline iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346436(5-Methyl-1-(9H-thioxanthen-9-ylmethyl)-(1S,9aR)-oc...)
Affinity DataIC50:  410nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocoline iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346408(2-(((1R,9aR)-octahydro-1H-quinolizin-1-yl)methylth...)
Affinity DataIC50:  430nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocoline iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346410(2-[(1R,9aR)-(Octahydro-1H-quinolizin-1-yl)methylth...)
Affinity DataIC50:  470nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocoline iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346425((1S,9aR)-1-((10H-phenothiazin-10-yl)methyl)-5-meth...)
Affinity DataIC50:  510nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocoline iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346442((1S,9aR)-1-((9H-fluoren-9-yl)methyl)octahydro-1H-q...)
Affinity DataIC50:  630nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocoline iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dipartimento Di Scienze Farmaceutiche - Università

Curated by ChEMBL
LigandPNGBDBM50082338(11-(2-Octahydro-quinolizin-1-yl-acetyl)-6,11-dihyd...)
Affinity DataIC50:  650nMAssay Description:Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346421(6-(5-(((1R,9aR)-octahydro-1H-quinolizin-1-yl)methy...)
Affinity DataIC50:  680nMAssay Description:Inhibition of bovine erythrocyte AChE using acetylthiocholine iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dipartimento Di Scienze Farmaceutiche - Università

Curated by ChEMBL
LigandPNGBDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Affinity DataIC50:  690nMAssay Description:Displacement of [3H]-methylscopolamine binding to muscarinic M2 receptor in rat heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346417(6-chloro-2-methoxy-N-(3-(((1R,9aR)-octahydro-1H-qu...)
Affinity DataIC50:  690nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocoline iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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