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Found 482 with Last Name = 'peng' and Initial = 'z'
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222915(4'-[5-(4-pyrrolidin-1-ylmethyl-phenylamino)-1H-pyr...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222916(4'-{5-[4-(dimethylamino-methyl)-phenylamino]-2H-py...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222920(4'-{5-[6-(sec-butylamino-methyl)-pyridin-3-ylamino...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222917(4'-[5-(6-piperidin-1-ylmethyl-pyridin-3-ylamino)-1...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222914(4'-[5-(4-cyclopropylaminomethyl-phenylamino)-2H-py...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222921(3-(1H-benzo[d]imidazol-2-yl)-N-(2,4-dihydroxypheny...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222919(4'-(5-{6-[(cyclopropylmethyl-amino)-methyl]-pyridi...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222918(4'-(5-phenylamino-2H-pyrazol-3-yl)-biphenyl-2,4-di...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032651(1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-y...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344250(CHEMBL1779003 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL
LigandPNGBDBM50493380(CHEMBL2425469)
Affinity DataKi:  14nMAssay Description:Mixed-type competitive inhibition of Helicobacter pylori ATCC 43504 urease using urea as substrate by Lineweaver-burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344232(1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyra...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL
LigandPNGBDBM50493373(CHEMBL2425478)
Affinity DataKi:  45nMAssay Description:Mixed-type competitive inhibition of Helicobacter pylori ATCC 43504 urease using urea as substrate by Lineweaver-burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344251(CHEMBL1779004 | N-((4'-fluoro-2'-methoxybiphenyl-3...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344233(CHEMBL1778866 | N-((6-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  53nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344234(CHEMBL1778867 | N-((6-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344252(CHEMBL1779005 | N-((6-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344259(CHEMBL1779012 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  80nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344254(CHEMBL1779007 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  112nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344260(CHEMBL1779013 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  116nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344241(CHEMBL1778994 | N-((6-(2,3-difluorophenyl)pyrazin-...)
Affinity DataKi:  186nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344235(CHEMBL1778868 | N-((6-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  214nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344236(CHEMBL1778869 | N-((6-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  217nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344237(CHEMBL1778870 | N-((6-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  255nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344255(CHEMBL1779008 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  266nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344262(CHEMBL1779015 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  268nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222922(3-(1H-benzo[d]imidazol-2-yl)-N-(4-hydroxyphenyl)-1...)
Affinity DataKi:  301nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344264(CHEMBL1779016 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  340nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344242(1-cyclopropyl-N-((6-(2,3-difluorophenyl)pyrazin-2-...)
Affinity DataKi:  341nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344265(3-((5-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)methy...)
Affinity DataKi:  420nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344238(CHEMBL1778991 | N-((6-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  429nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344256(3-(4-fluoro-2-methoxyphenyl)-5-(pyrrolidin-2-yl)py...)
Affinity DataKi:  440nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344261(CHEMBL1779014 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  450nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344257(CHEMBL1779010 | N-benzyl-5-(4-fluoro-2-methoxyphen...)
Affinity DataKi:  457nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344266(CHEMBL1779018 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  468nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344267(CHEMBL1779019 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  595nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344244(1-cyclopropyl-N-((6-(2-fluoro-3-methoxyphenyl)pyra...)
Affinity DataKi:  602nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344239((S)-1-(6-(4-fluoro-2-methoxyphenyl)pyrazin-2-yl)-N...)
Affinity DataKi:  610nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL
LigandPNGBDBM50491169(CHEMBL2377164)
Affinity DataKi:  641nMAssay Description:Competitive inhibition of Helicobacter pylori ATCC 43504 urease using urea as substrate by Lineweaver-Burk/Dixon plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344258(5-(4-fluoro-2-methoxyphenyl)-N-(tetrahydro-2H-pyra...)
Affinity DataKi:  705nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344268(CHEMBL1779020 | ethyl 2-((5-(4-fluoro-2-methoxyphe...)
Affinity DataKi:  778nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344246(3-(6-((cyclopentylamino)methyl)pyrazin-2-yl)benzon...)
Affinity DataKi:  1.55E+3nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344247(4-(6-((cyclopentylamino)methyl)pyrazin-2-yl)benzon...)
Affinity DataKi:  1.57E+3nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344248(CHEMBL1779001 | N-((6-(2,4-dimethoxyphenyl)pyrazin...)
Affinity DataKi:  1.69E+3nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344243(CHEMBL1778996 | N-((6-(2,3-difluorophenyl)pyrazin-...)
Affinity DataKi:  2.98E+3nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344240(1-(6-(4-fluoro-2-methoxyphenyl)pyrazin-2-yl)-N-(py...)
Affinity DataKi:  3.57E+3nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344245(CHEMBL1778998 | N-((6-(2-fluoro-3-methoxyphenyl)py...)
Affinity DataKi:  5.70E+3nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344253(CHEMBL1779006 | N-((2-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  8.90E+3nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344249(CHEMBL1779002 | N-(3-(6-((cyclopentylamino)methyl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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