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Found 744 with Last Name = 'peterson' and Initial = 'd'
TargetGenome polyprotein(Hepatitis C virus)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50142916((1S,4R,6S,14S,18R)-14-Cyclopentyloxycarbonylamino-...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of HCV 1a NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50315914((3-(2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholin...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50315915(5-(7-methyl-6-(3-(methylsulfonyl)phenyl)-4-morphol...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50315911(5-(6-(3-(methylsulfonyl)phenyl)-4-morpholinothieno...)
Affinity DataKi:  5nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50315913((3-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50315908(CHEMBL1090598 | N-((2-(2-aminopyrimidin-5-yl)-4-mo...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)
Affinity DataKi:  21nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50312606(5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...)
Affinity DataKi:  29nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50315912(CHEMBL1091979 | N-((2-(2-aminopyrimidin-5-yl)-7-me...)
Affinity DataKi:  30nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50304689(5-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimid...)
Affinity DataKi:  42nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50315909(CHEMBL1090599 | N-((2-(2-aminopyrimidin-5-yl)-4-mo...)
Affinity DataKi:  50nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50315910(5-(6-(2-aminopropan-2-yl)-4-morpholinothieno[3,2-d...)
Affinity DataKi:  59nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKi:  570nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Src protein tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Brutons tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597908(CHEMBL5181496)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597908(CHEMBL5181496)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50315908(CHEMBL1090598 | N-((2-(2-aminopyrimidin-5-yl)-4-mo...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kalpha assessed as reduction in 3,4,5-inositoltriphosphate accumulation after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315913((3-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kalpha assessed as reduction in 3,4,5-inositoltriphosphate accumulation after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597906(CHEMBL5183539)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597915(CHEMBL5185237)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of LDHB (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597915(CHEMBL5185237)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of LDHB (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597916(CHEMBL5201115)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597916(CHEMBL5201115)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50312606(5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kalpha assessed as reduction in 3,4,5-inositoltriphosphate accumulation after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315914((3-(2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholin...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kalpha assessed as reduction in 3,4,5-inositoltriphosphate accumulation after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126751(2-(2,6-Dichloro-phenylamino)-7-(3-ethylamino-prope...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126739(2-(2,6-Dichloro-phenylamino)-1,6-dimethyl-7-(3-pyr...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126735(7-(3-Amino-propenyl)-2-(2,6-dichloro-phenylamino)-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Protein tyrosine kinase LynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597916(CHEMBL5201115)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of LDHB (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597896(CHEMBL5181996)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597896(CHEMBL5181996)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597916(CHEMBL5201115)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of LDHB (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597915(CHEMBL5185237)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597913(CHEMBL5194549)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597913(CHEMBL5194549)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597915(CHEMBL5185237)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597909(CHEMBL5196929)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597909(CHEMBL5196929)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597908(CHEMBL5181496)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of LDHB (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597908(CHEMBL5181496)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of LDHB (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597904(CHEMBL5176448)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597904(CHEMBL5176448)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597905(CHEMBL5182266)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50597905(CHEMBL5182266)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assayMore data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  3nMAssay Description:LDHA, LDHB, LDHC, MDH1 and MDH2 enzymatic assays have been described in detail previously [Dragovich, P.S. et al, Bioorg. Med. Chem. Lett. 24:3764-37...More data for this Ligand-Target Pair
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