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Found 477 with Last Name = 'qin' and Initial = 'z'
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553486(CHEMBL4782409)
Affinity DataKi:  1.70nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human CDK9 (M1 to F372 residues)/cyclin-T1 (M1 to K726 residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553486(CHEMBL4782409)
Affinity DataKi:  2.90nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human CDK6 (M1 to A326 residues)/cyclin D1 (Q4 to I295 residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553486(CHEMBL4782409)
Affinity DataKi:  4nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human CDK4 (S4 to E303 residues)/cyclin D1 (Q4 to I295 residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA
LigandPNGBDBM50589394(CHEMBL4797564)
Affinity DataIC50:  0.0960nMAssay Description:Inhibition of human CLK2 administered orallyMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207586(US10501467, Example 31 | US9260440, 31 | US9617273...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207583(US10501467, Example 28 | US9260440, 28 | US9617273...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207595(US10501467, Example 40 | US9260440, 40 | US9617273...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207588(US10501467, Example 33 | US9260440, 33 | US9617273...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553495(CHEMBL4786559)
Affinity DataIC50: <0.5nMAssay Description:Displacement of Alexa Fluor 647 ADP Tracer from His-tagged human CDK9/Cyclin T1 expressed in baculovirus expression system incubated for 1 hr by adap...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207570(US10501467, Example 15 | US9260440, 15 | US9617273...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))TBA
LigandPNGBDBM50589394(CHEMBL4797564)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of human CLK4 administered orallyMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207563(US10501467, Example 8 | US9260440, 8 | US9617273, ...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207566(US10501467, Example 11 | US9260440, 11 | US9617273...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207562(US10501467, Example 7 | US9260440, 7 | US9617273, ...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207600(US10501467, Example 45 | US9260440, 45 | US9617273...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA
LigandPNGBDBM50609269(CHEMBL5269810)
Affinity DataIC50:  0.822nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207624(US10501467, Example 69 | US9260440, 69 | US9617273...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553494(CHEMBL4764625)
Affinity DataIC50:  1nMAssay Description:Inhibition of His-tagged human CDK9/cyclin T1 expressed in insect cells using biotin Ttds-YISPLKSPYKISEG as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207617(US9260440, 62 | US9617273, Example 62)
Affinity DataIC50:  1nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM50609268(CHEMBL5286791)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207557(US9260440, 2 | US9617273, Example 2)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM50609267(CHEMBL5283453)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of CDK9 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207573(US10501467, Example 18 | US9260440, 18 | US9617273...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207624(US10501467, Example 69 | US9260440, 69 | US9617273...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells pre-incubated for 30 mins before add...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207565(US10501467, Example 10 | US9260440, 10 | US9617273...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA
LigandPNGBDBM293424(US10106527, Compound 10 | US10106527, Compound 142...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM50238867(CHEMBL4083249)
Affinity DataIC50:  2nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataIC50:  2nMAssay Description:Inhibition of human CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553492(CHEMBL4743292)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of His-tagged human CDK9/cyclin T1 expressed in insect cells using biotin Ttds-YISPLKSPYKISEG as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA
LigandPNGBDBM50609268(CHEMBL5286791)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))TBA
LigandPNGBDBM293424(US10106527, Compound 10 | US10106527, Compound 142...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))TBA
LigandPNGBDBM50239782(CHEMBL4082113)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human CLK4More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207604(US10501467, Example 49 | US9260440, 49 | US9617273...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells pre-incubated for 30 mins before add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA
LigandPNGBDBM50609267(CHEMBL5283453)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM354126(US9796708, Example 1358 | trans-4-{4-[5-fluoro-4-(...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of CDK9 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))TBA
LigandPNGBDBM50469189(CHEMBL4284209)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207586(US10501467, Example 31 | US9260440, 31 | US9617273...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells pre-incubated for 30 mins before add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50243953(CHEMBL4101340)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant human mTOR (1362 to end residues)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50243924(CHEMBL4075931)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant human mTOR (1362 to end residues)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50243948(CHEMBL4096248)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant human mTOR (1362 to end residues)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553483(CHEMBL4756595 | US20230416221, Compound BAY1251152)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553497(CHEMBL4753804)
Affinity DataIC50:  3nMAssay Description:Inhibition of His-tagged human CDK9/cyclin T1 expressed in insect cells using biotinylated-cdk7tide peptide incubated for 5 hrs by Alpha Screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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