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Found 117 with Last Name = 'reid' and Initial = 'ja'
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107460((S)-1-((R)-3-Phenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataKi:  0.460nMAssay Description:Competitive kinetic for thrombin inhibition Ki was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50449917(BMS-180560 | CHEMBL2021417)
Affinity DataKi:  0.800nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50366780(BMS-189090 | CHEMBL138877)
Affinity DataKi:  3.40nMAssay Description:In vitro reversible inhibition of thrombin catalytic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50449914(CHEMBL2079784)
Affinity DataKi:  4.5nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449919(CHEMBL2021415)
Affinity DataKi:  6.30nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50366331(CHEMBL1790055)
Affinity DataKi:  6.30nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449910(CHEMBL2079782)
Affinity DataKi:  7.30nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107463((S)-1-((R)-2-Methanesulfonylamino-3-phenyl-propion...)
Affinity DataKi:  8.20nMAssay Description:Competitive kinetic for human alpha thrombin inhibition Ki was determinedMore data for this Ligand-Target Pair
LigandPNGBDBM50449912(CHEMBL2079781)
Affinity DataKi:  8.90nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449909(CHEMBL2079769)
Affinity DataKi:  13nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449918(BMS-181688 | CHEMBL2021416)
Affinity DataKi:  25nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449920(CHEMBL2079768)
Affinity DataKi:  30nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449911(CHEMBL2079770)
Affinity DataKi:  39nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282240(CHEMBL288691 | Lithium; 2-[4-(2-butyl-5-hydroxymet...)
Affinity DataKi:  79nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449915(CHEMBL2021419)
Affinity DataKi:  79nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282248(CHEMBL287065 | Lithium; 2-[5-(2-butyl-5-hydroxymet...)
Affinity DataKi:  760nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449916(CHEMBL2021418)
Affinity DataKi:  840nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282244(2-Butyl-3-{1-[2-(2H-tetrazol-5-yl)-phenyl]-1H-indo...)
Affinity DataKi:  3.60E+3nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282254(CHEMBL36259 | Potassium; 2-[6-(2-butyl-4-chloro-5-...)
Affinity DataKi:  6.10E+3nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-2 angiotensin II receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50449917(BMS-180560 | CHEMBL2021417)
Affinity DataKi:  6.50E+3nMAssay Description:Receptor binding affinity for Angiotensin II receptor, type 2 determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281226(CHEMBL328736 | N-[(S)-1-[(2R,3S)-4-((R)-Butylsulfa...)
Affinity DataIC50:  0.350nMpH: 7.0Assay Description:The compound was tested for its inhibitory activity against human renal renin at pH 7More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281231((S)-4-Methyl-2-[(S)-2-(2-methyl-propane-2-sulfonyl...)
Affinity DataIC50:  1.70nMpH: 7.0Assay Description:The compound was tested for its inhibitory activity against human renal renin at pH 7More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107460((S)-1-((R)-3-Phenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity against hydrolysis of human alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107460((S)-1-((R)-3-Phenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity against hydrolysis of thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107461((S)-1-((R)-3-Phenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory activity against hydrolysis of human alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281229(1H-Indole-2-carboxylic acid [(S)-1-[4-((S,S,R)-but...)
Affinity DataIC50:  11nMpH: 7.0Assay Description:The compound was tested for its inhibitory activity against human renal renin at pH 7More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107445((S)-4-((S)-2-{[((S)-1-Carbamimidoyl-piperidine-3-c...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107455(4-Carbamimidoyl-N-{(S)-1-[(S)-3-hydroxy-2-(naphtha...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50366780(BMS-189090 | CHEMBL138877)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50366780(BMS-189090 | CHEMBL138877)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibitory activity against hydrolysis of human alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of thrombin catalytic activity using s-2238 substrate at 10 uM was measured at rt after 3 min incubation with compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107446(1-Carbamimidoyl-piperidine-3-carboxylic acid {(S)-...)
Affinity DataIC50:  32nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50038001((2R,4R)-1-((S)-5-(diaminomethyleneamino)-2-(3-meth...)
Affinity DataIC50:  38nMAssay Description:In vitro inhibitory activity against hydrolysis of human alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50038001((2R,4R)-1-((S)-5-(diaminomethyleneamino)-2-(3-meth...)
Affinity DataIC50:  38nMAssay Description:In vitro inhibition of thrombin catalytic activity using s-2238 substrate at 10 uM was measured at rat after 3 min incubation with compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107463((S)-1-((R)-2-Methanesulfonylamino-3-phenyl-propion...)
Affinity DataIC50:  46nMAssay Description:In vitro inhibitory activity against hydrolysis of human alpha thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107442(6-Guanidino-hexanoic acid {(S)-1-[(S)-3-hydroxy-2-...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281234((S)-N-[(S)-4-((R,R)-Butylsulfamoyl)-1-cyclohexylme...)
Affinity DataIC50:  64nMpH: 7.0Assay Description:The compound was tested for its inhibitory activity against human renal renin at pH 7More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107473((S)-1-((R)-2-Methanesulfonylamino-3-phenyl-propion...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibitory activity against hydrolysis of human alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107434(1-Carbamimidoyl-piperidine-3-carboxylic acid {(S)-...)
Affinity DataIC50:  75nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107453(5-Guanidino-pentanoic acid {(S)-1-[(S)-3-hydroxy-2...)
Affinity DataIC50:  80nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107449(1-Carbamimidoyl-piperidine-4-carboxylic acid {(S)-...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107447(2-(1-Carbamimidoyl-piperidin-4-yl)-N-{(S)-1-[(S)-3...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281242((S)-N-[(S)-4-((R,R)-Butylsulfamoyl)-1-cyclohexylme...)
Affinity DataIC50:  240nMpH: 7.0Assay Description:The compound was tested for its inhibitory activity against human renal renin at pH 7More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107439(1-Carbamimidoyl-piperidine-3-carboxylic acid {(S)-...)
Affinity DataIC50:  310nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107444(4-Guanidino-N-{(S)-1-[(S)-3-hydroxy-2-(naphthalene...)
Affinity DataIC50:  390nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50451350(CHEMBL2111938)
Affinity DataIC50:  500nMAssay Description:In vitro inhibition of thrombin catalytic activity using s-2238 substrate at 10 uM was measured at rat after 3 min incubation with compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107450((R)-1-Carbamimidoyl-piperidine-3-carboxylic acid {...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50064652((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataIC50:  540nMAssay Description:In vitro inhibitory activity against hydrolysis of human alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107441((2S,4S)-1-[(S)-3-Hydroxy-2-(naphthalene-2-sulfonyl...)
Affinity DataIC50:  620nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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