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Found 143 with Last Name = 'roscilli' and Initial = 'g'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316229(2-(1,2,3,4-tetrahydroisoquinolin-6-yl)-2H-indazole...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  1.40nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  1.60nMAssay Description:Binding affinity to human ER alphaMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316242(2-(4-(piperidin-1-ylmethyl)phenyl)-2H-indazole-7-c...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human PARP2 by trichloroacetic acid precipitation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316237(2-(4-{[(2-Fluoroethyl)amino]methyl}phenyl)-2H-inda...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316230(2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-2H-indazole...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316225((R)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316228(2-(4-(pyrrolidin-2-yl)phenyl)-2H-indazole-7-carbox...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316225((R)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316244(2-(4-((dimethylamino)methyl)phenyl)-2H-indazole-7-...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316234(2-(4-(1-(methylamino)ethyl)phenyl)-2H-indazole-7-c...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306210(2-(4-((methylamino)methyl)phenyl)-2H-indazole-7-ca...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316238(2-{4-[(Ethylamino)methyl]phenyl}-2H-indazole-7-car...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316243(2-[4-(Pyrrolidin-1-ylmethyl)phenyl]-2H-indazole-7-...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
"Sapienza" Universit£

Curated by ChEMBL
LigandPNGBDBM50466629(CHEMBL4280766)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant HPSE (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316231(2-(3-((methylamino)methyl)phenyl)-2H-indazole-7-ca...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316239(2-(4-(((2-(dimethylamino)ethyl)(methyl)amino)methy...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316235(2-(4-((isopropylamino)methyl)phenyl)-2H-indazole-7...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316227(2-(4-(piperidin-4-yl)phenyl)-2H-indazole-7-carboxa...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194081(9a-benzyl-7-hydroxy-4-methyl-1,2,9,9a-tetrahydro-3...)
Affinity DataIC50:  14nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316249(2-(3-Chlorophenyl)-2H-indazole-7-carboxamide | CHE...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316236(2-(4-{[(2,2-Difluoroethyl)amino]methyl}phenyl)-2H-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316233(2-(4-(2-(methylamino)propan-2-yl)phenyl)-2H-indazo...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316241(2-[4-(Morpholin-4-ylmethyl)phenyl]-2H-indazole-7-c...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194087(1-{2-[4-(9a-benzyl-7-hydroxy-3-oxo-2,3,9,9a-tetrah...)
Affinity DataIC50:  22nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194080(9a-(4-chlorobenzyl)-7-hydroxy-4-methyl-1,2,9,9a-te...)
Affinity DataIC50:  22nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306166(2-phenyl-2H-indazole-7-carboxamide | CHEMBL594298)
Affinity DataIC50:  24nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316248(2-(4-Chlorophenyl)-2H-indazole-7-carboxamide | CHE...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194088(9a-benzyl-4-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H...)
Affinity DataIC50:  25nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194091(4-{2-[4-(9a-benzyl-7-hydroxy-3-oxo-2,3,9,9a-tetrah...)
Affinity DataIC50:  25nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194084(9a-benzyl-7-hydroxy-4-(4-hydroxyphenyl)-1,2,9,9a-t...)
Affinity DataIC50:  29nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194075(9a-(4-chlorobenzyl)-7-hydroxy-4-[4-(2-piperidin-1-...)
Affinity DataIC50:  29nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316240(2-{4-[(4-Methylpiperazin-1-yl)methyl]phenyl}-2H-in...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194076(2-[4-(9a-benzyl-7-hydroxy-3-oxo-2,3,9,9a-tetrahydr...)
Affinity DataIC50:  40nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  46nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316246(2-phenylpyrazolo-[1,5-a]pyridine-7-carboxamide | C...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316247(2-phenyl-2H-benzo[d][1,2,3]triazole-4-carboxamide ...)
Affinity DataIC50:  71nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
"Sapienza" Universit£

Curated by ChEMBL
LigandPNGBDBM50466636(CHEMBL4286441)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant HPSE (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194077(9a-(4-fluorobenzyl)-6-methyl-8,9,9a,10-tetrahydroi...)
Affinity DataIC50:  82nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194084(9a-benzyl-7-hydroxy-4-(4-hydroxyphenyl)-1,2,9,9a-t...)
Affinity DataIC50:  100nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316250(2-(2-Chlorophenyl)-2H-indazole-7-carboxamide | CHE...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194082(9a-benzyl-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-8...)
Affinity DataIC50:  110nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316251(2-Benzyl-2H-indazole-7-carboxamide | CHEMBL1094951)
Affinity DataIC50:  130nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194082(9a-benzyl-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-8...)
Affinity DataIC50:  130nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194085(9a-(2-fluorobenzyl)-6-methyl-8,9,9a,10-tetrahydroi...)
Affinity DataIC50:  140nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194089(9a-benzyl-6-methyl-8,9,9a,10-tetrahydroindeno[2,1-...)
Affinity DataIC50:  160nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
"Sapienza" Universit£

Curated by ChEMBL
LigandPNGBDBM50506597(CHEMBL4576477)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant HPSE GS3 (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 based colorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
"Sapienza" Universit£

Curated by ChEMBL
LigandPNGBDBM50466651(CHEMBL4283251)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant HPSE (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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