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Found 823 with Last Name = 'ryono' and Initial = 'de'
LigandPNGBDBM50449917(BMS-180560 | CHEMBL2021417)
Affinity DataKi:  0.800nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282324(2-Cyclopropyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50049201(2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50049201(2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-...)
Affinity DataKi:  2.90nMAssay Description:Receptor binding affinity determined from competitive binding assay using 1251 labelled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282318(2-Methyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-yloxy...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282322(2-Propyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-yloxy...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449914(CHEMBL2079784)
Affinity DataKi:  4.5nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282316(2-Cyclopropyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282315(2-Ethyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-yloxy]...)
Affinity DataKi:  5.90nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50366331(CHEMBL1790055)
Affinity DataKi:  6.30nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449919(CHEMBL2021415)
Affinity DataKi:  6.30nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449910(CHEMBL2079782)
Affinity DataKi:  7.30nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449912(CHEMBL2079781)
Affinity DataKi:  8.90nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282317(2-Cyclopropyl-5-methyl-3-[2'-(2H-tetrazol-5-yl)-bi...)
Affinity DataKi:  12nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449909(CHEMBL2079769)
Affinity DataKi:  13nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282319(2-Cyclopropyl-6-fluoro-3-[2'-(2H-tetrazol-5-yl)-bi...)
Affinity DataKi:  14nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449918(BMS-181688 | CHEMBL2021416)
Affinity DataKi:  25nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449920(CHEMBL2079768)
Affinity DataKi:  30nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282321(7-Chloro-2-cyclopropyl-3-[2'-(2H-tetrazol-5-yl)-bi...)
Affinity DataKi:  32nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282313(2-Cyclopropyl-6-methoxy-3-[2'-(2H-tetrazol-5-yl)-b...)
Affinity DataKi:  33nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449911(CHEMBL2079770)
Affinity DataKi:  39nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449915(CHEMBL2021419)
Affinity DataKi:  79nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282240(CHEMBL288691 | Lithium; 2-[4-(2-butyl-5-hydroxymet...)
Affinity DataKi:  79nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282323(2-Cyclopropyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-...)
Affinity DataKi:  120nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282248(CHEMBL287065 | Lithium; 2-[5-(2-butyl-5-hydroxymet...)
Affinity DataKi:  760nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449916(CHEMBL2021418)
Affinity DataKi:  840nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282320(2-Cyclopropyl-8-methyl-3-[2'-(2H-tetrazol-5-yl)-bi...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282244(2-Butyl-3-{1-[2-(2H-tetrazol-5-yl)-phenyl]-1H-indo...)
Affinity DataKi:  3.60E+3nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282254(CHEMBL36259 | Potassium; 2-[6-(2-butyl-4-chloro-5-...)
Affinity DataKi:  6.10E+3nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-2 angiotensin II receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50449917(BMS-180560 | CHEMBL2021417)
Affinity DataKi:  6.50E+3nMAssay Description:Receptor binding affinity for Angiotensin II receptor, type 2 determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18867(2-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)phenoxy...)
Affinity DataIC50:  0.0950nM EC50:  0.200nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18867(2-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)phenoxy...)
Affinity DataIC50:  0.100nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18913(2-{3,5-dichloro-4-[3-(3-ethylphenyl)-4-hydroxyphen...)
Affinity DataIC50:  0.200nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataIC50:  0.240nMAssay Description:Inhibitory concentration against cloned human thyroid hormone receptor alpha 1More data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataIC50:  0.240nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataIC50:  0.240nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataIC50:  0.260nMAssay Description:Inhibitory concentration against cloned human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataIC50:  0.260nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataIC50:  0.260nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18874((2S)-2-(1-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl...)
Affinity DataIC50:  0.270nM EC50:  0.770nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM50171802(CHEMBL196642 | N-[3,5-Dichloro-4-(5-isopropyl-6-me...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory concentration against cloned human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM50171808(CHEMBL194242 | N-[4-(5-Bromo-6-hydroxy-naphthalen-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory concentration against cloned human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM50171801(CHEMBL198367 | N-[4-(5-Bromo-6-hydroxy-naphthalen-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory concentration against cloned human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281226(CHEMBL328736 | N-[(S)-1-[(2R,3S)-4-((R)-Butylsulfa...)
Affinity DataIC50:  0.350nMpH: 7.0Assay Description:The compound was tested for its inhibitory activity against human renal renin at pH 7More data for this Ligand-Target Pair
In DepthDetails Article
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18954(2-(3,5-dibromo-4-{3-[(2,2-diphenylethyl)carbamoyl]...)
Affinity DataIC50:  0.470nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18877((2R)-2-(1-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl...)
Affinity DataIC50:  0.600nM EC50:  0.730nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18948(2-(3,5-dibromo-4-{4-hydroxy-3-[(2-phenylethyl)carb...)
Affinity DataIC50:  0.620nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18875((2R)-2-(1-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl...)
Affinity DataIC50:  0.710nM EC50:  1.20nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18927(2-(3,5-dichloro-4-{3-[3-(difluoromethoxy)phenyl]-4...)
Affinity DataIC50:  0.770nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18876((2S)-2-(1-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl...)
Affinity DataIC50:  0.780nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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