TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.100nMAssay Description:Inhibition of recombinant full length wild-type CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as reduction in p...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Inhibition of recombinant full length wild-type CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as reduction in p...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.150nMAssay Description:Inhibition of recombinant full length wild-type CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as reduction in p...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:Inhibition of recombinant full length wild-type CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as reduction in p...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Inhibition of human full length recombinant HPK1 using 5FAM-AKRRRLSSLRACOOH as substrate preincubated for 20 mins and measured for 60 mins by microfl...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Inhibition of human full length recombinant HPK1 using 5FAM-AKRRRLSSLRACOOH as substrate preincubated for 20 mins and measured for 60 mins by microfl...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Inhibition of human full length recombinant HPK1 using 5FAM-AKRRRLSSLRACOOH as substrate preincubated for 20 mins and measured for 60 mins by microfl...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Inhibition of human full length recombinant HPK1 using 5FAM-AKRRRLSSLRACOOH as substrate preincubated for 20 mins and measured for 60 mins by microfl...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Inhibition of human full length recombinant HPK1 using 5FAM-AKRRRLSSLRACOOH as substrate preincubated for 20 mins and measured for 60 mins by microfl...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Inhibition of human full length recombinant HPK1 using 5FAM-AKRRRLSSLRACOOH as substrate preincubated for 20 mins and measured for 60 mins by microfl...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.460nMAssay Description:Inhibition of recombinant full length wild-type CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as reduction in p...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.770nMAssay Description:Inhibition of recombinant full length wild-type CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as reduction in p...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.780nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant GSK3beta H350L mutant expressed in baculovirus-infected Sf21 cells assessed as reduction in pr...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 0.950nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant GSK3beta H350L mutant expressed in baculovirus-infected Sf21 cells assessed as reduction in pr...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant GSK3beta H350L mutant expressed in baculovirus-infected Sf21 cells assessed as reduction in pr...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant GSK3beta H350L mutant expressed in baculovirus-infected Sf21 cells assessed as reduction in pr...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant GSK3beta H350L mutant expressed in baculovirus-infected Sf21 cells assessed as reduction in pr...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant GSK3beta H350L mutant expressed in baculovirus-infected Sf21 cells assessed as reduction in pr...More data for this Ligand-Target Pair
Affinity DataIC50: 0nMAssay Description:Inhibition of HDAC1 (unknown origin) preincubated for 10 mins followed by tripeptide substrate addition and measured after 60 mins by fluorescence mi...More data for this Ligand-Target Pair
Affinity DataIC50: 0nMAssay Description:Inhibition of HDAC1 (unknown origin) preincubated for 10 mins followed by tripeptide substrate addition and measured after 60 mins by fluorescence mi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.00720nMAssay Description:Inhibition of MGL activity in human HeLa cells assessed as reduction in cleaved [1,3-3H glycerol] level using [glycerol-1,3-3H]-oleoyl glycerol as su...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human recombinant ACSS2 incubated for 180 mins by AMP Glo assayMore data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into histones measured after 24 hrs by scintillation co...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human recombinant ACSS2 incubated for 180 mins by AMP Glo assayMore data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human recombinant ACSS2 incubated for 180 mins by AMP Glo assayMore data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into fatty acids by microbeta scintillation counting an...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into fatty acids by microbeta scintillation counting an...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into fatty acids by microbeta scintillation counting an...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into fatty acids by microbeta scintillation counting an...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into histones by microbeta scintillation counting analy...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into histones by microbeta scintillation counting analy...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into histones by microbeta scintillation counting analy...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into histones by microbeta scintillation counting analy...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into histones by microbeta scintillation counting analy...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human recombinant ACSS2 incubated for 180 mins by AMP Glo assayMore data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into histones measured after 24 hrs by scintillation co...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into fatty acids measured after 24 hrs by scintillation...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into fatty acids measured after 24 hrs by scintillation...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into fatty acids measured after 24 hrs by scintillation...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human recombinant ACSS2 assessed as AMP release using Coenzyme A/ATP as co-substrates by AMP Glo assayMore data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human recombinant ACSS2 assessed as AMP release using Coenzyme A/ATP as co-substrates by AMP Glo assayMore data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into fatty acids measured after 24 hrs by scintillation...More data for this Ligand-Target Pair
TargetAcetyl-coenzyme A synthetase, cytoplasmic(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into fatty acids measured after 24 hrs by scintillation...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0190nMAssay Description:Inhibition of MGL activity in human HeLa cells assessed as reduction in cleaved [1,3-3H glycerol] level using [glycerol-1,3-3H]-oleoyl glycerol as su...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0240nMAssay Description:Inhibition of MGL activity in human HeLa cells assessed as reduction in cleaved [1,3-3H glycerol] level using [glycerol-1,3-3H]-oleoyl glycerol as su...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: <0.0300nMAssay Description:Inhibition of recombinant human full-length His-tagged IRAK4 expressed in baculovirus infected insect cells using KKARFSRFAGSSPSQSSMVAR as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0340nMAssay Description:Inhibition of MGL activity in human HeLa cells assessed as reduction in cleaved [1,3-3H glycerol] level using [glycerol-1,3-3H]-oleoyl glycerol as su...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...More data for this Ligand-Target Pair