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Found 1669 with Last Name = 'sanchez' and Initial = 't'
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM23398((2Z)-1-{5-[(4-fluorophenyl)methyl]furan-2-yl}-3-hy...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit catalytic activity of human immuno deficiency virus type 1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  22nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before substrate addition and measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  136nMAssay Description:Inhibition of human recombinant HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataIC50:  189nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522146(CHEMBL4469317)
Affinity DataIC50:  195nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50145950((Z)-4-{3-[[3-(3-Carboxy-3-hydroxy-acryloyl)-phenyl...)
Affinity DataIC50:  200nMAssay Description:Inhibition of HIV-1 integrase catalytic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50145954((Z)-4-[3-(2-Fluoro-benzyl)-phenyl]-2-hydroxy-4-oxo...)
Affinity DataIC50:  200nMAssay Description:Inhibition of HIV-1 integrase catalytic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50485906(CHEMBL2180587)
Affinity DataIC50:  200nMAssay Description:Inhibition of HIV1 integrase strand transfer activity using [32P]-labeled linear oligonucleotide substrateMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50145948((Z)-4-[3-(2-Fluoro-benzyl)-phenyl]-2-hydroxy-4-oxo...)
Affinity DataIC50:  200nMAssay Description:Inhibition of HIV-1 integrase catalytic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50485904(CHEMBL2180591)
Affinity DataIC50:  200nMAssay Description:Inhibition of HIV1 integrase strand transfer activity using [32P]-labeled linear oligonucleotide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522150(CHEMBL4466520)
Affinity DataIC50:  235nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522151(CHEMBL4571280)
Affinity DataIC50:  258nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522148(CHEMBL4454331)
Affinity DataIC50:  278nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522145(CHEMBL4463774)
Affinity DataIC50:  292nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522149(CHEMBL4516302)
Affinity DataIC50:  296nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50021581(CHEMBL414850 | L-870810)
Affinity DataIC50:  300nMAssay Description:Inhibition of HIV1 integrase strand transfer activity using [32P]-labeled linear oligonucleotide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50145952((Z)-4-[3-(2-Fluoro-benzyl)-phenyl]-1-(4-{4-[3-(2-f...)
Affinity DataIC50:  300nMAssay Description:Inhibition of HIV-1 integrase catalytic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50485914(CHEMBL2180590)
Affinity DataIC50:  300nMAssay Description:Inhibition of HIV1 integrase strand transfer activity using [32P]-labeled linear oligonucleotide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50145958((Z)-4-(3-{2-[3-(3-Carboxy-3-hydroxy-acryloyl)-phen...)
Affinity DataIC50:  300nMAssay Description:Inhibition of HIV-1 integrase catalytic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50485905(CHEMBL2180589)
Affinity DataIC50:  300nMAssay Description:Inhibition of HIV1 integrase strand transfer activity using [32P]-labeled linear oligonucleotide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522142(CHEMBL566831)
Affinity DataIC50:  370nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522144(CHEMBL4466864)
Affinity DataIC50:  371nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50476357(CHEMBL389930)
Affinity DataIC50:  380nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50017683(CHEMBL3286423)
Affinity DataIC50:  380nMAssay Description:Inhibition of His6-tagged HIV-1 integrase assessed as decrease in integrase-Flag-LEDGF/p75 interaction preincubated with enzyme for 30 mins followed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522146(CHEMBL4469317)
Affinity DataIC50:  381nMAssay Description:Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before substrate addition and measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50479075(CHEMBL492770)
Affinity DataIC50: <400nMAssay Description:Inhibition of wild-type HIV1 integrase strand transfer activity using [32P]-labeled linear oligonucleotide substrate by polyacrylamide gel electropho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50095515(4-[3-(2-Fluoro-benzyl)-phenyl]-2,4-dioxo-butyric a...)
Affinity DataIC50:  400nMAssay Description:Inhibition of HIV-1 integrase catalytic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50479066(CHEMBL454190)
Affinity DataIC50: <400nMAssay Description:Inhibition of wild-type HIV1 integrase strand transfer activity using [32P]-labeled linear oligonucleotide substrate by polyacrylamide gel electropho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50479081(CHEMBL467149)
Affinity DataIC50: <400nMAssay Description:Inhibition of wild-type HIV1 integrase strand transfer activity using [32P]-labeled linear oligonucleotide substrate by polyacrylamide gel electropho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50145957((Z)-4-(3-{3-[3-(3-Carboxy-3-hydroxy-acryloyl)-phen...)
Affinity DataIC50:  400nMAssay Description:Inhibition of HIV-1 integrase catalytic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522143(CHEMBL4518387)
Affinity DataIC50:  415nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522147(CHEMBL4573804)
Affinity DataIC50:  420nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522151(CHEMBL4571280)
Affinity DataIC50:  449nMAssay Description:Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before substrate addition and measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  450nMAssay Description:Inhibition of His6-tagged HIV-1 integrase assessed as decrease in integrase-Flag-LEDGF/p75 interaction preincubated with enzyme for 30 mins followed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522147(CHEMBL4573804)
Affinity DataIC50:  463nMAssay Description:Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before substrate addition and measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50023421(CHEMBL3334637)
Affinity DataIC50:  500nMAssay Description:Inhibition of HIV1 recombinant wild type integrase strand transfer activity by gel-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50485907(CHEMBL2180599)
Affinity DataIC50:  500nMAssay Description:Inhibition of HIV1 integrase strand transfer activity using [32P]-labeled linear oligonucleotide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50023423(CHEMBL3334635)
Affinity DataIC50:  500nMAssay Description:Inhibition of HIV1 recombinant wild type integrase strand transfer activity by gel-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM23399(4-{1-[(4-fluorophenyl)methyl]-1H-pyrrol-2-yl}-2,4-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of HIV-1 integrase catalytic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50476341(CHEMBL225681)
Affinity DataIC50:  530nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM23399(4-{1-[(4-fluorophenyl)methyl]-1H-pyrrol-2-yl}-2,4-...)
Affinity DataIC50:  540nMAssay Description:Inhibition of HIV1 integrase strand transfer activity by PAGEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50476348(GSK-S-1360 | GW-810781 | Gw810781 | S 1360 | S-136...)
Affinity DataIC50:  600nMAssay Description:Inhibition of Human immunodeficiency virus 1 integrase strand transfer activity after 30 mins by polyacrylamide gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50476348(GSK-S-1360 | GW-810781 | Gw810781 | S 1360 | S-136...)
Affinity DataIC50:  600nMAssay Description:Inhibition of Human immunodeficiency virus 1 integrase strand transfer activity after 30 mins by polyacrylamide gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  600nMAssay Description:Inhibition of His6-tagged HIV-1 integrase assessed as decrease in integrase-Flag-LEDGF/p75 interaction preincubated with enzyme for 30 mins followed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50477606(CHEMBL240506)
Affinity DataIC50:  600nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50479058(CHEMBL467380)
Affinity DataIC50:  600nMAssay Description:Inhibition of wild-type HIV1 integrase strand transfer activity using [32P]-labeled linear oligonucleotide substrate by polyacrylamide gel electropho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50023425(CHEMBL3334633)
Affinity DataIC50:  600nMAssay Description:Inhibition of HIV1 recombinant wild type integrase strand transfer activity by gel-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50476348(GSK-S-1360 | GW-810781 | Gw810781 | S 1360 | S-136...)
Affinity DataIC50:  600nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50522149(CHEMBL4516302)
Affinity DataIC50:  602nMAssay Description:Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before substrate addition and measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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