Affinity DataKi: 0.00340nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.0300nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.0300nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.0300nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.0300nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 0.0460nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
Affinity DataKi: 0.0500nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.0700nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
Affinity DataKi: 0.0900nMAssay Description:In vitro inhibition of the compound against human thrombin was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.200nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.200nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.210nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.210nM ΔG°: -57.5kJ/molepH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.310nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.390nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.390nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.410nM ΔG°: -55.7kJ/mole IC50: 2.20nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.410nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.530nM ΔG°: -55.1kJ/mole IC50: 1.80nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.530nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 0.540nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.670nM ΔG°: -54.5kJ/mole IC50: 2.70nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.670nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.700nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.700nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.830nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 0.830nM ΔG°: -53.9kJ/molepH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 1.04nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 1.10nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 1.10nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 1.40nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research
Parke-Davis Pharmaceutical Research
Affinity DataKi: 1.40nM ΔG°: -52.6kJ/molepH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair