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Found 94 with Last Name = 'sankaranarayanan' and Initial = 'nv'
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50425968(CHEMBL2314388)
Affinity DataIC50:  40nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50501886(CHEMBL4475009)
Affinity DataIC50:  140nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260048(CHEMBL4084933)
Affinity DataIC50:  230nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50501891(CHEMBL4538120)
Affinity DataIC50:  250nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260045(CHEMBL4103815)
Affinity DataIC50:  320nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260052(CHEMBL4079552)
Affinity DataIC50:  640nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260049(CHEMBL4104474)
Affinity DataIC50:  690nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260053(CHEMBL4076224)
Affinity DataIC50:  810nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260049(CHEMBL4104474)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human leukocyte cathepsin G using S7388 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260058(CHEMBL4095129)
Affinity DataIC50:  1.56E+3nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50501887(CHEMBL4454043)
Affinity DataIC50:  2.19E+3nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260051(CHEMBL4102885)
Affinity DataIC50:  2.65E+3nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260048(CHEMBL4084933)
Affinity DataIC50:  2.80E+3nMAssay Description:Binding affinity to human plasmin assessed as loss of intrinsic tryptophan fluorescence at 250 uM by spectrofluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50501893(CHEMBL4435942)
Affinity DataIC50:  3.23E+3nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260048(CHEMBL4084933)
Affinity DataIC50:  3.60E+3nMAssay Description:Allosteric inhibition of human plasmin using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate addition measured ove...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260048(CHEMBL4084933)
Affinity DataIC50:  4.60E+3nMAssay Description:Allosteric inhibition of human plasmin assessed as delay in clot lysis after 410 mins by spectrophotometer methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260048(CHEMBL4084933)
Affinity DataIC50:  6.10E+3nMAssay Description:Binding affinity to human dansyl-EGR-chloromethylketone-plasmin complex assessed as loss of intrinsic tryptophan fluorescence by spectrofluorometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260048(CHEMBL4084933)
Affinity DataIC50:  6.30E+3nMAssay Description:Allosteric inhibition of human plasmin using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate addition measured ove...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50501890(CHEMBL4578588)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260045(CHEMBL4103815)
Affinity DataIC50:  6.50E+3nMAssay Description:Allosteric inhibition of full length human plasmin by using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50501894(CHEMBL4569385)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612136(CHEMBL5271926)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260048(CHEMBL4084933)
Affinity DataIC50:  8.80E+3nMAssay Description:Allosteric inhibition of human plasmin using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate addition measured ove...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50501888(CHEMBL4452555)
Affinity DataIC50:  1.01E+4nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260048(CHEMBL4084933)
Affinity DataIC50:  1.04E+4nMAssay Description:Allosteric inhibition of human plasmin using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate addition measured ove...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260062(CHEMBL4088109)
Affinity DataIC50:  1.40E+4nMAssay Description:Allosteric inhibition of full length human plasmin by using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260048(CHEMBL4084933)
Affinity DataIC50:  1.41E+4nMAssay Description:Allosteric inhibition of full length human plasmin by using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612138(CHEMBL5283360)
Affinity DataIC50:  1.45E+4nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612137(CHEMBL5288069)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260044(CHEMBL4089856)
Affinity DataIC50:  1.91E+4nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260047(CHEMBL4096754)
Affinity DataIC50:  2.00E+4nMAssay Description:Allosteric inhibition of human plasmin using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate addition measured ove...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612135(CHEMBL5285595)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50501892(CHEMBL4523005)
Affinity DataIC50:  2.17E+4nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612142(CHEMBL4463760)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612134(CHEMBL5270082)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260048(CHEMBL4084933)
Affinity DataIC50:  2.59E+4nMAssay Description:Binding affinity to human plasmin assessed as loss of intrinsic tryptophan fluorescence at 250 uM by spectrofluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612143(CHEMBL4574448)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260044(CHEMBL4089856)
Affinity DataIC50:  3.40E+4nMAssay Description:Allosteric inhibition of full length human plasmin by using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260061(CHEMBL4080232)
Affinity DataIC50:  3.40E+4nMAssay Description:Allosteric inhibition of full length human plasmin by using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612132(CHEMBL5284215)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612141(CHEMBL4470825)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612144(CHEMBL4445340)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612133(CHEMBL5267635)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50501889(CHEMBL4464760)
Affinity DataIC50:  3.58E+4nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612146(CHEMBL5279853)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260051(CHEMBL4102885)
Affinity DataIC50:  3.70E+4nMAssay Description:Allosteric inhibition of full length human plasmin by using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))TBA
LigandPNGBDBM50612140(CHEMBL4551546)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260049(CHEMBL4104474)
Affinity DataIC50:  4.20E+4nMAssay Description:Allosteric inhibition of full length human plasmin by using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260059(CHEMBL4069524)
Affinity DataIC50:  4.70E+4nMAssay Description:Allosteric inhibition of full length human plasmin by using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260046(CHEMBL4060852)
Affinity DataIC50:  4.76E+4nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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