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Found 572 with Last Name = 'santos' and Initial = 'c'
TargetProcathepsin L(Homo sapiens (Human))
Universidade Federal De S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50385972(CHEMBL2042470)
Affinity DataKi:  200nMAssay Description:Competitive inhibition of human recombinant cathepsin L expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Universidade Federal De S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50385972(CHEMBL2042470)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50438272(CHEMBL560455)
Affinity DataKi:  500nMAssay Description:Inhibition of Human immunodeficiency virus 1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291573(N-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)a...)
Affinity DataKi:  530nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291413(1-(6-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)a...)
Affinity DataKi:  780nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Universidade Federal De S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50385984(CHEMBL2042454)
Affinity DataKi:  800nMAssay Description:Uncompetitive inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Universidade Federal De S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50385977(CHEMBL2042446)
Affinity DataKi:  800nMAssay Description:Noncompetitive inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Universidade Federal De S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50385966(CHEMBL2042465)
Affinity DataKi:  900nMAssay Description:Competitive inhibition of human recombinant cathepsin L expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Universidade Federal De S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50385962(CHEMBL2042461)
Affinity DataKi:  1.10E+3nMAssay Description:Uncompetitive inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Universidade Federal De S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50385966(CHEMBL2042465)
Affinity DataKi:  1.30E+3nMAssay Description:Competitive inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291455(N-(4-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)a...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50611873(CHEMBL5274020)
Affinity DataKi:  1.40E+3nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))
Universidade Federal De S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50385977(CHEMBL2042446)
Affinity DataKi:  1.50E+3nMAssay Description:Noncompetitive inhibition of human recombinant cathepsin L expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291452(N-((1R,3S)-3-((6-amino-5-(4-phenoxyphenyl)pyrimidi...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Universidade Federal De S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50385962(CHEMBL2042461)
Affinity DataKi:  1.90E+3nMAssay Description:Uncompetitive inhibition of human recombinant cathepsin L expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Universidade Federal De S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50385984(CHEMBL2042454)
Affinity DataKi:  1.90E+3nMAssay Description:Uncompetitive inhibition of human recombinant cathepsin L expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50611878(CHEMBL5273304)
Affinity DataKi:  2.80E+3nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291522(1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)...)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50611869(CHEMBL5268563)
Affinity DataKi:  7.30E+3nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50611871(CHEMBL5271556)
Affinity DataKi:  8.10E+3nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50611877(CHEMBL5287666)
Affinity DataKi:  8.50E+3nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50611876(CHEMBL5275750)
Affinity DataKi:  1.23E+4nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50611870(CHEMBL5289397)
Affinity DataKi:  1.48E+4nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase, glycosomal(Trypanosoma cruzi)
Da Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50438269(CHEMBL2408381)
Affinity DataKi:  1.60E+4nMAssay Description:Competitive inhibition of Trypanosoma cruzi glycosomal GAPDH NAD+ binding site by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase(Leishmania amazonensis)
Instituto De Tecnologia Em Farmacos

Curated by ChEMBL
LigandPNGBDBM50510706(CHEMBL4515068)
Affinity DataKi:  1.70E+4nMAssay Description:Non-competitive inhibition of Leishmania amazonensis arginase using L-arginine as substrate incubated for 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase, glycosomal(Trypanosoma cruzi)
Da Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50438274(CHEMBL2408382)
Affinity DataKi:  1.71E+4nMAssay Description:Competitive inhibition of Trypanosoma cruzi glycosomal GAPDH NAD+ binding site by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50325677(4,8-dihydroxy-7-methoxy-6-(3-methylbut-2-enyl)-2-(...)
Affinity DataKi:  1.81E+4nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase, glycosomal(Trypanosoma cruzi)
Da Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50438268(CHEMBL2408383)
Affinity DataKi:  1.87E+4nMAssay Description:Competitive inhibition of Trypanosoma cruzi glycosomal GAPDH NAD+ binding site by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50611881(CHEMBL5273562)
Affinity DataKi:  2.30E+4nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase, glycosomal(Trypanosoma cruzi)
Da Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50438273(CHEMBL2408384)
Affinity DataKi:  2.95E+4nMAssay Description:Competitive inhibition of Trypanosoma cruzi glycosomal GAPDH NAD+ binding site by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase, glycosomal(Trypanosoma cruzi)
Da Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50438272(CHEMBL560455)
Affinity DataKi:  3.23E+4nMAssay Description:Competitive inhibition of Trypanosoma cruzi glycosomal GAPDH NAD+ binding site by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase, glycosomal(Trypanosoma cruzi)
Da Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50438271(CHEMBL2408385)
Affinity DataKi:  5.76E+4nMAssay Description:Competitive inhibition of Trypanosoma cruzi glycosomal GAPDH NAD+ binding site by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase, glycosomal(Trypanosoma cruzi)
Da Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50438270(CHEMBL2408386)
Affinity DataKi:  5.95E+4nMAssay Description:Competitive inhibition of Trypanosoma cruzi glycosomal GAPDH NAD+ binding site by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase, glycosomal(Trypanosoma cruzi)
Da Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50438270(CHEMBL2408386)
Affinity DataKi:  1.05E+5nMAssay Description:Non-competitive inhibition of Trypanosoma cruzi glycosomal GAPDH active site by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase, glycosomal(Trypanosoma cruzi)
Da Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50438269(CHEMBL2408381)
Affinity DataKi:  1.51E+5nMAssay Description:Non-competitive inhibition of Trypanosoma cruzi glycosomal GAPDH active site by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase, glycosomal(Trypanosoma cruzi)
Da Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50438268(CHEMBL2408383)
Affinity DataKi:  3.05E+5nMAssay Description:Non-competitive inhibition of Trypanosoma cruzi glycosomal GAPDH active site by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205961(2-((R)-1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205952(2-((R)-1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291635(1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)...)
Affinity DataIC50:  0.200nMAssay Description:Covalent inhibition of N-terminal GST-fused human BTK (2-659(end) amino acids) expressed in baculovirus expression system using FITC-AHA-EEPLYWSFPAKK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50519156(CHEMBL4466205)
Affinity DataIC50:  0.200nMAssay Description:Covalent inhibition of N-terminal GST-fused human BTK (2-659(end) amino acids) expressed in baculovirus expression system using FITC-AHA-EEPLYWSFPAKK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205910((3S)-methyl 4-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205937(CHEMBL385325 | N-[(1,3-benzodioxol-5-yl)methyl]-1-...)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205950(2-((R)-1-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)pyrro...)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205947((2R)-1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-y...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50111438(3-{[(Benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-methy...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205932(CHEMBL373623 | N-[(1,3-benzodioxol-5-yl)methyl]-1-...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205911(2-((R)-1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205956(CHEMBL223788 | N-(1,3-benzodioxol-5-ylmethyl)-1-[6...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205954(CHEMBL385334 | N-[(1,3-benzodioxol-5-yl)methyl]-1-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205926(CHEMBL442041 | N-[(1,3-benzodioxol-5-yl)methyl]-1-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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