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Found 493 with Last Name = 'saville-stones' and Initial = 'e'
TargetHistidinol dehydrogenase, chloroplastic(Brassica oleracea var. capitata)
TBA

Curated by ChEMBL
LigandPNGBDBM50267976((S)-3-Amino-1-biphenyl-4-yl-4-(1H-imidazol-4-yl)-b...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of Brassica oleracea (cabbage) histidinol dehydrogenase pre-incubated for 10 min before substrate histidinol addition by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistidinol dehydrogenase, chloroplastic(Brassica oleracea var. capitata)
TBA

Curated by ChEMBL
LigandPNGBDBM50267975((S)-3-Amino-1-(4-bromo-phenyl)-4-(1H-imidazol-4-yl...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of Brassica oleracea (cabbage) histidinol dehydrogenase pre-incubated for 10 min before substrate histidinol addition by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistidinol dehydrogenase, chloroplastic(Brassica oleracea var. capitata)
TBA

Curated by ChEMBL
LigandPNGBDBM50287735((S)-3-Amino-1-(3-amino-phenyl)-4-(1H-imidazol-4-yl...)
Affinity DataKi:  7.40nMAssay Description:Inhibition of Brassica oleracea (cabbage) histidinol dehydrogenase pre-incubated for 10 min before substrate histidinol addition by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistidinol dehydrogenase, chloroplastic(Brassica oleracea var. capitata)
TBA

Curated by ChEMBL
LigandPNGBDBM50267972((S)-3-Amino-4-(1H-imidazol-4-yl)-1-phenyl-butan-2-...)
Affinity DataKi:  7.60nMAssay Description:Inhibition of Brassica oleracea (cabbage) histidinol dehydrogenase pre-incubated for 10 min before substrate histidinol addition by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50506948(CHEMBL4448806)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552912(CHEMBL4760047)
Affinity DataIC50:  2nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597493(CHEMBL5192610)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552909(CHEMBL4754665)
Affinity DataIC50:  3nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50:  3nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597488(CHEMBL5180112)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597489(CHEMBL5208605)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597490(CHEMBL5199904)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597496(CHEMBL5206259)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM228164(US10047073, 6 | US10047073, 7)
Affinity DataIC50:  3nMAssay Description:The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243152(D1: N-((R)-1-((abs)-3- (Difluoromethoxy)piperidin-...)
Affinity DataIC50:  3nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243173((R)-N-(1-(5-Azaspiro[2.5]octan-5- yl)propan-2-yl)-...)
Affinity DataIC50:  3nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50506921(CHEMBL4459800)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597473(CHEMBL5181094)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243192(N-((2R)-1-(3-Azabicyclo[3.2.0]heptan- 3-yl)propan-...)
Affinity DataIC50:  4nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243193(D1: N-((R)-1-((abs-1,5-cis)-6- Azabicyclo[3.2.0]he...)
Affinity DataIC50:  4nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597492(CHEMBL5186165)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597494(CHEMBL5188032)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243189((R)-N-(1-(3,4-dihydro-2,7-naphthyridin- 2(1H)-yl)p...)
Affinity DataIC50:  6nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597485(CHEMBL5183751)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597487(CHEMBL5169406)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243183(N-((R)-1-(3-Azabicyclo[3.2.1]octan-3- yl)propan-2-...)
Affinity DataIC50:  7nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM228164(US10047073, 6 | US10047073, 7)
Affinity DataIC50:  8nMAssay Description:The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243091(N-((2R)-1-(3-Azabicyclo[3.1.0]hexan-3- yl)propan-2...)
Affinity DataIC50:  8nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243180((R)-N-(1-(5-Azaspiro[2.4]heptan-5- yl)propan-2-yl)...)
Affinity DataIC50:  8nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597475(CHEMBL5200987)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243121((R)-N-(1-(3,4-Dihydroisoquinolin- 2(1H)-yl)propan-...)
Affinity DataIC50:  9nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243202((2S)-1-((R)-2-(3-Fluoro-4-(5- (trifluoromethyl)-1,...)
Affinity DataIC50:  9nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM293916((S)-1-(3,4-Difluoro-2- methylphenyl)-N- hydroxy-3-...)
Affinity DataIC50:  10nMAssay Description:2 μl (200×) of each diluted solution and each control (full activity: 100% DMSO alone or full inhibition 1 mM) is stamped into V-bottomed polypr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM243178((R)-N-(1-(Azepan-1-yl)propan-2-yl)-4- (5-(trifluor...)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM162840(US9056843, 131)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552915(CHEMBL4798111)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM162839(US9056843, 130)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC5 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC7 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC9 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552909(CHEMBL4754665)
Affinity DataIC50:  10nMAssay Description:Inhibition of Class 2A HDAC4 in human Jurkat E6.1 cells using Boc-Lys-(TFA)-AMC as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50552912(CHEMBL4760047)
Affinity DataIC50:  10nMAssay Description:Inhibition of Class 2A HDAC4 in human Jurkat E6.1 cells using Boc-Lys-(TFA)-AMC as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM50161830(CHEMBL3793439)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC4 catalytic domain (unknown origin) using Boc-Lys(TFA)-AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM293880((S)-1-(3-Fluoro-2- methylphenyl)-3-(5- fluoropyrid...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM293886((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(qui...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM293895((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(imi...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM293899((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(6- ...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM293900((S)-3-(5-Chloro-6- methylpyridin-3-yl)-1-(3- fluor...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM293911((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(2- ...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery

Curated by ChEMBL
LigandPNGBDBM293912((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(1-m...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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