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maximum 50k data
Found 652 with Last Name = 'scherle' and Initial = 'pa'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300312(4-amino-1,2,5-oxadiazole-3-carboximidamide | CHEMB...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of N-terminal his-tagged human indoleamine 2,3-dioxygenase expressed in Escherichia coli assessed as N'-formylkynurenine formation by spec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataKi:  3.40E+4nMAssay Description:Competitive inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268371(CHEMBL502247 | N-(2-((1S,2R,4R)-4-(isopropyl(methy...)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315998(CHEMBL1090893 | N-((S)-1-((1S,2R,4R)-4-(ethyl(isop...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [125I]-MCP1 from CCR2 in human THP1 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268423(CHEMBL497202 | N-(2-((1S,2R,4R)-4-(dimethylamino)-...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268423(CHEMBL497202 | N-(2-((1S,2R,4R)-4-(dimethylamino)-...)
Affinity DataIC50:  0.370nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315992(CHEMBL1092678 | N-((S)-1-((1S,2R,4R)-4-(isopropyl(...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [125I]-MCP1 from CCR2 in human THP1 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50371414(CHEMBL271828)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at human CCR2 in PBMCs assessed as inhibition of chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268371(CHEMBL502247 | N-(2-((1S,2R,4R)-4-(isopropyl(methy...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315993(CHEMBL1091605 | N-((S)-1-((1S,2R,4R)-4-(isopropyl(...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis after 45 mins in presence of 0.1 M bovine serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268424(CHEMBL502793 | N-(2-((1S,2R,4R)-4-(diethylamino)-2...)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315989(3-fluoro-N-((S)-1-((1S,2R,4R)-4-(isopropyl(methyl)...)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [125I]-MCP1 from CCR2 in human THP1 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315994(CHEMBL1091604 | N-(2-((1S,2R,4R)-4-(isopropyl(meth...)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [125I]-MCP1 from CCR2 in human THP1 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50391012(CHEMBL2088212)
Affinity DataIC50:  0.900nMAssay Description:Binding affinity to CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50265086((+/-)-2-amino-N-(2-(1-methyl-4-(4-(methylthio)benz...)
Affinity DataIC50:  0.950nMAssay Description:Displacement of radiolabeled MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315993(CHEMBL1091605 | N-((S)-1-((1S,2R,4R)-4-(isopropyl(...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]-MCP1 from CCR2 in human THP1 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50233341(2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylth...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50233341(2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylth...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human CCR2 in PBMCs assessed as inhibition of chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268426(2-amino-N-(2-((1S,2R,4R)-4-(isopropyl(methyl)amino...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50391023(CHEMBL2088388)
Affinity DataIC50:  1.20nMAssay Description:Binding affinity to CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268371(CHEMBL502247 | N-(2-((1S,2R,4R)-4-(isopropyl(methy...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315994(CHEMBL1091604 | N-(2-((1S,2R,4R)-4-(isopropyl(meth...)
Affinity DataIC50:  1.30nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis after 45 mins in presence of 0.1 M bovine serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268424(CHEMBL502793 | N-(2-((1S,2R,4R)-4-(diethylamino)-2...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268426(2-amino-N-(2-((1S,2R,4R)-4-(isopropyl(methyl)amino...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268368(CHEMBL496630 | N-(2-((1S,2R,4R)-4-(methylamino)-2-...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315998(CHEMBL1090893 | N-((S)-1-((1S,2R,4R)-4-(ethyl(isop...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis after 45 mins in presence of 0.5 M bovine serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50265204((+/-)-2-amino-N-(2-(1-methyl-4-(4-(methylthio)benz...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of radiolabeled MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50391024(CHEMBL2088389)
Affinity DataIC50:  1.90nMAssay Description:Binding affinity to CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50391015(CHEMBL2088380)
Affinity DataIC50:  1.90nMAssay Description:Binding affinity to CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50265204((+/-)-2-amino-N-(2-(1-methyl-4-(4-(methylthio)benz...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255171((+/-)-2-amino-N-(2-(5-(isopropylamino)-2-(4-(methy...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255219((+/-)-benzyl-3-(4-(methylthio)benzamido)-4-(2-(3-(...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50265087((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzylamino)-...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268422(CHEMBL502516 | N-(2-((1S,2R,4R)-4-(isopropylamino)...)
Affinity DataIC50:  2.05nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50381179(CHEMBL2018388)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [125-I]MCP1 from CCR2 on human PBMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268374(CHEMBL500175 | tert-butyl 2-(2-((1S,2R,4R)-4-(isop...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255738((+/-)-N-(2-(4-(dimethylamino)-2-(4-(methylthio)ben...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMCsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255219((+/-)-benzyl-3-(4-(methylthio)benzamido)-4-(2-(3-(...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMCsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50391013(CHEMBL2088378)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at CCR2 in human monocytes by chemotaxis assay in presence of 0.5% bovine serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268423(CHEMBL497202 | N-(2-((1S,2R,4R)-4-(dimethylamino)-...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50381182(CHEMBL2018391)
Affinity DataIC50:  2.5nMAssay Description:Displacement of [125-I]MCP1 from CCR2 on human PBMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268366(CHEMBL450231 | N-(2-(2-((1S,2R)-2-((4-(methylthio)...)
Affinity DataIC50:  2.70nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50391014(CHEMBL2088379)
Affinity DataIC50:  2.80nMAssay Description:Binding affinity to CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50265121((+/-)-N-(2-(4-(4-(methylthio)benzylamino)-1-propyl...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50265123((+/-)-3-amino-N-(2-(4-(4-(methylthio)benzylamino)-...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255221((+/-)-N-(2-(2-((1H-indol-5-yl)methylamino)-4-(dime...)
Affinity DataIC50:  3.10nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMCsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50391013(CHEMBL2088378)
Affinity DataIC50:  3.10nMAssay Description:Binding affinity to CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50265087((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzylamino)-...)
Affinity DataIC50:  3.40nMAssay Description:Displacement of radiolabeled MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50381174(CHEMBL2018380)
Affinity DataIC50:  3.40nMAssay Description:Displacement of [125-I]MCP1 from CCR2 on human PBMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50315990(CHEMBL1092748 | N-((S)-1-((1S,2R,4R)-4-(isopropyl(...)
Affinity DataIC50:  3.5nMAssay Description:Displacement of [125I]-MCP1 from CCR2 in human THP1 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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