Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50255219
Substrate
n/a
Meas. Tech.
ChEMBL_516083 (CHEMBL982453)
IC50
2.4±n/a nM
Citation
 Cherney, RJ; Brogan, JB; Mo, R; Lo, YC; Yang, G; Miller, PB; Scherle, PA; Molino, BF; Carter, PH; Decicco, CP Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists. Bioorg Med Chem Lett 19:597-601 (2009) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Human
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50255219
Synonyms:
(+/-)-benzyl-3-(4-(methylthio)benzamido)-4-(2-(3-(trifluoromethyl)benzamido)acetamido)cyclohexylcarbamate | (+/-)-benzyl3-(4-(methylthio)benzamido)-4-( 2-(3-(trifluoromethyl)benzamido)acetamido)cyclohexylcarbamate | CHEMBL505722
Type:
Small organic molecule
Emp. Form.:
C32H33F3N4O5S
Mol. Mass.:
642.688
SMILES:
CSc1ccc(cc1)C(=O)NC1CC(CCC1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)NC(=O)OCc1ccccc1
Structure:
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