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maximum 50k data
Found 152 with Last Name = 'schlemmer' and Initial = 'kh'
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7842(BAY 59-7939 Analog 17 | US8822458, 46)
Affinity DataIC50:  0.400nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7840(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Affinity DataIC50:  0.700nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM12998(5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)...)
Affinity DataIC50:  1nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM12997(5-Chloro-N-({(5S)-3-[3-fluoro-4-(3-oxomorpholin-4-...)
Affinity DataIC50:  1.40nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM12999(BAY 59-7939 Analog 14 | N-({(5S)-3-[3-Amino-4-(3-o...)
Affinity DataIC50:  2.5nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602405(CHEMBL5205373)
Affinity DataIC50:  3nMAssay Description:Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7552(BAY 59-7939 Analog 11 | US8822458, 17)
Affinity DataIC50:  4nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7841(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Affinity DataIC50:  4.20nMAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602402(CHEMBL5181099)
Affinity DataIC50:  6nMAssay Description:Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120247(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  8.5nMAssay Description:Concentration of the compound required to inhibit human recombinant Poly (ADP-ribose) polymerase 1 was determined using doseresponse inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM13008(4-Amino-5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorphol...)
Affinity DataIC50:  8.5nMAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602384(CHEMBL5181101)
Affinity DataIC50: >10nMAssay Description:Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50602376(CHEMBL5189429)
Affinity DataIC50:  10nMAssay Description:Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120236(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120246(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602401(CHEMBL5186852)
Affinity DataIC50:  13nMAssay Description:Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50602404(CHEMBL5207692)
Affinity DataIC50:  13nMAssay Description:Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50602385(CHEMBL5174546)
Affinity DataIC50:  13nMAssay Description:Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120257(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120237(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602398(CHEMBL5198935)
Affinity DataIC50:  15nMAssay Description:Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120269(CHEMBL322133 | N-[2-(4-Bromo-phenyl)-2-oxo-ethyl]-...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120239(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120251(CHEMBL108702 | N-[2-(3'-Amino-biphenyl-4-yl)-2-oxo...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602383(CHEMBL5200395)
Affinity DataIC50:  20nMAssay Description:Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120244(CHEMBL108341 | N-(2-Biphenyl-4-yl-2-oxo-ethyl)-3-(...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120262(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120267(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120261(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM13005(4-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)...)
Affinity DataIC50:  20nMAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120262(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602403(CHEMBL5181856)
Affinity DataIC50:  23nMAssay Description:Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120274(3-(2,4-Dioxo-3,4,5,6,7,8-hexahydro-2H-quinazolin-1...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120254(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120242(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120265(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602378(CHEMBL5174386)
Affinity DataIC50:  25nMAssay Description:Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM13004(5-Bromo-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)p...)
Affinity DataIC50:  26nMAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM13010(5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)...)
Affinity DataIC50:  29nMAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120277(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120253(Benzoic acid 4-{2-[3-(2,4-dioxo-3,4,7,8-tetrahydro...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120256(CHEMBL110115 | N-[2-(4-Difluoromethoxy-phenyl)-2-o...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120238(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  30nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM12990(5-Chloro-N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphen...)
Affinity DataIC50:  32nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120241(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  35nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602380(CHEMBL5205423)
Affinity DataIC50:  35nMAssay Description:Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120272(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120249(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM12992(5-Chloro-N-{[(5S)-3-(3-fluoro-4-pyrrolidin-1-ylphe...)
Affinity DataIC50:  40nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7495(BAY 59-7939 Analog 7 | US8822458, 2)
Affinity DataIC50:  43nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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