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Found 115 with Last Name = 'scott' and Initial = 'mp'
LigandPNGBDBM92649(EPZ004777)
Affinity DataKi:  0.300nM Kd:  0.100nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378462(6-chloro-2-oxo-N-((1R,3r,5S)-8-(((1-(4,4,4-trifluo...)
Affinity DataKi:  1.10nMAssay Description:Non-competitive inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using varyin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378462(6-chloro-2-oxo-N-((1R,3r,5S)-8-(((1-(4,4,4-trifluo...)
Affinity DataKi:  1.20nMAssay Description:Non-competitive inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using fixed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378459(N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)su...)
Affinity DataKi:  1.30nMAssay Description:Non-competitive inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using varyin...More data for this Ligand-Target Pair
LigandPNGBDBM92648(EPZ004450)
Affinity DataKi:  4nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378459(N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)su...)
Affinity DataKi:  4.70nMAssay Description:Mixed type inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using fixed N-ter...More data for this Ligand-Target Pair
LigandPNGBDBM92647(EPZ003696)
Affinity DataKi:  13nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM92642(SAH)
Affinity DataKi:  320nM Kd:  71nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM92646(EPZ003647)
Affinity DataKi:  845nM Kd:  167nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM92644(EPZ002446)
Affinity DataKi:  1.20E+4nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM92645(EPZ003144)
Affinity DataKi:  2.00E+4nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM92643(EPZ000004)
Affinity DataKi:  3.80E+4nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362985(CHEMBL1945502)
Affinity DataIC50:  1nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378446(N-((1R,3r,5S)-8-((4-aminopiperidin-1-yl)sulfonyl)-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378445(N-((1R,3r,5S)-8-((4-aminopiperidin-1-yl)sulfonyl)-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378444(N-((1R,3r,5S)-8-(((1-methylpiperidin-4-yl)methyl)s...)
Affinity DataIC50:  1nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378453(6-chloro-N-((1R,3r,5S)-8-((4-(methylamino)piperidi...)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378452(6-chloro-N-((1R,3r,5S)-8-(((1-(3-hydroxypropyl)pip...)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378462(6-chloro-2-oxo-N-((1R,3r,5S)-8-(((1-(4,4,4-trifluo...)
Affinity DataIC50:  3nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378461(6-chloro-N-((1R,3r,5S)-8-((4-(dimethylamino)piperi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378463(6-chloro-2-oxo-N-((1R,3r,5S)-8-((piperidin-4-ylmet...)
Affinity DataIC50:  4nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50500875(CHEMBL3798745)
Affinity DataIC50:  4nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378459(N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)su...)
Affinity DataIC50:  4nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378464(2-oxo-N-((1R,3r,5S)-8-((piperidin-4-ylmethyl)sulfo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378442(N-((1R,3R,5S)-8-(((1r,4R)-4-aminocyclohexyl)sulfon...)
Affinity DataIC50:  4nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50500876(CHEMBL3797575)
Affinity DataIC50:  5nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362988(CHEMBL1945500)
Affinity DataIC50:  5nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362985(CHEMBL1945502)
Affinity DataIC50:  5nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378443(N-((1R,3r,5S)-8-((4-aminopiperidin-1-yl)sulfonyl)-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362986(CHEMBL1945501)
Affinity DataIC50:  7nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362984(CHEMBL1945801)
Affinity DataIC50:  9nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362981(CHEMBL1945171)
Affinity DataIC50:  10nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362982(CHEMBL1945170)
Affinity DataIC50:  10nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362976(CHEMBL1945803)
Affinity DataIC50:  11nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362976(CHEMBL1945803)
Affinity DataIC50:  11nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362982(CHEMBL1945170)
Affinity DataIC50:  12nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362982(CHEMBL1945170)
Affinity DataIC50:  12nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378473(N-((1R,3r,5S)-8-((4-aminopiperidin-1-yl)sulfonyl)-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362981(CHEMBL1945171)
Affinity DataIC50:  18nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362982(CHEMBL1945170)
Affinity DataIC50:  19nMAssay Description:Inhibition of PDGFRbMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362976(CHEMBL1945803)
Affinity DataIC50:  20nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362986(CHEMBL1945501)
Affinity DataIC50:  21nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362986(CHEMBL1945501)
Affinity DataIC50:  23nMAssay Description:Inhibition of PDGFRbMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378478(1-methyl-2-oxo-N-((1R,3r,5S)-8-((piperidin-4-ylmet...)
Affinity DataIC50:  26nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362976(CHEMBL1945803)
Affinity DataIC50:  27nMAssay Description:Inhibition of PDGFRbMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362985(CHEMBL1945502)
Affinity DataIC50:  27nMAssay Description:Inhibition of PDGFRbMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362982(CHEMBL1945170)
Affinity DataIC50:  28nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50362976(CHEMBL1945803)
Affinity DataIC50:  31nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378462(6-chloro-2-oxo-N-((1R,3r,5S)-8-(((1-(4,4,4-trifluo...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human SMYD3 expressed in HEK293T/17 cells using FLAG-tagged MEKK2 as substrate incubated for 30 mins in low air flow area followed by i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378459(N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)su...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human SMYD3 expressed in HEK293T/17 cells using FLAG-tagged MEKK2 as substrate incubated for 30 mins in low air flow area followed by i...More data for this Ligand-Target Pair
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