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Found 178 with Last Name = 'seitz' and Initial = 'w'
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122205((R)-4-{4-[3-(1H-Benzoimidazol-2-ylamino)-propylami...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122205((R)-4-{4-[3-(1H-Benzoimidazol-2-ylamino)-propylami...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50372236(CHEMBL256672)
Affinity DataIC50:  0.700nMAssay Description:Displacement of vitronectin from integrin alphavbeta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50114263(((R)-2-{(S)-2-[(5-Carbamimidoyl-thiophen-2-ylmethy...)
Affinity DataIC50:  0.980nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122204((S)-3-{4-[4-(1H-Benzoimidazol-2-ylamino)-piperidin...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50182198(((R)-2-{(S)-2-[(5-carbamimidoyl-thiophen-2-ylmethy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of thrombin by chromogenic assayMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50114263(((R)-2-{(S)-2-[(5-Carbamimidoyl-thiophen-2-ylmethy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of thrombin by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122219((R)-4-{4-[4-(1H-Benzoimidazol-2-ylamino)-piperidin...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50182201(((R)-2-{(S)-2-[(6-carbamimidoyl-pyridin-3-ylmethyl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50183865(((R)-2-{(S)-2-[(4-carbamimidoyl-furan-2-ylmethyl)-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122192((S)-3-(4-{4-[(1H-Benzoimidazol-2-ylamino)-methyl]-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of alphaIIb-beta3 integrin binding to fibrinogen in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122198((S)-3-(4-{4-[(1H-Benzoimidazol-2-ylamino)-methyl]-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50183877(((R)-2-{(S)-2-[(4-carbamimidoyl-thiazol-2-ylmethyl...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122227((S)-3-(4-{4-[(1H-Benzoimidazol-2-ylamino)-methyl]-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122195((S)-3-(4-{4-[(1H-Benzoimidazol-2-ylamino)-methyl]-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50411639(CHEMBL269950)
Affinity DataIC50:  1.5nMAssay Description:Displacement of vitronectin from integrin alphavbeta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50109298(CHEMBL344162 | [5-({[4-(1H-Benzoimidazol-2-ylamino...)
Affinity DataIC50:  1.60nMAssay Description:Affinity against alpha V-beta3 integrin via competitive ELISA using vitronectin as natural ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50182194(CHEMBL206418 | {(R)-2-[(S)-2-(4-carbamimidoyl-benz...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of thrombin by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50182196(((R)-2-{(S)-5-[(6-carbamimidoyl-pyridin-3-ylmethyl...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of thrombin by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50182194(CHEMBL206418 | {(R)-2-[(S)-2-(4-carbamimidoyl-benz...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50182201(((R)-2-{(S)-2-[(6-carbamimidoyl-pyridin-3-ylmethyl...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of thrombin by chromogenic assayMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50183868(((R)-2-{(S)-2-[(5-carbamimidoyl-4-methyl-thiophen-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50183870(((R)-2-{(S)-2-[(4-carbamimidoyl-3-chloro-thiophen-...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122225((S)-2-Benzyloxycarbonylamino-3-{5-methyl-2-oxo-4-[...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50183879(((R)-2-{(S)-2-[(4-carbamimidoyl-thiophen-2-ylmethy...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50182189(CHEMBL207187 | {(R)-2-[(S)-2-(4-carbamimidoyl-benz...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of thrombin by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122222((R)-3-Benzyloxycarbonylamino-4-{4-[3-(1H-imidazol-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50182210(((R)-2-{(S)-2-[(6-carbamimidoyl-pyridin-3-ylmethyl...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of thrombin by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50182197(((R)-2-{(S)-5-[(6-carbamimidoyl-pyridin-3-ylmethyl...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of thrombin by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122216((R)-3-Benzyloxycarbonylamino-4-{4-[2-(1H-imidazol-...)
Affinity DataIC50:  3.60nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122228((S)-2-Benzyloxycarbonylamino-3-(4-{[2-(3-benzyl-ur...)
Affinity DataIC50:  4.20nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50372237(CHEMBL256673)
Affinity DataIC50:  4.20nMAssay Description:Displacement of vitronectin from integrin alphavbeta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50183872(((R)-2-{(S)-2-[(5-carbamimidoyl-4-chloro-thiophen-...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50411638(CHEMBL404371)
Affinity DataIC50:  4.40nMAssay Description:Displacement of vitronectin from integrin alphavbeta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50129034(((R)-2-{(S)-2-[(5-Carbamimidoyl-1H-pyrrol-2-ylmeth...)
Affinity DataIC50:  6.20nMAssay Description:In vitro inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50129034(((R)-2-{(S)-2-[(5-Carbamimidoyl-1H-pyrrol-2-ylmeth...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50183880(((R)-2-{(S)-2-[(5-carbamimidoyl-thiophen-3-ylmethy...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50109296((5-{[4-(1H-Benzoimidazol-2-ylamino)-benzylcarbamoy...)
Affinity DataIC50:  7nMAssay Description:Affinity against alpha V-beta3 integrin via competitive ELISA using vitronectin as natural ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50109296((5-{[4-(1H-Benzoimidazol-2-ylamino)-benzylcarbamoy...)
Affinity DataIC50:  7.30nMAssay Description:Affinity against alpha V-beta3 integrin via competitive ELISA using vitronectin as natural ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50411637(CHEMBL255952)
Affinity DataIC50:  7.40nMAssay Description:Displacement of vitronectin from integrin alphavbeta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122218((S)-3-{4-[4-(1H-Benzoimidazol-2-yl)-piperidin-1-yl...)
Affinity DataIC50:  9.40nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50183878(((R)-2-{(S)-2-[(4-carbamimidoyl-3-methyl-thiophen-...)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50411631(CHEMBL258325)
Affinity DataIC50:  10nMAssay Description:Displacement of vitronectin from integrin alphavbeta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122198((S)-3-(4-{4-[(1H-Benzoimidazol-2-ylamino)-methyl]-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122202((S)-2-Benzyloxycarbonylamino-3-{5-methyl-2-oxo-4-[...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50122220((R)-4-(4-{4-[2-(1H-Benzoimidazol-2-ylamino)-ethyl]...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50411627(CHEMBL269961)
Affinity DataIC50:  11nMAssay Description:Displacement of vitronectin from integrin alphavbeta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Basf

Curated by ChEMBL
LigandPNGBDBM29388(Exanta | Melagatran | US11584714, Compound 999)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory activity against trypsinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50129033(((R)-2-{(S)-2-[(5-Carbamimidoyl-1-methyl-1H-pyrrol...)
Affinity DataIC50:  11nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50129033(((R)-2-{(S)-2-[(5-Carbamimidoyl-1-methyl-1H-pyrrol...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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