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Found 2456 with Last Name = 'showalter' and Initial = 'h'
TargetAdenosine deaminase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM22925((8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxol...)
Affinity DataKi:  0.00250nMAssay Description:The compound was tested in vitro for inhibition of human erythrocytic adenosine deaminase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAdenosine deaminase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.0100nMAssay Description:The compound was tested in vitro for inhibition of human erythrocytic adenosine deaminaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target6-phosphogluconate dehydrogenase, decarboxylating(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50148767(2,3-dihydroxy-4-(hydroxyamino)-4-oxobutyl dihydrog...)
Affinity DataKi:  10nMAssay Description:Inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50028153(3-(4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl...)
Affinity DataKi:  16nMAssay Description:In vitro inhibition of adenosine deaminase in calf intestinal mucosaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target6-phosphogluconate dehydrogenase, decarboxylating(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50148780(((4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dio...)
Affinity DataKi:  35nMAssay Description:Inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target6-phosphogluconate dehydrogenase, decarboxylating(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50148765(1-(hydroxyamino)-1-oxo-4-(phosphonooxy)butane-2,3-...)
Affinity DataKi:  80nMAssay Description:Inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50028156(3-(2-Hydroxy-ethoxymethyl)-3,6,7,8-tetrahydro-imid...)
Affinity DataKi:  98nMAssay Description:In vitro inhibition of adenosine deaminase in calf intestinal mucosaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate isomerase(Oryctolagus cuniculus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50342610((2R,3R,4S)-2,3,4-trihydroxy-5-(hydroxyamino)-5-oxo...)
Affinity DataKi:  100nMAssay Description:Inhibition of rabbit cytosolic phosphoglucose isomeraseMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50450976(CHEMBL4210672)
Affinity DataKi:  123nMAssay Description:Antagonist activity at human alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as reduction in acetylcholine-induced peak current at -60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238185(US9394303, 57)
Affinity DataKi:  130nM ΔG°:  -39.3kJ/mole IC50:  670nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013865(CHEMBL3265297)
Affinity DataKi:  170nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013867(CHEMBL3265299)
Affinity DataKi:  180nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238190(US9394303, 16)
Affinity DataKi:  210nM ΔG°:  -38.1kJ/mole IC50:  1.11E+3nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013891(CHEMBL3260032)
Affinity DataKi:  210nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013866(CHEMBL3265298)
Affinity DataKi:  240nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238186(US9394303, 58)
Affinity DataKi:  250nM ΔG°:  -37.7kJ/mole IC50:  1.28E+3nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238181(US9394303, 8)
Affinity DataKi:  290nM ΔG°:  -37.3kJ/mole IC50:  1.52E+3nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013868(CHEMBL3265300)
Affinity DataKi:  290nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target6-phosphogluconate dehydrogenase, decarboxylating(Ovis aries)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50148765(1-(hydroxyamino)-1-oxo-4-(phosphonooxy)butane-2,3-...)
Affinity DataKi:  360nMAssay Description:Inhibition of sheep 6-phosphogluconate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013862(CHEMBL3265294)
Affinity DataKi:  370nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013863(CHEMBL3265295)
Affinity DataKi:  380nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238192(US9394303, 18)
Affinity DataKi:  490nM ΔG°:  -36.0kJ/mole IC50:  2.54E+3nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM53290(2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynapht...)
Affinity DataKi:  490nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013838(CHEMBL3260042)
Affinity DataKi:  550nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013861(CHEMBL3235895)
Affinity DataKi:  730nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013845(CHEMBL3265290)
Affinity DataKi:  810nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238187(US9394303, 59)
Affinity DataKi:  820nM ΔG°:  -34.7kJ/mole IC50:  4.27E+3nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM53262(2-[4-[(4-chlorophenyl)sulfonylamino]-1-hydroxynaph...)
Affinity DataKi:  820nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238196(US9394303, 62)
Affinity DataKi:  880nM ΔG°:  -34.6kJ/mole IC50:  4.51E+3nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238184(US9394303, 56)
Affinity DataKi:  900nM ΔG°:  -34.5kJ/mole IC50:  4.68E+3nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013882(CHEMBL3265313)
Affinity DataKi:  1.01E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013844(CHEMBL3235886)
Affinity DataKi:  1.06E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013865(CHEMBL3265297)
Affinity DataKi:  1.11E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged A1-BFL-1 (1 to 151) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013883(CHEMBL3260033)
Affinity DataKi:  1.13E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238191(US9394303, 17)
Affinity DataKi:  1.21E+3nM ΔG°:  -33.8kJ/mole IC50:  6.30E+3nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238195(US9394303, 61)
Affinity DataKi:  1.30E+3nM ΔG°:  -33.6kJ/mole IC50:  6.76E+3nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBcl-2-like protein 2(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013865(CHEMBL3265297)
Affinity DataKi:  1.36E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged BCLW (1 to 155) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238182(US9394303, 9)
Affinity DataKi:  1.40E+3nM ΔG°:  -33.4kJ/mole IC50:  7.30E+3nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238180(US9394303, 7)
Affinity DataKi:  1.40E+3nM ΔG°:  -33.4kJ/mole IC50:  7.30E+3nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine deaminase(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50028152(5-Ethyl-3-(4-hydroxy-5-hydroxymethyl-tetrahydro-fu...)
Affinity DataKi:  1.50E+3nMAssay Description:In vitro inhibition of adenosine deaminase in calf intestinal mucosaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target6-phosphogluconate dehydrogenase, decarboxylating(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50148769((R)-Phosphoric acid mono-((R)-3-carbamoyl-2,3-dihy...)
Affinity DataKi:  1.52E+3nMAssay Description:Inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238194(US9394303, 60)
Affinity DataKi:  1.53E+3nM ΔG°:  -33.2kJ/mole IC50:  7.97E+3nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013860(CHEMBL3265293)
Affinity DataKi:  1.54E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013839(CHEMBL2030270)
Affinity DataKi:  1.55E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM52608(2-[4-[(4-ethylphenyl)sulfonylamino]-1-hydroxynapht...)
Affinity DataKi:  1.55E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 2(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013867(CHEMBL3265299)
Affinity DataKi:  1.58E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged BCLW (1 to 155) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013879(CHEMBL3265310)
Affinity DataKi:  1.71E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 2(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013862(CHEMBL3265294)
Affinity DataKi:  1.92E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged BCLW (1 to 155) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM238185(US9394303, 57)
Affinity DataKi:  1.95E+3nM ΔG°:  -32.6kJ/molepH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50013864(CHEMBL3265296)
Affinity DataKi:  2.03E+3nMAssay Description:Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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