Target
Apoptosis regulator Bcl-2
Ligand
BDBM238185
Substrate
n/a
Meas. Tech.
Fluorescence Polarization-Based Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
1950±200 nM
Comments
extracted
Citation
 Nikolovska-Coleska, ZAbulwerdi, FShowalter, HMiao, LStuckey, JMady, A Small molecule inhibitors of MCL-1 and uses thereof US Patent  US9394303 Publication Date 7/19/2016 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
BCL2_MOUSE | Bcl-2 | Bcl2
Type:
Protein
Mol. Mass.:
26409.44
Organism:
Mus musculus (Mouse)
Description:
P10417
Residue:
236
Sequence:
MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPAVHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM238185
Synonyms:
US9394303, 57
Type:
Small organic molecule
Emp. Form.:
C27H22ClN3O4
Mol. Mass.:
487.934
SMILES:
Cc1nn(Cc2ccc(Oc3cc(C)c(Cl)c(C)c3)cc2)c2nc(cc(C(O)=O)c12)-c1ccco1
Structure:
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