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Found 44 with Last Name = 'siani' and Initial = 'ma'
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.200nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50039664(CHEMBL91890 | N-Biphenyl-4-yl-N-[(carbamoylmethyl-...)
Affinity DataKi:  4nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  4nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPromotilin(Homo sapiens (Human))
Kosan Biosciences

Curated by PDSP Ki Database
LigandPNGBDBM85389(CAS_52906-92-0 | Motilin)
Affinity DataKi:  5.25nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50039665(CHEMBL90649 | CHIR-4531 | N-Benzo[1,3]dioxol-5-ylm...)
Affinity DataKi:  6nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from rat brain membrane using [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPromotilin(Homo sapiens (Human))
Kosan Biosciences

Curated by PDSP Ki Database
LigandPNGBDBM85846(CAS_33396-29-1 | EM523 | Erythromycin A 6,9-enolet...)
Affinity DataKi:  19.1nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50019056((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  20nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50039661(CHEMBL327549 | CHIR-4537 | N-({Carbamoylmethyl-[2-...)
Affinity DataKi:  31nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from rat brain membrane using [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50039663(CHEMBL89378 | CHIR-4534 | N-({Carbamoylmethyl-[2-(...)
Affinity DataKi:  46nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from rat brain membrane using [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPromotilin(Homo sapiens (Human))
Kosan Biosciences

Curated by PDSP Ki Database
LigandPNGBDBM85846(CAS_33396-29-1 | EM523 | Erythromycin A 6,9-enolet...)
Affinity DataKi:  47.9nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPromotilin(Homo sapiens (Human))
Kosan Biosciences

Curated by PDSP Ki Database
LigandPNGBDBM50127141((3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2R,3S,4R,...)
Affinity DataKi:  1.29E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50029050((-)-(R)-epinephrine | (-)-3,4-dihydroxy-alpha-((me...)
Affinity DataKi:  4.00E+3nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Chiron

Curated by ChEMBL
LigandPNGBDBM50029051((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Affinity DataKi:  1.40E+4nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126395(Ac-Ser-Tyr-Ser-Nle-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro...)
Affinity DataIC50:  15nMAssay Description:Binding affinity of the compound against human melanocortin 4 receptor (hMC4R) using [125I]- agouti related protein (AGRP) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126395(Ac-Ser-Tyr-Ser-Nle-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity of the compound against hMC3R (human melanocortin receptor) using I-AGRP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126395(Ac-Ser-Tyr-Ser-Nle-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro...)
Affinity DataIC50:  19nMAssay Description:Binding affinity of the compound against human melanocortin 4 receptor (hMC4R) using [125I]- NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM32628(FTC | Fumitremorgin C)
Affinity DataIC50:  800nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126393(CHEMBL417853 | N-Benzhydryl-N-{[carbamoylmethyl-((...)
Affinity DataIC50:  1.90E+3nMAssay Description:Binding affinity of the compound against human melanocortin 4 receptor (hMC4R) using [125I]- agouti related protein (AGRP) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126393(CHEMBL417853 | N-Benzhydryl-N-{[carbamoylmethyl-((...)
Affinity DataIC50:  1.90E+3nMAssay Description:Binding affinity of the compound against human melanocortin 4 receptor (hMC4R) using [125I]- ([Nle4]alpha-MSH) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126393(CHEMBL417853 | N-Benzhydryl-N-{[carbamoylmethyl-((...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory activity of the compound against hMC4R (human melanocortin receptor) using I-AGRP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126393(CHEMBL417853 | N-Benzhydryl-N-{[carbamoylmethyl-((...)
Affinity DataIC50:  3.10E+3nMAssay Description:Binding affinity of the compound against human melanocortin 4 receptor (hMC4R) using [125I]- ([Nle4]alpha-MSH) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM19460((2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126393(CHEMBL417853 | N-Benzhydryl-N-{[carbamoylmethyl-((...)
Affinity DataIC50:  3.10E+3nMAssay Description:Binding affinity of the compound against human melanocortin 4 receptor (hMC4R) using [125I]- ([Nle4]alpha-MSH) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50339152((S)-2-(3,5-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50339155(6-(3,7-dimethylocta-2,6-dienyl)-3,5,7-trihydroxy-2...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50064888(3',5-dihydroxy-3,4',7-trimethoxyflavone | 5-hydrox...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50339159(5-Hydroxy-3-(4-hydroxy-3-methyl-but-2-enyl)-8,8-di...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50339151((2S)-5,7,3'-trihydroxy-4'-methoxy-8-(3''-methylbut...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50339158(5,7,3'-trihydroxy-3,5'-dimethoxy-2'-(3'-methylbut-...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126393(CHEMBL417853 | N-Benzhydryl-N-{[carbamoylmethyl-((...)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibitory activity of the compound against hMC1R (human melanocortin receptor) using [125I]-[Nle4] alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50339156((S)-8-(3,7-dimethylocta-2,6-dienyl)-5,7-dihydroxy-...)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50339153((2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethyloct...)
Affinity DataIC50:  1.55E+4nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50339157(5,4'-dihydroxy-3,7,3'-trimethoxyflavone | 5-Hydrox...)
Affinity DataIC50:  1.72E+4nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50339154((2S)-5,7-dihydroxy-4'-methoxy-8-prenylflavanone | ...)
Affinity DataIC50:  2.26E+4nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126393(CHEMBL417853 | N-Benzhydryl-N-{[carbamoylmethyl-((...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibitory activity of the compound against hMC1R (human melanocortin receptor) using [125I]- ASIP Y radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126393(CHEMBL417853 | N-Benzhydryl-N-{[carbamoylmethyl-((...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibitory activity of the compound against hMC3R (human melanocortin receptor) using [125I]-[Nle4] alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126393(CHEMBL417853 | N-Benzhydryl-N-{[carbamoylmethyl-((...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory activity of the compound against hMC4R (human melanocortin receptor) using [125I]-[Nle4] alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126397(2-[Benzyl-(2-{[2-(3-guanidino-propylamino)-acetyl]...)
Affinity DataIC50: >1.00E+5nMAssay Description:Binding affinity of the compound against human melanocortin 4 receptor (hMC4R) using [125I]- ([Nle4]alpha-MSH) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126394(CHEMBL440102 | N-Benzyl-N-[(benzyl-carbamoylmethyl...)
Affinity DataIC50: >1.00E+5nMAssay Description:Binding affinity of the compound against human melanocortin 4 receptor (hMC4R) using [125I]- agouti related protein (AGRP) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126394(CHEMBL440102 | N-Benzyl-N-[(benzyl-carbamoylmethyl...)
Affinity DataIC50: >1.00E+5nMAssay Description:Binding affinity of the compound against human melanocortin 4 receptor (hMC4R) using [125I]- ([Nle4]alpha-MSH) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126396(CHEMBL30677 | N-Benzyl-N-{[carbamoylmethyl-((R)-1-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Binding affinity of the compound against human melanocortin 4 receptor (hMC4R) using [125I]- agouti related protein (AGRP) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50126396(CHEMBL30677 | N-Benzyl-N-{[carbamoylmethyl-((R)-1-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Binding affinity of the compound against human melanocortin 4 receptor (hMC4R) using [125I]- NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed