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Found 71 with Last Name = 'sigel' and Initial = 'e'
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
X-Chem Pharmaceuticals

LigandPNGBDBM225238(BTK inhibitor, 3)
Affinity DataIC50:  0.550nMT: 2°CAssay Description:The BTK time-resolved FRET-based competitive binding assay and cell-based BTK assays have been previously described.[Xu et al., J.Pharmacol. Exp. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Google Research Applied Science, Mountain View, California 94043, United States.

Curated by ChEMBL
LigandPNGBDBM50559893(CHEMBL4749356)
Affinity DataIC50:  1nMAssay Description:Inhibition of His-tagged human recombinant soluble epoxide hydrolase pre-incubated for 15 mins before Epoxy-fluor7 substrate addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540028(CHEMBL4635769)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Google Research Applied Science, Mountain View, California 94043, United States.

Curated by ChEMBL
LigandPNGBDBM50559894(CHEMBL4793243)
Affinity DataIC50:  2nMAssay Description:Inhibition of His-tagged human recombinant soluble epoxide hydrolase pre-incubated for 15 mins before Epoxy-fluor7 substrate addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540030(CHEMBL4633392)
Affinity DataIC50:  2nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540025(CHEMBL4639517)
Affinity DataIC50:  2nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540029(CHEMBL4648587)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540026(CHEMBL4645846)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  7nMAssay Description:Inhibition of autotaxin in mouse plasma assessed as reduction in LPA (18:2) production incubated for 2 hrs LC-MS-/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Google Research Applied Science, Mountain View, California 94043, United States.

Curated by ChEMBL
LigandPNGBDBM50559895(CHEMBL4763747)
Affinity DataIC50:  8nMAssay Description:Inhibition of His-tagged human ERalpha pre-incubated for 15 mins before fluorescent ligand addition and measured after 1 hr by fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Google Research Applied Science, Mountain View, California 94043, United States.

Curated by ChEMBL
LigandPNGBDBM50559898(CHEMBL4752670)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant c-Kit (unknown origin) incubated for 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM370043((R)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-4-oxo-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  14nMAssay Description:Inhibition of autotaxin in human plasma assessed as reduction in LPA (18:2) production incubated for 2 hrs LC-MS-/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Google Research Applied Science, Mountain View, California 94043, United States.

Curated by ChEMBL
LigandPNGBDBM50559896(CHEMBL4750790)
Affinity DataIC50:  20nMAssay Description:Inhibition of His-tagged human ERalpha pre-incubated for 15 mins before fluorescent ligand addition and measured after 1 hr by fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Google Research Applied Science, Mountain View, California 94043, United States.

Curated by ChEMBL
LigandPNGBDBM50559897(CHEMBL4800276)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant c-Kit (unknown origin) incubated for 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM370050((R)-4-(8-(2-(2-Fluoro-5-(trifluoromethyl)benzamido...)
Affinity DataIC50:  31nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369944((R)—N-(2-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  34nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM370016((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-2,4-dioxo-1-p...)
Affinity DataIC50:  38nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM370019((R)—N-(1-(1-(3-Chlorophenyl)-3-methyl-2,4-dio...)
Affinity DataIC50:  46nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  55nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540028(CHEMBL4635769)
Affinity DataIC50:  56nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540025(CHEMBL4639517)
Affinity DataIC50:  86nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369934((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-2,4-dioxo-1-p...)
Affinity DataIC50:  100nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
X-Chem Pharmaceuticals

LigandPNGBDBM225237(BTK inhibitor, 2)
Affinity DataIC50:  210nMT: 2°CAssay Description:The BTK time-resolved FRET-based competitive binding assay and cell-based BTK assays have been previously described.[Xu et al., J.Pharmacol. Exp. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369946(US10233182, Example 59)
Affinity DataIC50:  340nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540027(CHEMBL4638762)
Affinity DataIC50:  350nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369899((R)-3-Methyl-N-(2-(3-methyl-4-oxo-1-phenyl-1,3,8-t...)
Affinity DataIC50:  623nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369876((R)-2-Fluoro-3-methyl-N-(3-methyl-1-(3-methyl-2,4-...)
Affinity DataIC50:  683nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540031(CHEMBL4646195)
Affinity DataIC50:  819nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540032(CHEMBL4636626)
Affinity DataIC50:  905nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369827((R)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
X-Chem Pharmaceuticals

LigandPNGBDBM225236(BTK inhibitor, 1)
Affinity DataIC50:  2.50E+3nMT: 2°CAssay Description:The BTK time-resolved FRET-based competitive binding assay and cell-based BTK assays have been previously described.[Xu et al., J.Pharmacol. Exp. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369824((R)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369829(N-(2-(1-(1H-Indazol-5-yl)-3-methyl-2,4-dioxo-1,3,8...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LPAR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 3(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LPAR3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ENPP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 2(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LPAR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369828((S)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369852((S)-3-Methyl-N-(2-(3-methyl-4-oxo-1-phenyl-1,3,8-t...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human ERG by manual patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human ERG by GLP based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase(Escherichia coli (Enterobacteria))
X-Biotix Therapeutics

Curated by ChEMBL
LigandPNGBDBM50577526(CHEMBL4871671)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant Escherichia coli LpxA using UDP-GlcNAc as substrate incubated for 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50508950(CHEMBL4472439)
Affinity DataKd:  120nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50508948(CHEMBL4473598)
Affinity DataKd:  20nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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