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Found 50 with Last Name = 'simon' and Initial = 'rp'
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataKi:  400nMAssay Description:Inhibition of synthetic VMA-tagged p300 (1287 to 1652 residues) (unknown origin) expressed in Escherichia coli BL21(RIL)-DE3 cells using H4-15 peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human recombinant C-terminal GST-tagged p300 (1195 to 1673 residues) expressed in competent Escherichia coli DH5alpha cells using histo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151655(CHEMBL3774787)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant C-terminal GST-tagged p300 (1195 to 1673 residues) expressed in competent Escherichia coli DH5alpha cells using histo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151656(CHEMBL3774491)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant C-terminal GST-tagged p300 (1195 to 1673 residues) expressed in competent Escherichia coli DH5alpha cells using histo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant full length p300 (unknown origin) using N-terminal H4-20 peptide substrate incubated for 7 mins by radiometric gel assay in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151651(CHEMBL3775655)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant p300 catalytic domain (1284 to 1673 residues) expressed in Escherichia coli using H4-8 peptide substrate by radiometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151650(CHEMBL3775229)
Affinity DataIC50:  300nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PCAF expressed in baculovirus expression system using histone substrate incubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  500nMAssay Description:Inhibition of full length recombinant human FLAG-tagged p300 expressed in baculovirus expression system using histone substrate incubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of synthetic VMA-tagged p300 (1287 to 1652 residues) (unknown origin) expressed in Escherichia coli BL21(RIL)-DE3 cells using H4-15 peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151658(CHEMBL3775671)
Affinity DataIC50:  1.98E+3nMAssay Description:Inhibition of recombinant p300 catalytic domain (unknown origin) using N-terminal histone H3 substrate by orthogonal fluorescence assay in presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50012070(5-Hydroxy-2-methyl-[1,4]naphthoquinone | 5-hydroxy...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant His6-tagged p300 catalytic domain (1284 to1673 residues) (unknown origin) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT5(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151660(CHEMBL3774630)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant N-terminal His-tagged TIP60 (unknown origin) expressed in baculovirus-infected insect cell system using histone substrate i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50240436(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
Affinity DataIC50:  4.15E+3nMAssay Description:Inhibition of recombinant p300 catalytic domain (unknown origin) using N-terminal histone H3 substrate by radiometric filter binding assay in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50443249(Ischemin)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of p53-CBP bromodomain interaction in human U2OS cells assessed as inhibition of p21 activation incubated overnight followed by doxorubici...More data for this Ligand-Target Pair
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50240436(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PCAF expressed in baculovirus infected Sf21 cells using N-terminal H3 peptide substrate after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151654(CHEMBL3775787)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of full length recombinant His6-tagged p300 (unknown origin) expressed in baculovirus infected sf21 cells using histone substrate after 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151653(CHEMBL3774884)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PCAF expressed in baculovirus infected Sf21 cells using N-terminal H3 peptide substrate after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of recombinant human p300 catalytic domain (1284 to 1673 residues) using histone H3 peptide substrate after 1 hr by liquid scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151653(CHEMBL3774884)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged p300 expressed in baculovirus infected Sf21 cells using N-terminal H3 peptide substrate after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50078850(CHEBI:4778 | Embelin)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of full length recombinant FLAG-tagged PCAF (unknown origin) expressed in baculovirus expression system using histone substrate after 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50240436(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged p300 expressed in baculovirus infected Sf21 cells using N-terminal H3 peptide substrate after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of FLAG-tagged p300 (1195 to 1673 residues) (unknown origin) expressed in competent Escherichia coli BL21-CodonPlus(DE3)-RIL cells using h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50012070(5-Hydroxy-2-methyl-[1,4]naphthoquinone | 5-hydroxy...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of full length recombinant His6-tagged p300 (unknown origin) expressed in baculovirus expression system using histone substrate after 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of recombinant p300 (unknown origin) expressed in baculovirus expression system using histone substrate after 10 mins by liquid scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of recombinant CBP (unknown origin) expressed in baculovirus expression system using histone substrate after 10 mins by liquid scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of recombinant GST-tagged p300 (unknown origin) using histone H4 peptide substrate assessed as reduction in NADH formation by spectrophoto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2A(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151658(CHEMBL3775671)
Affinity DataIC50:  3.39E+4nMAssay Description:Inhibition of GCN5 (unknown origin) using N-terminal histone H3 substrate by radiometric filter binding based phenotypic screen in presence of [3H]ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50240436(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
Affinity DataIC50:  3.39E+4nMAssay Description:Inhibition of recombinant human PCAF catalytic domain (492 to 658 residues) using histone H3 peptide substrate after 1 hr by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151658(CHEMBL3775671)
Affinity DataIC50:  3.47E+4nMAssay Description:Inhibition of PCAF (unknown origin) using N-terminal histone H3 substrate by radiometric filter binding based phenotypic screen in presence of [3H]ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151660(CHEMBL3774630)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of recombinant GST-tagged PCAF (unknown origin) expressed in Escherichia coli cells using histone substrate incubated for 10 mins by radio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of recombinant GST-tagged CBP (unknown origin) using histone H4 peptide substrate assessed as reduction in NADH formation by spectrophotom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50012070(5-Hydroxy-2-methyl-[1,4]naphthoquinone | 5-hydroxy...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of recombinant PCAF (unknown origin) expressed in baculovirus expression system using histone substrate after 10 mins by liquid scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151660(CHEMBL3774630)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibition of recombinant GST-tagged p300 (unknown origin) expressed in Escherichia coli cells using histone substrate incubated for 10 mins by radio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of recombinant PCAF (unknown origin) using histone H4 peptide substrate assessed as reduction in NADH formation by spectrophotometric anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT5(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of recombinant TIP60 (unknown origin) using histone H4 peptide substrate assessed as reduction in NADH formation by spectrophotometric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2A(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151657(CHEMBL3775750)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged GCN5 expressed in bacterial system using histone H3 as substrate preincubated for 20 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151659(CHEMBL3775244)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PCAF (unknown origin) using N-terminal histone H3-20 peptide substrate incubated for 3.5 mins by liquid scintillation counting method i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151658(CHEMBL3775671)
Affinity DataIC50:  1.28E+5nMAssay Description:Inhibition of recombinant p300 catalytic domain (unknown origin) using N-terminal histone H3 substrate by radiometric filter binding based phenotypic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT5(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151659(CHEMBL3775244)
Affinity DataIC50:  1.49E+5nMAssay Description:Inhibition of full length TIP60 (unknown origin) expressed in Escherichia coli using N-terminal histone H4-20 peptide substrate incubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151659(CHEMBL3775244)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of p300 (unknown origin) using N-terminal histone H4-20 peptide substrate incubated for 10 mins by liquid scintillation counting method in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpermidine synthase(Sus scrofa)
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151659(CHEMBL3775244)
Affinity DataIC50:  1.90E+5nMAssay Description:Inhibition of yeast ESA1 using N-terminal histone H3 substrate by radiometric filter binding based virtual screen in presence of [3H]acetyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PCAF expressed in baculovirus expression system using histone substrate incubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151650(CHEMBL3775229)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of full length recombinant human FLAG-tagged p300 expressed in baculovirus expression system using histone substrate incubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151652(CHEMBL3774466)
Affinity DataIC50:  2.75E+5nMAssay Description:Inhibition of full length recombinant human His6-tagged p300 expressed in baculovirus infected Sf21 cells using N-terminal H3 peptide substrate after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151657(CHEMBL3775750)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of recombinant CBP (unknown origin) expressed in baculovirus expression system using histone H3 as substrate preincubated for 20 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataKd:  151nMAssay Description:Inhibition of human CREBBP expressed in competent escherichia coli BL21(DE3)-R3-pRARE2 cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151662(CHEMBL3775371)
Affinity DataKd:  21nMAssay Description:Inhibition of human CREBBP expressed in competent escherichia coli BL21(DE3)-R3-pRARE2 cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151661(CHEMBL3752296)
Affinity DataKd:  1.40E+3nMAssay Description:Inhibition of human BRD4 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151661(CHEMBL3752296)
Affinity DataKd:  390nMAssay Description:Inhibition of human His6-tagged CREBBP expressed in competent Escherichia coli BL21 (DE3) cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataKd:  167nMAssay Description:Inhibition of human p300 expressed in competent escherichia coli BL21(DE3)-R3-pRARE2 cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed