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Found 126 with Last Name = 'simonnet' and Initial = 'y'
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598905(CHEMBL5180161)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598917(CHEMBL5171223)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598902(CHEMBL5187184)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50:  0.550nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50:  0.550nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163613((2,3-Dihydro-1H-cyclopenta[b]quinolin-7-yl)-(4-met...)
Affinity DataIC50:  0.560nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598922(CHEMBL5186161)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598915(CHEMBL5198030)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598926(CHEMBL5206111)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163596((2-Amino-3-ethyl-quinolin-6-yl)-(4-methoxy-cyclohe...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598913(CHEMBL5193591)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598920(CHEMBL5209113)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM470454(N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxym...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598914(CHEMBL5197263)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163617((2,3-Dihydro-thieno[2,3-b]quinolin-6-yl)-(4-methox...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163617((2,3-Dihydro-thieno[2,3-b]quinolin-6-yl)-(4-methox...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598919(CHEMBL5176109)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598916(CHEMBL5205042)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598918(CHEMBL5207423)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598910(CHEMBL5197809)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163590((2,3-Diethyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163590((2,3-Diethyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163589((4-Methoxy-cyclohexyl)-(2-propyl-quinolin-6-yl)-me...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163607(3-ethyl-6-[(4-methoxycyclohexyl)carbonyl]quinoline...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163613((2,3-Dihydro-1H-cyclopenta[b]quinolin-7-yl)-(4-met...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163616((2-Chloro-3-ethyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598908(CHEMBL5193091)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163616((2-Chloro-3-ethyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163589((4-Methoxy-cyclohexyl)-(2-propyl-quinolin-6-yl)-me...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163616((2-Chloro-3-ethyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598907(CHEMBL5178023)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598912(CHEMBL5170313)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163606(1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-ph...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163609((4-Methoxy-cyclohexyl)-(2-methyl-3-propyl-quinolin...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598906(CHEMBL5181951)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163601((2,3-Dihydro-benzo[1,4]dioxin-2-yl)-(3-ethyl-2-met...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163609((4-Methoxy-cyclohexyl)-(2-methyl-3-propyl-quinolin...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163611(1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-th...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163590((2,3-Diethyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163615((4-Methoxy-cyclohexyl)-(1-methyl-1,2,3,4-tetrahydr...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163623((3-Ethyl-2-fluoro-quinolin-6-yl)-(4-methoxy-cycloh...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50:  10nMAssay Description:Inhibition of mouse DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598924(CHEMBL5201357)
Affinity DataIC50:  10nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163604(1-(3-Ethyl-2-methyl-quinolin-6-yl)-2-phenyl-ethano...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598925(CHEMBL5197655)
Affinity DataIC50:  11nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163584((3-Ethyl-2-iodo-quinolin-6-yl)-(4-methoxy-cyclohex...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163599(Bicyclo[2.2.1]hept-2-yl-(3-ethyl-2-methyl-quinolin...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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