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Found 252 with Last Name = 'smenton' and Initial = 'a'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221971((2S,3S)-3-(4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)c...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221979((2S,3S)-2-((1r,4S)-4-([1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221968((2S,3S)-2-((1r,4S)-4-([1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319102(5-(3,5-difluorophenyl)-2-(3-(6-hydroxynaphthalen-2...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221972((2S,3S)-2-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)p...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319109(2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50313977(2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221984((2S,3S)-2-amino-1-(3,3-difluoropyrrolidin-1-yl)-3-...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221970((2S,3S)-2-((1r,4S)-4-([1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319096(5-butyl-2-(3-(6-hydroxynaphthalen-2-yl)propanamido...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319123((4S,5R)-2-(3-(3-(5-fluoropyridin-2-yl)-1,2,4-oxadi...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319110(5-(3-fluorophenyl)-2-(3-(3-(5-hydroxypyridin-2-yl)...)
Affinity DataIC50:  7nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319100(5-(3-fluorophenyl)-2-(3-(6-hydroxynaphthalen-2-yl)...)
Affinity DataIC50:  7.40nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319095(2-(3-(6-hydroxynaphthalen-2-yl)propanamido)-5-prop...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50271314(2-(3-(6-hydroxynaphthalen-2-yl)propanamido)cyclohe...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319113((4S,5R)-5-(3-fluorophenyl)-2-(3-(3-(5-hydroxypyrid...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319101(5-(4-fluorophenyl)-2-(3-(6-hydroxynaphthalen-2-yl)...)
Affinity DataIC50:  8.60nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319111(5-(6-fluoropyridin-3-yl)-2-(3-(3-(5-hydroxypyridin...)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319120(2-(3-(3-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221978((2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-2-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319099(5-(2-fluorophenyl)-2-(3-(6-hydroxynaphthalen-2-yl)...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221966((2S,3S)-2-amino-1-((S)-3-fluoro-3-methylpyrrolidin...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319112((4S,5R)-2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxad...)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221967((2S,3S)-3-amino-2-(4'-fluoro-biphenyl-4-yl)-4-((S)...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319106(2-(3-(6-hydroxynaphthalen-2-yl)propanamido)-5-(1-m...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319121(2-(2-amino-3-(3-(5-fluoropyridin-2-yl)-1,2,4-oxadi...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319104(5-(6-fluoropyridin-3-yl)-2-(3-(6-hydroxynaphthalen...)
Affinity DataIC50:  16nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221982(CHEMBL237547 | N-((1S,4r)-4-((2S,3S)-3-amino-4-((S...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319105(2-(3-(6-hydroxynaphthalen-2-yl)propanamido)-5-(6-(...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319118(5-(3,5-difluorophenyl)-2-(3-(3-(5-fluoropyridin-2-...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50323394(5-(2,3,5-trifluorophenyl)-1,4,5,6-tetrahydrocyclop...)
Affinity DataIC50:  20nMAssay Description:Displacement of [3H]nicotinic acid from human GPR10a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221968((2S,3S)-2-((1r,4S)-4-([1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human DPP4 in presence of 50 % human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221979((2S,3S)-2-((1r,4S)-4-([1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human DPP4 in presence of 50 % human serumMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319119(2-(2-amino-3-(3-(5-fluoropyridin-2-yl)-1,2,4-oxadi...)
Affinity DataIC50:  28nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221971((2S,3S)-3-(4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)c...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human DPP4 in presence of 50 % human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323394(5-(2,3,5-trifluorophenyl)-1,4,5,6-tetrahydrocyclop...)
Affinity DataIC50:  30nMAssay Description:Displacement of [3H]nicotinic acid from mouse GPR10a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221981((2S,3S)-2-((1s,4R)-4-([1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319115(2-(2-amino-3-(3-(5-fluoropyridin-2-yl)-1,2,4-oxadi...)
Affinity DataIC50:  32nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319097(2-(3-(6-hydroxynaphthalen-2-yl)propanamido)-5-phen...)
Affinity DataIC50:  34nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319114(2-(3-(3-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  35nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319108(5-(2-fluoropyridin-3-yl)-2-(3-(4'-hydroxybiphenyl-...)
Affinity DataIC50:  36nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221969((2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319094(2-(3-(6-hydroxynaphthalen-2-yl)propanamido)-5-meth...)
Affinity DataIC50:  43nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319103(5-(2-fluoropyridin-3-yl)-2-(3-(6-hydroxynaphthalen...)
Affinity DataIC50:  52nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50319116(5-(3-fluorophenyl)-2-(3-(3-(5-fluoropyridin-2-yl)-...)
Affinity DataIC50:  57nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221977((2S,3S)-2-amino-3-(4'-fluoro-biphenyl-4-yl)-1-((S)...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50298000((+/-)-5-(2,3,5-trifluorophenyl)-4,5,6,7-tetrahydro...)
Affinity DataIC50:  67nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277789(3-(1H-tetrazol-5-yl)-5-(2,3,5-trifluorophenyl)-1,4...)
Affinity DataIC50:  70nMAssay Description:Displacement of [3H]nicotinic acid from mouse GPR10a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277790(5-(3,5-difluorophenyl)-3-(1H-tetrazol-5-yl)-1,4,5,...)
Affinity DataIC50:  70nMAssay Description:Displacement of [3H]nicotinic acid from mouse GPR109a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277789(3-(1H-tetrazol-5-yl)-5-(2,3,5-trifluorophenyl)-1,4...)
Affinity DataIC50:  70nMAssay Description:Displacement of [3H]nicotinic acid from mouse GPR109a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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