Affinity DataKi: <0.0100nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0100nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0200nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0300nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0300nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0400nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0500nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.280nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.380nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.990nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Binding affinity to BCL-W (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 55nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 80nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 88nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 90nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 90nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 140nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 220nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 240nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 280nMAssay Description:Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 320nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataKi: >440nMAssay Description:Binding affinity to MCL1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 1.10nMpH: 7.4 T: 2°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 1.5nMpH: 7.4 T: 2°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assayMore data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair