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Found 215 with Last Name = 'spek' and Initial = 'al'
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50020178(CHEMBL294633 | CHEMBL555633 | N-[2-(4-Benzofuran-7...)
Affinity DataKi:  0.150nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50039824(CHEMBL81728 | N-{2-[4-(2,3-Dihydro-benzo[1,4]dioxi...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056040(CHEMBL107141 | Cyclohexanecarbothioic acid {2-[4-(...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50150945(CHEBI:81390 | Immepip)
Affinity DataKi:  0.479nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056034(CHEMBL108229 | Cyclohexanecarboxylic acid {2-[4-(2...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50019959(1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...)
Affinity DataKi:  1nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056029(CHEMBL316960 | N-{2-[4-(2,3-Dihydro-benzo[1,4]diox...)
Affinity DataKi:  1nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50019960(4-Fluoro-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl...)
Affinity DataKi:  1nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Rattus norvegicus)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for rat adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056026(1-[4-(4-Fluoro-phenyl)-butyl]-4-(2-methoxy-phenyl)...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125I]AB-MECA from membranes of HEK 293 cells expressing human Adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056024(CHEMBL106854 | N-{2-[4-(2-Methoxy-phenyl)-piperazi...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50474424(CHEMBL153051)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056027(CHEMBL419910 | Thiophene-2-carboxylic acid {2-[4-(...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50454759(Flesinoxan)
Affinity DataKi:  1.70nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056023(1-[(E)-4-(4-Fluoro-phenyl)-but-3-enyl]-4-(2-methox...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056039(1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50019959(1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...)
Affinity DataKi:  3.10nMAssay Description:In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056038(1-[3-(4-Fluoro-phenoxy)-propyl]-4-(2-methoxy-pheny...)
Affinity DataKi:  3.30nMAssay Description:In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056026(1-[4-(4-Fluoro-phenyl)-butyl]-4-(2-methoxy-phenyl)...)
Affinity DataKi:  3.30nMAssay Description:In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056038(1-[3-(4-Fluoro-phenoxy)-propyl]-4-(2-methoxy-pheny...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056039(1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...)
Affinity DataKi:  3.40nMAssay Description:In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50474427(CHEMBL153061)
Affinity DataKi:  3.60nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity for human adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50474428(CHEMBL152936)
Affinity DataKi:  4nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056023(1-[(E)-4-(4-Fluoro-phenyl)-but-3-enyl]-4-(2-methox...)
Affinity DataKi:  4.10nMAssay Description:In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50170164(Imbutamine)
Affinity DataKi:  4.10nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50215536((R)-Alpha-Methylhistamine | CHEBI:73337 | CHEMBL26...)
Affinity DataKi:  4.40nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50409817(CHEMBL78498 | VUF-5681)
Affinity DataKi:  4.5nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056025(CHEMBL107903 | N-{2-[4-(2-Methoxy-phenyl)-piperazi...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056037(4-Fluoro-N-[2-(4-phenyl-piperazin-1-yl)-ethyl]-ben...)
Affinity DataKi:  4.90nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50019960(4-Fluoro-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl...)
Affinity DataKi:  5nMAssay Description:In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50474426(Impentamine)
Affinity DataKi:  5.10nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50474433(CHEMBL440730)
Affinity DataKi:  5.20nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50020178(CHEMBL294633 | CHEMBL555633 | N-[2-(4-Benzofuran-7...)
Affinity DataKi:  5.30nMAssay Description:In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM25400((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]DPCPX (without GTP) from Adenosine A1 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50474425(CHEMBL356666)
Affinity DataKi:  5.90nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056040(CHEMBL107141 | Cyclohexanecarbothioic acid {2-[4-(...)
Affinity DataKi:  6.40nMAssay Description:In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50121205(CHEBI:18295 | Histamine)
Affinity DataKi:  9.30nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50127605((1S,2S)-2-(1H-Imidazol-4-yl)-cyclopropylamine | (1...)
Affinity DataKi:  9.30nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50407522(CHEMBL554031)
Affinity DataKi:  10nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056030(1-[2-(4-Fluoro-benzyloxy)-ethyl]-4-(2-methoxy-phen...)
Affinity DataKi:  10nMAssay Description:In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  11nMAssay Description:Ability to displace radioligand [125I]AB-MECA from membrane of HEK 293 cells stably transfected with human adenosine A3 receptor cDNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50056024(CHEMBL106854 | N-{2-[4-(2-Methoxy-phenyl)-piperazi...)
Affinity DataKi:  13nMAssay Description:In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50035042(1-Benzofuran-7-yl-piperazine | CHEMBL61032)
Affinity DataKi:  13nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  14nMAssay Description:Binding affinity for human adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50039824(CHEMBL81728 | N-{2-[4-(2,3-Dihydro-benzo[1,4]dioxi...)
Affinity DataKi:  14nMAssay Description:In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50121205(CHEBI:18295 | Histamine)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50170164(Imbutamine)
Affinity DataKi:  14.5nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Leiden University

Curated by ChEMBL
LigandPNGBDBM35804((CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmet...)
Affinity DataKi:  15nMAssay Description:Ability to displace radioligand [3H]- CGS 21680 from adenosine A2A receptor on rat striatal membraneMore data for this Ligand-Target Pair
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