Compile Data Set for Download or QSAR
maximum 50k data
Found 19 with Last Name = 'spiegel' and Initial = 'k'
TargetTumor necrosis factor receptor superfamily member 16(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50029495(7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo...)
Affinity DataIC50:  200nMAssay Description:Inhibition of [125I]- NGF binding to extracellular domain of p75 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 16(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50029497(2-Methyl-7-oxo-5-(tetrazol-1-ylcarbamoyl)-4,7-dihy...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of [125I]- NGF binding to extracellular domain of p75 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 16(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50029494(2-Methyl-7-oxo-4,7-dihydro-thieno[3,2-b]pyridine-3...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of [125I]- NGF binding to extracellular domain of p75 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 16(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50029496(6-Amino-4-oxo-1,4-dihydro-quinoline-2-carboxylic a...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of [125I]- NGF binding to extracellular domain of p75 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297400(US10117858, Example 4 | US10117858, Example 6 | US...)
Affinity DataEC50:  76nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297410(US10117858, Example 17)
Affinity DataEC50:  10nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  50nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297403(3-Amino-6-methoxy-5-trifluoromethyl-pyridine-2-car...)
Affinity DataEC50:  35nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297400(US10117858, Example 4 | US10117858, Example 6 | US...)
Affinity DataEC50:  426nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297405(5-Amino-6′-methyl-3-trifluoromethyl-[2,3R...)
Affinity DataEC50:  115nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297406(3-Amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyri...)
Affinity DataEC50:  40nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297407(5-Amino-6′-methyl-3-trifluoromethyl-[2,3R...)
Affinity DataEC50:  51nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297408(3-Amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyri...)
Affinity DataEC50:  60nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297409(US10117858, Example 16 | US20240058315, Example 17)
Affinity DataEC50:  8nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297397(US10117858, Example 10 | US10117858, Example 9 | U...)
Affinity DataEC50:  112nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297398(3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carbo...)
Affinity DataEC50:  55nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297397(US10117858, Example 10 | US10117858, Example 9 | U...)
Affinity DataEC50:  90nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297396(3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carbo...)
Affinity DataEC50:  15nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297401(3-Amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyri...)
Affinity DataEC50:  37nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent