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Found 144 with Last Name = 'sprague' and Initial = 'e'
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235402(CHEMBL4077934)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of MELK (unknown origin) containing kinase domain and UBA domain using STK S1 as substrate after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50185443(CHEMBL3824328)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469565(CHEMBL4082918)
Affinity DataIC50:  1nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50185439(CHEMBL3823975)
Affinity DataIC50:  1nMAssay Description:Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235407(CHEMBL4088246)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MELK (unknown origin) containing kinase domain and UBA domain using STK S1 as substrate after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469558(CHEMBL4061041)
Affinity DataIC50:  1.46nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235401(CHEMBL4071823)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of MELK (unknown origin) containing kinase domain and UBA domain using STK S1 as substrate after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235399(CHEMBL4092605)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of MELK (unknown origin) containing kinase domain and UBA domain using STK S1 as substrate after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50185433(CHEMBL3824068)
Affinity DataIC50:  2nMAssay Description:Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...More data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50185433(CHEMBL3824068)
Affinity DataIC50:  2nMAssay Description:Binding affinity to MELK (unknown origin) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50249583(CHEMBL4097399)
Affinity DataIC50:  3.13nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469562(CHEMBL4069725)
Affinity DataIC50:  3.56nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50185436(CHEMBL3823874)
Affinity DataIC50:  4nMAssay Description:Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469559(CHEMBL4063087)
Affinity DataIC50:  4.15nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469555(CHEMBL4090716)
Affinity DataIC50:  4.19nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50:  5nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50185433(CHEMBL3824068)
Affinity DataIC50:  5nMAssay Description:Inhibition of full-length MELK (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence of 2...More data for this Ligand-Target Pair
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50185434(CHEMBL3823302)
Affinity DataIC50:  6nMAssay Description:Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50185437(CHEMBL3822465)
Affinity DataIC50:  6nMAssay Description:Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50365218(CHEMBL1956071 | GSK screening, 29)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N1(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)
Affinity DataIC50:  7nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235404(CHEMBL4085799)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of MELK (unknown origin) containing kinase domain and UBA domain using STK S1 as substrate after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50185435(CHEMBL3823918)
Affinity DataIC50:  9nMAssay Description:Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...More data for this Ligand-Target Pair
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235406(CHEMBL4066968)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of MELK (unknown origin) containing kinase domain and UBA domain using STK S1 as substrate after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235405(CHEMBL4095977)
Affinity DataIC50:  12nMAssay Description:Inhibition of MELK (unknown origin) containing kinase domain and UBA domain using STK S1 as substrate after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50:  12nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469560(CHEMBL4083624)
Affinity DataIC50:  12.5nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50185444(CHEMBL3822876)
Affinity DataIC50:  13nMAssay Description:Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028036(CHEMBL3338840)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50365218(CHEMBL1956071 | GSK screening, 29)
Affinity DataIC50:  14nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469563(CHEMBL4079368)
Affinity DataIC50:  16.4nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50469550(CHEMBL4070478)
Affinity DataIC50:  19.7nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028030(CHEMBL3338842)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)
Affinity DataIC50:  21nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028034(CHEMBL3338838)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50185438(CHEMBL3824157)
Affinity DataIC50:  25nMAssay Description:Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028034(CHEMBL3338838)
Affinity DataIC50:  32nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase N1(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)
Affinity DataIC50:  35nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50185445(CHEMBL3824074)
Affinity DataIC50:  36nMAssay Description:Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50:  36nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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