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Found 39 with Last Name = 'sridhar' and Initial = 'r'
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University

LigandPNGBDBM13925((3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl ...)
Affinity DataKi:  0.00450nM ΔG°:  -64.8kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University

LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.0140nM ΔG°:  -62.0kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University

LigandPNGBDBM13924((3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl ...)
Affinity DataKi:  0.140nM ΔG°:  -56.2kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50241083(6-(4-chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1...)
Affinity DataKi:  0.340nMAssay Description:Antagonist activity at rat MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50094880(CHEMBL3589145)
Affinity DataKi:  0.800nMAssay Description:Antagonist activity at rat MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50094885(CHEMBL3588863)
Affinity DataKi:  3.80nMAssay Description:Antagonist activity at rat MCHR1 assessed as 2-(4-chlorophenyl)-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University

LigandPNGBDBM13926((2R,3aR,6aS)-octahydropentalen-2-yl N-[(2S,3R)-3-h...)
Affinity DataKi:  5.30nM ΔG°:  -47.2kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50094881(CHEMBL3589155)
Affinity DataKi:  7.20nMAssay Description:Antagonist activity at rat MCHR1 assessed as 6-(4-chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-oneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50094884(CHEMBL3589154)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as inhibition of MCH-stimulated Ca2+ influx preincubated for 120 mins followed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50241083(6-(4-chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as inhibition of MCH-stimulated Ca2+ influx preincubated for 120 mins followed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50094880(CHEMBL3589145)
Affinity DataIC50:  241nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as inhibition of MCH-stimulated Ca2+ influx preincubated for 120 mins followed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50094882(CHEMBL3589135)
Affinity DataIC50:  1.17E+3nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as inhibition of MCH-stimulated Ca2+ influx preincubated for 120 mins followed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM22372(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50006811(2-(12-Hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-p...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen elec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50094883(CHEMBL3589138)
Affinity DataIC50:  3.06E+3nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as inhibition of MCH-stimulated Ca2+ influx preincubated for 120 mins followed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50324109(3,4,5-Trimethoxy-2',4'-di-O-prenylchalcone | CHEMB...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50359871(CHEMBL1929096)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen elec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50324108(3,4-Dimethoxy-2',4'-di-O-prenylchalcone | CHEMBL12...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50359870(CHEMBL1929095)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen elec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50324106(2,3-Dimethoxy-2',4'-di-O-prenylchalcone | CHEMBL12...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50094879(CHEMBL3589153)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated whole-cell patch clamp electrophysiology systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50359868(CHEMBL1929093)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen elec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50324107(2,3,4-Trimethoxy-2',4'-di-O-prenylchalcone | CHEMB...)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50359869(CHEMBL1929094)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen elec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50359864(CHEMBL1929089)
Affinity DataIC50:  6.90E+4nMAssay Description:Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen elec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50359865(CHEMBL1929090)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen elec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50094878(CHEMBL3589152)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated whole-cell patch clamp electrophysiology systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50359867(CHEMBL1929092)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen elec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50359866(CHEMBL1929091)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen elec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50359863(CHEMBL1929088)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen elec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50359862(CHEMBL1929087)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen elec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50359861(CHEMBL1929086)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen elec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM29149(substituted chalcone, 5c)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50324105(4-Methoxy-2',4'-di-O-prenylchalcone | CHEMBL121504...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50324104(2'-Hydroxy-3,4,5-trimethoxy-4'-O-prenylchalcone | ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50324101(2'-Hydroxy-2,3-dimethoxy-4'-O-prenylchalcone | CHE...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50324102(2'-Hydroxy-2,3,4-trimethoxy-4'-O-prenylchalcone | ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50324103(2'-Hydroxy-3,4-dimethoxy-4'-O-prenylchalcone | CHE...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Hyderabad

Curated by ChEMBL
LigandPNGBDBM50359860(CHEMBL1929097)
Affinity DataIC50:  7.60E+5nMAssay Description:Inhibition of 5-LOXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed