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Found 477 with Last Name = 'stallings' and Initial = 'wc'
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297794(2-(4-(cyclohexylmethyl)-6-(6-methoxypyridin-3-yl)-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297796(4-(cyclohexylmethyl)-6-(2-methoxypyrimidin-5-yl)-2...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297795(4-(cyclohexylmethyl)-6-(6-methoxypyridin-3-yl)-2-(...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296257(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297797(4-(cyclohexylmethyl)-6-(6-methoxypyridin-3-yl)-2-(...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297798(4-(cyclohexylmethyl)-6-(pyridin-4-yl)-2-((tetrahyd...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296253(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297799(4-(cyclohexylmethyl)-6-(3,5-dimethylisoxazol-4-yl)...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296255(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296254(2-(6-methoxypyridin-3-yl)-6-(2-morpholinoethylamin...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297800(6-(4-fluorophenyl)-4-(4-methoxybenzyl)-2-(2-morpho...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297801(4-(cyclohexylmethyl)-6-(3,4-difluorophenyl)-2-(2-m...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167837(3-Amino-N-((R)-sec-butyl)-5-{1-[(4-carbamimidoyl-b...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297802(6-(3,4-difluorophenyl)-4-(4-methoxybenzyl)-2-(2-mo...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297803(6-(6-methoxypyridin-3-yl)-4-(2-propoxyethyl)-2-((t...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296252(6-(6-methoxypyridin-3-yl)-2-(2-morpholinoethylamin...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297804(6-(4-fluorophenyl)-4-(pyridin-3-ylmethyl)-2-((tetr...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297805(4-(3,5-difluorobenzyl)-6-(4-fluorophenyl)-2-((tetr...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296252(6-(6-methoxypyridin-3-yl)-2-(2-morpholinoethylamin...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297806(4-(cyclohexylmethyl)-6-(6-hydroxypyridin-3-yl)-2-(...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297807(4-(cyclohexylmethyl)-6-(4-fluorophenyl)-2-((tetrah...)
Affinity DataIC50:  3nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297808(2-(4-(cyclohexylmethyl)-6-(4-fluorophenyl)-3-oxo-3...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297809(4-(cyclohexylmethyl)-6-(4-fluorophenyl)-2-(2-morph...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167830(3-amino-N-[(2R)-butan-2-yl]-5-[1-({[(4-carbamimido...)
Affinity DataIC50:  6.20nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167833(3-amino-N-[(2R)-butan-2-yl]-5-(1-{[({4-carbamimido...)
Affinity DataIC50:  9.40nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19440(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  12nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167836(3-amino-N-[(2R)-butan-2-yl]-5-(1-{[({4-carbamimido...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297810(4-(cyclohexylmethyl)-6-(4-fluorophenyl)-2-(pyridin...)
Affinity DataIC50:  13nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297811(2-(6-(6-methoxypyridin-3-yl)-3-oxo-4-(2-propoxyeth...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14593(3-amino-5-[1-({[(4-carbamimidoylphenyl)methyl]carb...)
Affinity DataIC50:  16nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19439(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  16nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50:  20nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14535(2-[6-(3-aminophenyl)-5-chloro-2-oxo-3-(propan-2-yl...)
Affinity DataIC50:  20nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167835(3-amino-N-[(2R)-butan-2-yl]-5-[1-({[(4-carbamimido...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297812(6-(4-fluorophenyl)-4-(pyridin-2-ylmethyl)-2-((tetr...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167831(CHEMBL189166 | {2-[(2-{6-[3-Amino-5-((R)-sec-butyl...)
Affinity DataIC50:  21nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297813(6-(4-fluorophenyl)-4-(2-propoxyethyl)-2-((tetrahyd...)
Affinity DataIC50:  22nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167832(CHEMBL189597 | {2-[(2-{6-[3-Amino-5-((R)-sec-butyl...)
Affinity DataIC50:  23nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297793(1-(4-methoxybenzyl)-7-(pyridin-4-yl)quinolin-2(1H)...)
Affinity DataIC50:  25nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50130063((R)-N-{(S)-1-[(S)-4-Guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  27nMAssay Description:Inhibition of coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297814(6-(2-methoxypyrimidin-5-yl)-2-(2-morpholinoethylam...)
Affinity DataIC50:  27nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50130063((R)-N-{(S)-1-[(S)-4-Guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against coagulation factor X.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297815(2-amino-4-(cyclohexylmethyl)-6-(4-fluorophenyl)pyr...)
Affinity DataIC50:  29nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity of the compound against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297816(6-(4-fluorophenyl)-2-(2-morpholinoethylamino)-4-(2...)
Affinity DataIC50:  33nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297817(4-(2-propoxyethyl)-6-(pyridin-4-yl)-2-((tetrahydro...)
Affinity DataIC50:  34nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297818(6-(3,5-dimethylisoxazol-4-yl)-2-(2-morpholinoethyl...)
Affinity DataIC50:  37nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50133093((R)-N-{(S)-1-[(S)-4-guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against thrombin (IIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14520(N-[(4-carbamimidoylphenyl)methyl]-2-(5-chloro-3-{[...)
Affinity DataIC50: <40nMAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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