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Found 115 with Last Name = 'staples' and Initial = 'd'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi: <1nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to reninMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to reninMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  3nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281641((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  4nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  5nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  8nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281640(CHEMBL433729 | Pyridine-2-carboxylic acid ((1S,2S,...)
Affinity DataKi:  8nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281651((2S,4S,5S)-5-Acetylamino-6-cyclohexyl-4-hydroxy-2-...)
Affinity DataKi:  8nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  9nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281648(CHEMBL166640 | [(S)-1-((1S,2S,4S)-1-Cyclohexylmeth...)
Affinity DataKi:  10nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  12nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to pepsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281644(CHEMBL355867 | N*1*-[(1S,2S,4S)-1-Cyclohexylmethyl...)
Affinity DataKi:  14nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281643((2S,4S,5S)-5-Acetylamino-6-cyclohexyl-4-hydroxy-2-...)
Affinity DataKi:  16nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281652((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-{(...)
Affinity DataKi:  30nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGenome polyprotein(Human rhinovirus B)
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi:  30nMAssay Description:Tested for the inhibition of HIV-2 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281639((2S,4S,5S)-6-Cyclohexyl-5-hexanoylamino-4-hydroxy-...)
Affinity DataKi:  47nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  50nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281637((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-{(...)
Affinity DataKi:  61nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281646((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-(2...)
Affinity DataKi:  61nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGenome polyprotein(Human rhinovirus B)
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  65nMAssay Description:Compound was evaluated for the inhibition of HIV-2 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281645((2S,4S,5S)-6-Cyclohexyl-5-(3,3-dimethyl-butyrylami...)
Affinity DataKi:  75nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  90nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  100nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi:  142nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGenome polyprotein(Human rhinovirus B)
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  170nMAssay Description:Compound was evaluated for the inhibition of HIV-2 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  200nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  212nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to reninMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi:  265nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to pepsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  290nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to pepsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  330nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to pepsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281650((2S,4S,5S)-5-Amino-6-cyclohexyl-4-hydroxy-2-isopro...)
Affinity DataKi:  800nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281649((S)-2-((2S,4S,5S)-5-{(S)-3-Carbamoyl-2-[(quinoline...)
Affinity DataKi: >1.00E+3nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281647((2S,4S,5S)-5-Acetylamino-6-cyclohexyl-4-hydroxy-2-...)
Affinity DataKi: >1.00E+3nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  1.20E+3nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to reninMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022835(Ac-Ftr-Pro-Phe-His-Sta-Ile-NH2 | CHEMBL419531)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50368278(CHEMBL1790497)
Affinity DataIC50:  0.110nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022861(Ac-Ftr-Pro-Phe-His-Leu(psi)[CH(OH)CH2]Val-NH2 | CH...)
Affinity DataIC50:  0.310nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022846(Ac-Ftr-Pro-Phe-His-Sta-Val-Ftr-NH2 | CHEMBL275711)
Affinity DataIC50:  0.380nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022845(Ac-Ftr-Pro-Phe-His-Sta-Val-NH2 | CHEMBL318388)
Affinity DataIC50:  0.530nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022836(CGP-2928 | CHEMBL216847 | Z-Arg-Arg-Pro-Phe-His-St...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022844(Ac-Trp-Pro-Phe-His-Sta-Ile-NH2 | CHEMBL317280)
Affinity DataIC50:  1.60nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022847(Ac-Ftr-Pro-Phe-His-Sta-Ftr-NH2 | CHEMBL100924)
Affinity DataIC50:  3.80nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Rattus norvegicus)
Upjohn

Curated by ChEMBL
LigandPNGBDBM50022846(Ac-Ftr-Pro-Phe-His-Sta-Val-Ftr-NH2 | CHEMBL275711)
Affinity DataIC50:  4.90nMAssay Description:In vitro inhibitory activity towards porcine kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022841(Ac-His-Pro-Phe-His-Sta-Ile-NH2 | CHEMBL329933)
Affinity DataIC50:  6.80nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022859(CHEMBL407670 | Pro-His-Pro-Phe-His-Leu[CH2NH]Val-I...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022860(Ac-D-Ftr-Pro-Phe-His-Sta-Ile-NH2 | CHEMBL330412)
Affinity DataIC50:  14nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022837(CHEMBL437836 | Iva--His-Pro-Phe-His-Sta-Leu-Phe-NH...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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